A5072181104- Cutaneous Melanoma Detection and Management
- Health Literacy and Information Accessibility
- Misinformation and Its Impacts
- Artificial Intelligence in Healthcare and Education
- Optical Coherence Tomography Applications
- Eosinophilic Disorders and Syndromes
- Liver Disease and Transplantation
- Nonmelanoma Skin Cancer Studies
- Liver Disease Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Hair Growth and Disorders
- Cancer Treatment and Pharmacology
- Pain Management and Treatment
- Cutaneous lymphoproliferative disorders research
- Bariatric Surgery and Outcomes
- Cancer and Skin Lesions
- Social Media in Health Education
- Drug-Induced Adverse Reactions
- Lung Cancer Diagnosis and Treatment
- Infectious Diseases and Mycology
- Wound Healing and Treatments
- Photodynamic Therapy Research Studies
- Meta-analysis and systematic reviews
- Sexual function and dysfunction studies
- Prostate Cancer Treatment and Research
Yale Cancer Center
2025
Memorial Sloan Kettering Cancer Center
2021-2024
SUNY Downstate Health Sciences University
2023-2024
State University of New York
2023-2024
Yale University
2024
Advanced Dermatology
2024
University of Illinois Chicago
2018-2023
Kettering University
2021
University of Illinois Hospital & Health Sciences System
2018
University of Hawaiʻi at Mānoa
2012
Importance Consumers are increasingly using artificial intelligence (AI) chatbots as a source of information. However, the quality cancer information generated by these has not yet been evaluated validated instruments. Objective To characterize and presence misinformation about skin, lung, breast, colorectal, prostate cancers 4 AI chatbots. Design, Setting, Participants This cross-sectional study assessed chatbots’ text responses to 5 most commonly searched queries related common Search data...
Patients with prostate cancer (PCa) treated apalutamide frequently develop rash. We aim to characterize apalutamide-related dermatological adverse events (dAEs) and management.We assessed 303 patients PCa apalutamide. DAE frequency time onset were calculated clinicopathological features management described. Associations between dAE occurrence clinical trial participation, as well abiraterone/prednisone exposure detected using logistic regression models.Seventy-one (23.4%) had all-grade...
Metastasis drives mortality and morbidity in cancer. While some patients develop broad metastatic disease across multiple organs, others exhibit organ-specific spread. To identify mechanisms underlying organotropism, we analyzed clinico-genomic data from over 7,000 with cutaneous melanoma three independent cohorts (one primary discovery two validation including a nationwide electronic health record-derived deidentified database), leveraging machine learning approaches to clinical data. We...
Kidney stones are common and morbid conditions in the general population with a rising incidence globally. Previous studies show substantial limitations of online sources information regarding prevention treatment. The objective this study was to examine quality on kidney from artificial intelligence (AI) chatbots.
Table S1 Inputs into AI chatbots. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
Importance The mainstream use of chatbots requires a thorough investigation their readability and quality information. Objective To identify differences in information between free paywalled chatbot cancer-related responses, to explore if more precise prompting can mitigate any observed differences. Design, Setting, Participants This cross-sectional study compared chatbot’s vs responses with Google Trends’ top 5 search queries associated breast, lung, prostate, colorectal, skin cancers from...
The reflectance confocal microscopy (RCM)-optical coherence tomography (OCT) device has shown utility in detecting and assessing the depth of basal cell carcinoma (BCC) vivo but is challenging for novices to interpret. Artificial intelligence (AI) applied RCM-OCT could aid readers. We trained AI models, using OCT rasters biopsy-confirmed BCC, detect create three-dimensional rendering automatically measure tumour depth. Trained models were a separate test set containing benign lesions,...
Photodynamic therapy (PDT) with topical δ-Aminolevulinic acid (ALA) has efficacy in treating basal cell carcinoma (BCC) but is limited by incomplete penetration of ALA into the deeper dermis. This prospective open-label pilot trial investigated safety and photosensitizer jet injection for PDT (JI-PDT) BCC treatment. It was performed 15 patients (n = 15) histologically confirmed, untreated, low-risk nodular BCCs at a single institution.
Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute syndrome, and often seen in states associated with high systemic estrogen levels such pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result increased similar to those documented use, there are no reported cases of spontaneous therapy. We describe 53-year-old female who developed two dissections while on The patient had other risk factors for dissection. After...
