A5084772590- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Plant and Biological Electrophysiology Studies
- EEG and Brain-Computer Interfaces
- Advanced Fluorescence Microscopy Techniques
- Circadian rhythm and melatonin
- Morphological variations and asymmetry
- Olfactory and Sensory Function Studies
- Neuroscience and Neural Engineering
- Fuzzy Logic and Control Systems
- Light effects on plants
- Neuroscience and Music Perception
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Neural Networks and Applications
- Sleep and related disorders
- Control Systems and Identification
- Neuroendocrine regulation and behavior
Howard Hughes Medical Institute
2018-2024
Janelia Research Campus
2018-2024
California Institute of Technology
2011-2022
University of Wisconsin–Madison
2009-2011
Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of
Anchoring goals to spatial representations enables flexible navigation but is challenging in novel environments when both must be acquired simultaneously. We propose a framework for how Drosophila uses internal of head direction (HD) build goal upon selective thermal reinforcement. show that flies use stochastically generated fixations and directed saccades express heading preferences an operant visual learning paradigm HD neurons are required modify these based on used symmetric setting...
study objectives: Sleep after learning often benefits memory consolidation, but the underlying mechanisms remain unclear.In previous studies, we found that a visuomotor task is followed by an increase in sleep slow wave activity (SWA, electroencephalographic [EEG] power density between 0.5 and 4.5 Hz during non-rapid eye movement sleep) over right parietal cortex.The SWA correlates with postsleep improvement performance, suggesting may be causally responsible for consolidation of...
ABSTRACT Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron-microscopy-based connectome of Drosophila CX, including all its neurons circuits at synaptic resolution. identified new CX neuron types,...
Abstract Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to measure neural activity in intact nervous systems. GECIs are frequently one of two different modes: track large populations neuronal cell bodies, or follow dynamics subcellular compartments such as axons, dendrites and individual synaptic compartments. Despite major advances, still limited by the biophysical properties existing GECIs, including affinity, signal-to-noise ratio, rise decay...
Monitoring the membrane potential of individual neurons has uncovered how single-cell properties contribute to network processing across different brain states in neocortex. In contrast, subthreshold modulation hippocampal by state not been systematically characterized. To address this, we combined whole-cell recordings from dentate granule cells and CA1 pyramidal with multisite extracellular behavioral measurements awake mice. We show that average potential, amplitude fluctuations, distance...
Abstract Navigating animals continuously integrate velocity signals to update internal representations of their directional heading and spatial location in the environment. How neural circuits combine sensory motor information construct these estimates how self-motion signals, turn, that support navigational computations are not well understood. Recent work Drosophila has identified a circuit performs angular path integration compute fly’s head direction, but nature signal is unknown. Here...
ABSTRACT Anchoring goals to spatial representations enables flexible navigation in both animals and artificial agents. However, using this strategy can be challenging novel environments, when goal must acquired quickly simultaneously. Here, we propose a framework for how Drosophila use their internal representation of head direction build heading upon selective thermal reinforcement. We show that flies well-established operant visual learning paradigm stochastically generated fixations...
Goldstein MR, Plante DT, Hulse BK, Sarasso S, Landsness EC, Tononi G, Benca RM. Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis major depression. Objective: Sleep is depressive disorder (MDD). Pre‐ to postsleep decline (AEP) has been correlated with slow wave activity (SWA), suggesting that overnight AEP are homeostatically regulated healthy individuals. This study investigated whether the change and its relation SWA MDD. Method: Using...
Hippocampal ripples are transient population bursts that structure cortico-hippocampal communication and play a central role in memory processing. However, the mechanisms controlling ripple initiation behaving animals remain poorly understood. Here we combine multisite extracellular whole-cell recordings awake mice to contrast brain state modulation of subthreshold dynamics across hippocampal subfields. We find entorhinal input dentate gyrus (DG) exhibits UP DOWN with occurring exclusively...
ABSTRACT To flexibly navigate, many animals rely on internal spatial representations that persist when the animal is standing still in darkness, and update accurately by integrating animal’s movements absence of localizing sensory cues. Theories mammalian head direction cells have proposed these dynamics can be realized a special class networks maintain localized bump activity via structured recurrent connectivity, shift this angular velocity input. Although there are different variants...
ABSTRACT Hippocampal ripples are transient population bursts that structure cortico-hippocampal communication and play a central role in memory processing. However, the mechanisms controlling ripple initiation behaving animals remain poorly understood. Here we combine multisite extracellular whole cell recordings awake mice to contrast brain state modulation of subthreshold dynamics across hippocampal subfields. We find entorhinal input DG exhibits UP DOWN with occurring exclusively states....