A5045976132- Plant Molecular Biology Research
- Plant Reproductive Biology
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- Photosynthetic Processes and Mechanisms
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- Plant-Microbe Interactions and Immunity
- Light effects on plants
- Plant Physiology and Cultivation Studies
University of Tübingen
2019-2024
Università degli Studi della Tuscia
2022
Max Planck Institute for Developmental Biology
2017
University of Lausanne
2009-2011
A central question in developmental biology is how multicellular organisms coordinate cell division and differentiation to determine organ size. In Arabidopsis roots, this balance controlled by cytokinin-induced expression of SHORT HYPOCOTYL 2 ( SHY2 ) the so-called transition zone meristem, where negatively regulates auxin response factors (ARFs) protein–protein interaction. The resulting down-regulation PIN-FORMED PIN efflux carriers considered key event promoting meristematic cells. Here...
In Arabidopsis, interplay between nuclear auxin perception and trans-cellular polar transport determines the transcriptional response. brevis radix (brx) mutants, this response is impaired, probably indirectly because of disturbed crosstalk brassinosteroid pathways. Here we provide evidence that BRX protein plasma membrane-associated, but translocates to nucleus upon treatment modulate cellular growth, possibly in conjunction with NGATHA class B3 domain-type transcription factors....
Cytokinins propagate signals via multiple phosphorelays in a mechanism similar to bacterial two-component systems. In Arabidopsis, signal outputs are determined by the activation state of transcription factors termed type-B Arabidopsis response regulators (ARRs); however, their regulatory mechanisms largely unknown. this study, we demonstrate that proteolysis ARR2, ARR, modulates cytokinin signaling outputs. ARR2-hemagglutinin (HA) is rapidly degraded treatment, but other ARRs, such as...
Brassinosteroids (BR) are key hormonal regulators of plant development. However, whereas the individual components BR perception and signaling well characterized experimentally, question how they can act whether sufficient to carry out critical function cellular elongation remains open. Here, we combined computational modeling with quantitative cell physiology understand dynamics plasma membrane (PM)-localized response pathway during initiation responses in epidermis
• BREVIS RADIX (BRX) has been identified through a loss-of-function allele in the Umkirch-1 accession natural variation screen for Arabidopsis root growth vigor. Physiological and gene expression analyses have suggested that BRX is rate limiting auxin-responsive by mediating cross-talk with brassinosteroid pathway, as impaired reduced auxin perception of brx can be (partially) rescued external application. Using genetic tools, we show mutants also display significantly cotyledon leaf growth....
As regulators of gene expression in multicellular organisms, microRNAs (miRNAs) are crucial for growth and development. Although a plethora factors involved their biogenesis action Arabidopsis (Arabidopsis thaliana) has been described, these processes fine-tuning not fully understood. Here, we used plants expressing an artificial miRNA target mimic (MIM) to screen negative miR156. We identified new mutant allele the F-box HAWAIIAN SKIRT (HWS; At3G61590), hws-5, as suppressor MIM156-induced...
In plants, developmental plasticity allows for the modulation of organ growth in response to environmental cues. Being contact with soil, roots are first that responds various types soil abiotic stress such as high salt concentration. root, relies on changes activity apical meristem, region at tip root where a set self-renewing undifferentiated stem cells sustain growth. Here, we show promotes differentiation meristem via reducing dosage microRNAs miR165 and 166. By means genetic, molecular...
High-throughput single cell RNA-sequencing (scRNA-seq) is becoming a cornerstone of developmental research, providing unprecedented power in understanding dynamic processes. Here, we present high-resolution scRNA-seq expression atlas the Arabidopsis root, composed thousands independently profiled cells. This provides precise spatiotemporal information, identifying defining features for all major types, including scarce cells quiescent centre. These reveal new regulators and downstream genes...
Abstract Brassinosteroids (BR) are key hormonal regulators of plant development. However, whereas the individual components BR perception and signaling well characterized experimentally, question how they can act whether sufficient to carry out critical function cellular elongation remains open. Here, we combined computational modeling with quantitative cell physiology understand dynamics plasma membrane (PM)-localized response pathway during initiation responses in epidermis Arabidopsis...
Abstract In plants, developmental plasticity allows for the modulation of organ growth in response to environmental cues. Being contact with soil, roots are first responding soil abiotic stresses such as high salt concentration. root, relies on changes activity apical meristem, region at tip root where a set self-renewing undifferentiated stem cells sustains growth. We show that stress promotes meristem differentiation via reducing dosage microRNAs miR165 and 166. By means genetic, molecular...