12022 Background: Late alopecia is defined as incomplete hair regrowth > 6 months following cytotoxic chemotherapy or from initiation of endocrine therapy. It has been reported in up to 25-30% cancer survivors and associated with decreased quality life reduced dose intensity therapies. Minoxidil an aminopyridine potassium channel opener, resulting vasodilation premature entry resting follicles into the anagen (growth) phase increase follicle size. This study aims assess clinical outcomes...
<h3>Background</h3> While certain sites of metastatic melanoma are associated with worse outcomes after immunotherapy, such as brain and liver, parsimonious models to risk stratify disease describe patterns progression notwell established.<sup>1 2</sup> Risk stratification patients advanced remains paramount weigh the benefits ipilimumab+nivolumab (ipi/nivo) its increased toxicity compared anti-PD1 monotherapy.<sup>3</sup> In this study, we aim identify different phenotypes melanoma....
The Reflectance Confocal Microscopy – Optical Coherence Tomography (RCM-OCT) device has demonstrated its effectiveness in the vivo detection and depth assessment of basal cell carcinoma (BCC), though interpretation can be challenging for novices. Artificial intelligence (AI) potential to assist identifying BCC measuring these images. Our goal was develop an AI model capable generating 3D volumetric representations enhance measurement. We developed models trained on OCT images...
Abstract Background: Eosinophil-related cutaneous adverse events (ercAEs) are common toxicities of PI3K inhibitors, antibody drug conjugates (ADCs), checkpoint inhibitors (CPIs), and targeted cancer therapies. While systemic corticosteroids effective, their use is limited by additional high recurrence. Benralizumab an anti-IL-5Rα monoclonal that induces eosinophil depletion via antibody-dependent cellular cytotoxicity, FDA-approved for severe eosinophilic asthma but has not been studied...
e23230 Background: With a rapidly increasing number of candidate drugs and clinical trials in oncology, efficiency trial execution has become primary focus area for innovation. Currently, fewer than 5% oncology patients enroll trials, data suggests lack diversity patient populations compared to the broader demographic. To address these issues, we developed systematic unbiased pre-screening platform all patients. This approach holds promise hastening by enhancing identification eligible...
Gastrointestinal bleeding in patients with surgically altered anatomy such as Roux-en-Y gastric bypass (RYGB) may be challenging diagnosis and treatment. Conventional endoscopic techniques, esophagogastroduodenoscopy (EGD), are usually capable of identifying bleeds within the roux limb bypass; however, reaching jejunojejunal anastomosis or excluded stomach typically requires deep enteroscopy. We describe first report acute variceal a cause hemorrhage after RYGB surgery. A 53-year-old woman...
12100 Background: Rash associated with increased peripheral eosinophils develops in approximately 50% of metastatic breast cancer patients receiving alpelisib. Antihistamines and corticosteroids have limited benefit. Refractory rash may lead to decreased dose intensity affect clinical outcome. Benralizumab is an anti-IL-5Rα chimeric monoclonal antibody that depletes has demonstrated benefit eosinophilic asthma hypereosinophilic syndrome. We investigate the efficacy safety benralizumab for...
Introduction: Gastroesophageal varices (GOV) due to sinistral (left-sided) portal hypertension (SPH) is a rare, but life-threatening etiology of upper gastrointestinal bleeding (UGIB). SPH differentiated from other forms (PHT) by patent vein and preserved hepatic function. Pancreaticoduodenectomy (PD) has been associated with the development late complications including SPH. We describe case patient complex surgical history who presents UGIB secondary Case Description/Methods: present...
Abstract Background: Cutaneous Metastases (CM) are an infrequent presentation of advanced solid tumors and usually associated with symptoms pain, pruritus, secondary infections, all which negatively affect quality life result in additional morbidity. Systemic chemotherapy, wound care, topical agents, cryo-, electro-, photodynamic-, laser intralesional therapies have been limited by inconsistent efficacy, inconvenience, or toxicity. In this open-label phase 1/2 clinical trial, submicron...
Introduction: Vasoactive intestinal peptide secreting tumors (VIPomas) are rare, functioning neuroendocrine that can lead to a syndrome of high-volume watery diarrhea, electrolyte disturbances, acidosis and severe dehydration. Currently, the use somatostatin analogs is effective in reducing symptom burden when surgical intervention cannot be performed. Nonetheless, more robust studies management VIPomas currently lacking. Here, we discuss lithium as potential adjunctive treatment for...