A5066714076- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Pelvic and Acetabular Injuries
- Neuroendocrine Tumor Research Advances
- Uterine Myomas and Treatments
- Bioinformatics and Genomic Networks
- Neuroblastoma Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Enhanced Recovery After Surgery
- Respiratory viral infections research
- Urinary and Genital Oncology Studies
- Cutaneous lymphoproliferative disorders research
- Influenza Virus Research Studies
- Lung Cancer Research Studies
- Computational Drug Discovery Methods
- Gestational Trophoblastic Disease Studies
- Cytomegalovirus and herpesvirus research
- Muscle Physiology and Disorders
- Urban, Neighborhood, and Segregation Studies
- Pancreatic function and diabetes
- Reproductive Health and Contraception
- Pharmacology and Obesity Treatment
- Veterinary Equine Medical Research
- Gallbladder and Bile Duct Disorders
- Reproductive Health and Technologies
The Metabolomics Innovation Centre
2023-2024
University of Alberta
2023-2024
Oregon Health & Science University
2022-2024
Harvard University Press
2024
Hospital for Sick Children
2023
Research Network (United States)
2022
University of British Columbia
2022
Canada's Michael Smith Genome Sciences Centre
2022
Twitter (United States)
2022
The University of Texas Health Science Center at Houston
2020
Abstract The commonly mutated genes in pancreatic neuroendocrine tumors (PanNETs) are ATRX , DAXX and MEN1 . We genotyped 64 PanNETs found 58% carry mutations (A-D-M mutant PanNETs) this correlates with a worse clinical outcome than carrying the wild-type alleles of all three WT PanNETs). performed RNA sequencing DNA-methylation analysis to reveal two distinct subgroups one consisting entirely A-D-M PanNETs. Two differentiating from were high ARX low PDX1 gene expression promoter...
The accurate prediction of tandem mass spectra from molecular structures has the potential to unlock new metabolomic discoveries by augmenting community's libraries experimental reference standards. Cheminformatic spectrum strategies use a "bond-breaking" framework iteratively simulate fragmentations, but these methods are (a) slow due need exhaustively and combinatorially break molecules (b) inaccurate as they often rely upon heuristics predict intensity each resulting fragment; neural...
We assessed the usefulness of real-time molecular profiling through next-generation sequencing (NGS) in predicting tumor biology advanced pancreatic neuroendocrine tumors (panNETs) and characterizing genomic evolution.Patients with metastatic panNETs were recruited routine clinical practice setting (between May 2014 March 2017) for prospective NGS their as well germline analysis using Memorial Sloan Kettering-Integrated Mutation Profiling Actionable Cancer Targets (MSK-IMPACT) platform. When...
Abstract R-loops are three-stranded nucleic acid structures formed from the hybridization of RNA and DNA. In 2012, Ginno et al. introduced first R-loop mapping method. Since that time, dozens studies have been conducted, yielding hundreds publicly available datasets. Current databases provide only limited access to these data. Moreover, no web tools for analyzing user-supplied datasets yet described. our recent work, we reprocessed 810 samples, building largest data resource date. We also...
The objective of this study was to investigate the effect essential oil (EO) supplementation on insulin sensitivity (IS) and plasma metabolome in dysregulated (ID) horses. Horses were blocked by degree IS assigned randomly treatment: oral daily bolus (50 mL) either a plant derived EO supplement or carrier (CON). Mares housed dry lots with
Ipilimumab is a monoclonal antibody that works by blocking the receptor cytotoxic T-lymphocyte–associated antigen-4 to increase T-cell activation and proliferation.1 Although morbilliform rash well-known dermatologic toxicity of ipilimumab, best our knowledge, there are no reports CD30+ lymphoid skin reactions from ipilimumab.1
In Brief This article details the different areas of structural and surgical anatomy pelvis, including abdominal wall, bony pelvis ligaments, pelvic vasculature nerves, lower urinary tract, gastrointestinal various potential spaces between viscera parietal structures.
The accurate prediction of tandem mass spectra from molecular structures has the potential to unlock new metabolomic discoveries by augmenting community's libraries experimental reference standards. Cheminformatic spectrum strategies use a "bond-breaking" framework iteratively simulate fragmentations, but these methods are (a) slow, due need exhaustively and combinatorially break molecules (b) inaccurate, as they often rely upon heuristics predict intensity each resulting fragment; neural...
OBJECTIVES.: To determine the prevalence of cervical dysplasia, diagnosed cytologically (squamous intraepithelial lesion [SIL]) or histologically (cervical neoplasia [CIN]), in women with external anogenital warts, and to discriminating risk factors between those without dysplasia. MATERIALS AND METHODS.: Chart review referred colposcopy for warts from 1990 1999. Human papillomavirus predictive dysplasia were assessed by logistic Cox regression models. RESULTS.: There 496 patients this...
Journal of Pelvic Medicine and Surgery: March 2004 - Volume 10 Issue 2 p 89 doi: 10.1097/01.spv.0000130631.53899.9d
Pelvic examinations to assess pelvic organ prolapse (POP) can vary significantly by examination method and examiner; therefore, a great deal of effort has been made standardize such examinations. Two single-center studies compared the results POP carried out intraoperatively with preoperative assessment. Data from both suggest difference between findings at time surgery under anesthesia during clinical in office. Neither study, however, reported specific impact type on intraoperative...
Background: Neonatal arterial ischemic stroke (NAIS) occurs as a result of an acute focal cerebral infarction between birth and 28 days life in nearly 1:2500 live births. As there are few studies examining the relationship NAIS lesion characteristics clinical outcomes, this study aims to determine if volume location associated with abnormal neurological outcomes NAIS. Methods: Semi-automated segmentation co-registered multi-modal images was conducted using ITK-SNAP. segmentations manual...