A5071375023- Ubiquitin and proteasome pathways
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Chromosomal and Genetic Variations
- Telomeres, Telomerase, and Senescence
- CRISPR and Genetic Engineering
- Microfluidic and Capillary Electrophoresis Applications
- Epigenetics and DNA Methylation
- Radical Photochemical Reactions
- RNA and protein synthesis mechanisms
- Advanced Nanomaterials in Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Genetics and Neurodevelopmental Disorders
- Analytical chemistry methods development
- Cancer-related Molecular Pathways
- Analytical Chemistry and Chromatography
- Ionic liquids properties and applications
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- Nanocluster Synthesis and Applications
- Thyroid Cancer Diagnosis and Treatment
- Synthesis and Biological Activity
- Synthesis and Catalytic Reactions
- Aerosol Filtration and Electrostatic Precipitation
Hangzhou Normal University
2020-2024
Tobacco Research Institute
2013-2024
Zhengzhou University
2022-2024
Xinxiang Medical University
2024
Nankai University
2023
China Tobacco
2021
Chongqing University
2011
Telomerase plays a pivotal role in tumorigenesis by both telomere‐dependent and telomere‐independent activities, although the underlying mechanisms are not completely understood. Using single‐sample gene set enrichment analysis (ssGSEA) across 9,264 tumour samples, we observe that expression of telomerase reverse transcriptase (TERT) is closely associated with immunosuppressive signatures. We demonstrate TERT can activate subclass endogenous retroviruses (ERVs) independent its activity to...
Knowledge of the role CYP2E1 in hepatocarcinogenesis is largely based on epidemiological and animal studies, with a primary focus metabolic activation procarcinogens. Few studies have directly assessed effects HCC malignant phenotypes.The expression tissues was determined by qRT-PCR, western blotting immunohistochemistry. Overexpression cell achieved lentivirus transfection. The function were detected CCK-8, wound healing, transwell assays, xenograft models pulmonary metastasis model....
Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve genomic stability. However, molecular mechanisms underlying telomere attrition-induced genome instability remain to be understood. We systematically analyzed expression retrotransposons performed sequencing different cell tissue types with telomeres varying lengths due telomerase deficiency. found that critically short altered retrotransposon activity promote in mouse embryonic stem cells, as evidenced by...
A superhydrophobic coating applied in corrosion protection was successfully fabricated on the surface of aluminum alloy by chemical etching and modification. The water contact angle measured to be 161.2° ± 1.7° with sliding smaller than 8°, showed a long service life. structure composition were then characterized means SEM XPS. electrochemical measurements that significantly improved resistance alloy. phenomenon prepared analyzed Cassie theory, it found only about 6% is metal substrate 94%...
Ubiquitin-fold modifier 1 (UFM1) is a recently identified ubiquitin-like posttranslational modification with important biological functions. However, the regulatory mechanisms governing UFM1 of target proteins (UFMylation) and cellular processes controlled by UFMylation remain largely unknown. It has been previously shown that UFM1-specific protease (UFSP2) mediates maturation precursor drives de-UFMylation reaction. Furthermore, it long thought UFSP1, an ortholog UFSP2, inactive in many...
To accurately diagnose and evaluate the degree of myocardial injury predict infarction disease, rapid sensitive detection cardiac troponin I (cTnI) is required. Therefore, a label-less electrochemical aptasensor was prepared for cTnI determination. Ionic liquid 1-hydroxyethy l-3- methyl imidazole four fluorine boric acid salt (IL)-reduced graphene oxide − ethylene oxidation reduction five amine (rGO-TEPA)/silica (SiO2)- gold platinum (AuPt) (IL-rGO-TEPA/SiO2-AuPt) nanocomposites were...
Abstract A series of silicon‐containing derivatives linear alicyclic musks comprising sila‐Rosamusk ( 3b ), sila‐Romandolide 5b sila‐Applelide 11b and the corresponding dehydro was synthesized from sila‐analogs Artemone Herbac, respectively, by means sodium borohydride reduction subsequent esterification with acid chlorides in presence triethylamine. The olfactory properties new sila‐odorants – 13b are reported comparison their carba‐analogs 3a 13a , quantitative threshold data allowed...
The UFMylation modification is a novel ubiquitin-like conjugation system, consisting of UBA5 (E1), UFC1 (E2), UFL1 (E3), and the conjugating molecule UFM1. Deficiency in this leads to embryonic lethality mice diseases humans. However, function poorly characterized. Studies on Ufl1 conditional knockout have demonstrated that deletion cardiomyocytes intestinal epithelial cells causes heart failure increases susceptibility experimentally induced colitis, respectively, suggesting an essential...
Telomerase plays a pivotal role in tumorigenesis by maintaining telomere homeostasis, hallmark of cancer. However, the mechanisms which telomerase is reactivated or upregulated during remain incompletely understood. Here, we report that Hippo pathway effector Yes-associated protein (YAP) regulates expression human reverse transcriptase (hTERT). Ectopic physiological activation YAP increases hTERT expression, whereas knockdown decreases hTERT. binds to promoter through interaction with TEA...
The excessive flavorings in food are a growing public health concern, particularly foods for infants and children. A rapid simple method simultaneous detection of multiple is urgently needed. In this work, with direct analysis real time-mass spectrometry has been developed applied to the determination four flavorings, including maltol, ethyl vanillin, vanillin. ionization efficiency flavor compounds quantitatively-dip-it probe mode was compared that quick strip mode, which revealed...
Dehydration of alcohols is one the most fundamental transformations in organic chemistry class and widely used methods for producing alkenes synthetic research. Numerous reagents have been developed to control regio- stereoselectivity as well dehydration efficiency normal alcohols. Despite these achievements, stereoselective predictable allylic alcohol has seldom reported, except limited substrates with a native preferred elimination position, result challenges that many potential dienes...
Abstract Inspired by the fog collection structure on back of desert beetle, hydrophobic photonic crystal microchip (HPCM) with dual functions enrichment and surface‐enhanced Raman spectroscopy (SERS) activity is fabricated depositing thin Ag film crystals (PC) surface, this first time that wettability SERS are controlled simultaneously adjusting surface roughness. A 5 nm silver deposited PC hydrophilic SiO 2 to increase roughness so transformed from hydrophilicity hydrophobicity. The not...
Sensitive detection of monoamine oxidase B (MAO-B) is crucial to the clinical diagnosis neurodegenerative diseases. Here, a dual-mode strategy for MAO-B with dark-field light scattering imaging and colorimetry was designed based on localized surface plasmon resonance induced by silver deposited gold nanostars.
Matrix deposition plays an important role in obtaining high-quality and reliable molecular spatial location information for matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). To control the matrix film formation, automatic spraying apparatus was developed with introduction of a noncontact heating lamp. Compared unheated condition, lamp suppressed coffee-ring effect diffusion phenomenon analyte effectively by controllable formation. Meanwhile, signal intensity...