A5048139288- Diabetes and associated disorders
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Blood donation and transfusion practices
- Obesity and Health Practices
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Blood properties and coagulation
- COVID-19 and healthcare impacts
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Nutrition and Health in Aging
- Diabetes Management and Research
- Mesenchymal stem cell research
- Venous Thromboembolism Diagnosis and Management
- Dietetics, Nutrition, and Education
- Immunotherapy and Immune Responses
- Erythropoietin and Anemia Treatment
- Acute Lymphoblastic Leukemia research
- Autopsy Techniques and Outcomes
- Organ Donation and Transplantation
University of British Columbia
2005-2024
Vancouver General Hospital
2021-2023
Child and Family Research Institute
2007
British Columbia Children's Hospital
2001-2006
Emory University Hospital
2004
Simon Fraser University
2000-2003
BC Research (Canada)
2003
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic β cells by T lymphocytes. Prediction cell-mediated autoimmune diseases direct detection autoreactive in peripheral blood has proved elusive, part because their low frequency and reduced avidity for peptide MHC ligands.
Abstract CTLs are important mediators of pancreatic β cell destruction in the nonobese diabetic mouse model type 1 diabetes. Cross-presentation Ag is one means priming CTLs. The death Ag-bearing cells has been implicated facilitating this mode priming. role onset spontaneous autoimmune diabetes unknown. Here, we used an adoptive transfer system to determine time course islet-derived presentation naive cell-specific CD8 T mice and test hypothesis that enhances autoantigen. We have determined...
Abstract Autoimmune (type 1) diabetes results from a loss of β cells that is mediated by self-reactive T cells. Previous studies have shown single injection CFA prevents in nonobese diabetic (NOD) mice, but the mechanism(s) protection remain unknown. We show here NOD mice immunized with markedly reduced incidence and this associated decrease number cell-specific, autoreactive CTL. In addition, adoptive transfer into syngeneic NOD/SCID recipients was prevented immunization, protective effects...
Abstract Activated T cells and their naive precursors display different functional avidities for peptide/MHC, but are thought to have identical antigenic repertoires. We show that, following activation with a cognate mimotope (NRP), diabetogenic CD8+ expressing single TCR (8.3) respond vigorously numerous peptide analogs of NRP that were unable elicit any responses from 8.3-CD8+ cells, even at high concentrations. The NRP-reactive, in vivo activated arising pancreatic islets nonobese...
BACKGROUND The optimal method of providing transfusion medicine (TM) education has not been determined. Transfusion Camp was established in 2012 at the University Toronto as a centrally delivered TM program for postgraduate trainees. impact on knowledge, attitudes, and self‐reported behavior evaluated. METHODS Didactic lectures (delivered locally, by webinar, or recorded) locally facilitated team‐based learning seminars were over 5 days during academic year to 8 sites: 7 Canada 1 United...
The optimal method of postgraduate transfusion medicine (TM) education remains understudied. One novel approach is Transfusion Camp, a longitudinal 5-day program that delivers TM to Canadian and international trainees. purpose this study was determine the self-reported impact Camp on trainee clinical practice.A retrospective analysis anonymous survey evaluations from trainees over three academic years (2018-2021) conducted. Trainees were asked, "Have you applied any your learning into...
ABSTRACT Pain is a subjective experience that affected by physical, emotional, and psychological factors, reliable assessment of pain can be challenge in the pediatric population. A quality improvement project was conducted at one Canadian health care facility to examine effectiveness postoperative management strategy for children admitted postanesthesia unit (PACU). Effective control involves several preventive strategies include preoperative analgesia, appropriate use intraoperative...
In March 2020, a state of emergency was declared to facilitate organized responses the coronavirus disease 2019 (COVID-19) pandemic in British Columbia, Canada. Emergency blood management committees (EBMCs) were formed regionally and provincially coordinate transfusion service activities possible national shortages. We describe services COVID-19 regional health authorities Columbia through collaborative survey, contingency planning meeting minutes, policy documents, including early trends...
The coronavirus disease 2019 (COVID-19) pandemic raised concerns about the vulnerability of platelet supply and uncertain impact resumption elective surgery on utilization. We report COVID-19 utilization across a large, integrated healthcare system in Canadian province British Columbia (BC).Historical use BC by indication was compiled for fiscal year 2010/2011-2019/2020. Platelet collections, initial daily inventory disposition data were assessed pre-COVID-19 (1 April 2018-15 March 2020) two...
You have accessJournal of UrologyHealth Services Research: Quality Improvement & