A5101567093- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cardiomyopathy and Myosin Studies
- Infectious Aortic and Vascular Conditions
- Cardiac Valve Diseases and Treatments
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Refrigeration and Air Conditioning Technologies
- Extracellular vesicles in disease
- Connective tissue disorders research
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Ferroptosis and cancer prognosis
- Cardiovascular Disease and Adiposity
- Abdominal vascular conditions and treatments
- Heat Transfer and Optimization
- Galectins and Cancer Biology
- Diabetes and associated disorders
- Biochemical and Molecular Research
- Photosynthetic Processes and Mechanisms
- Cardiovascular Issues in Pregnancy
Guangzhou University of Chinese Medicine
2021-2025
North China Institute of Science and Technology
2025
Zhejiang Chinese Medical University
2024
Key Laboratory of Guangdong Province
2024
Guangdong Academy of Medical Sciences
2019-2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2019-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2021-2024
Guangdong General Hospital
2023
BACKGROUND: Aortic dissection (AD) is a fatal cardiovascular disorder without effective medications due to unclear pathogenic mechanisms. Bestrophin3 (Best3), the predominant isoform of bestrophin family in vessels, has emerged as critical for vascular pathological processes. However, contribution Best3 diseases remains elusive. METHODS: Smooth muscle cell–specific and endothelial knockout mice (Best3 SMKO ECKO , respectively) were engineered investigate role pathophysiology. Functional...
Aims: Abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) are considered early events in the onset thoracic aortic dissection (TAD). Endogenous sulfur dioxide (SO2), primarily produced by aspartate aminotransferase (AAT1) mammals, has been reported to inhibit VSMCs. However, role SO2 development TAD remains unclear. Results: production was decreased samples from patients with TAD. Supplementation ameliorated β-aminopropionitrile-induced injury mice. Increasing...
Rationale: Hyperglycemia-induced endothelial dysfunction is a hallmark of diabetic cardiomyopathy, yet the underlying molecular mechanisms remain incompletely understood. This study aimed to investigate how DNA damage response (DDR) pathway regulates cell ferroptosis under hyperglycemic conditions, potentially revealing new therapeutic targets for mitigating cardiac in type 2 diabetes mellitus (T2DM). Methods: We performed an integrated analysis publicly available RNA sequencing datasets...
Background This study aimed to investigate whether miR‐146a‐5p was involved in the pathogenesis of thoracic aortic dissection (AD) via regulating biological function vascular smooth muscle cells (VSMCs). Methods Circulating level measured by quantitative polymerase chain reaction (qPCR) AD patients and healthy controls. Human dissected samples were obtained from with Stanford type A undergoing surgical repair, normal control organ donors who died nonvascular diseases. The expression detected...
Abstract Background The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival cytoplasmic environment stability, but disorganized mechanics with respect developing heart failure (HF) is currently unknown. Methods We conducted a multi-omics wide analysis, including microarray-based transcriptomes, full spectrum metabolomics chronic HF. Based on expression profiling by array, we applied bioinformatics platform quantifiable...
Abstract Aims The precise molecular drivers of abdominal aortic aneurysm (AAA) remain unclear. Thymidine phosphorylase (TYMP) contributes to increased platelet activation, thrombosis, and inflammation, all which are key factors in AAA development. Additionally, TYMP suppresses the proliferation vascular smooth muscle cells (VSMCs), central development progression AAA. We hypothesize that plays a role Methods Results conducted histological study using human samples normal aortas, revealing...
Abstract Aim The current study aimed to examine miR‐145's contribution thoracic aortic dissection (AD) development by modulating the biological functions of vascular smooth muscle cells (VSMCs). Methods concentration circulating miR‐145 was determined in patients with AD and healthy controls using quantitative polymerase chain reaction (qPCR). Aortic specimens were obtained from both individuals Stanford type A undergoing surgical treatment deceased organ donors (serving as controls) whose...
Abstract Objectives Autoimmune diseases (ADs) play a significant and intricate role in the onset of cardiovascular (CVDs). Our study aimed to elucidate shared genetic etiology between Ads CVDs. Methods We conducted genome-wide pleiotropy analyses investigate foundation comprehensively six ADs analyze architecture overlap these traits. Then, SNP-level functional annotation identified genomic risk loci potential causal variants. Gene-level explored pleiotropic genes, followed by pathway...
Deep hypothermic circulatory arrest (HCA), which causes perioperative complications, is the foundation of surgical treatment for acute type A aortic dissection (AAAD). To extensively replace dissected aorta and avoid negative impacts HCA, we developed an "aorta-clamp" technique examined its efficacy in repairing AAAD.From November 2014 to August 2016, recruited 59 consecutive patients (51.3±10.9 years) with AAAD into this study. We performed total arch replacement combined elephant trunk...
Epicardial adipose tissue (EAT) is a unique visceral fat reservoir that shares an immune microenvironment without distinct boundary with myocardium.Increasingly, has been studied as secondary organ, and EAT no exception in this regard.Cellular subsets of are associated disease development.In heart failure (HF) patients, however, the characteristics have rarely studied, especially those non-immune cells related to microenvironment.Herein, analysis seven samples by single-cell RNA sequencing...
Objectives The frozen elephant trunk (FET) technique has become an important tool in the treatment of acute type A aortic dissection. aim this study was to evaluate effect long FET on spinal cord injury (SCI) and distal remodeling after dissection based clinical radiological outcomes. Methods From January 2018 November 2019, 158 patients (mean age 51.8 years [range: 32–78 years], 88.6% male) with were treated by 100 mm (n = 113) or 150 45) open hybrid stent graft prosthesis. Patients divided...
Background: Progressive dilatation is responsible for significant mortality and morbidity in patients with thoracic aortic aneurysms (TAAs). Studies have shown that the development progression of TAAs are closely related to immune regulatory pathways genes. Therefore, it important understand mechanisms biomarkers TAA dilatation.
We sourced genetic association data from public genome-wide study databases for populations of European ancestry. Adhering to MR principles, we identified valid instrumental variables variants. A range statistical methods were applied analysis, with the inverse variance weighted (IVW) method emerging as most reliable estimator causality in this context.
<title>Abstract</title> <bold>Objectives</bold> Autoimmune diseases (ADs) play a significant and intricate role in the onset of cardiovascular (CVDs). Our study aimed to elucidate shared genetic etiology between Ads CVDs. <bold>Methods</bold> We conducted genome-wide pleiotropy analyses investigate foundation comprehensively six ADs analyze architecture overlap these traits. Then, SNP-level functional annotation identified genomic risk loci potential causal variants. Gene-level explored...
This study aimed to evaluate the therapeutic effect of QingreHuoxue formula on mice with Idiopathic Membranous Nephropathy (IMN) and its impact Th17 cells Tregs.
Endotoxemia, caused by lipopolysaccharides, triggers systemic inflammation and myocardial injury disrupting mitochondrial homeostasis. This study examines the roles of dual specificity phosphatase 1 (Dusp1) phosphoglycerate mutase family member (Pgam1) in this process.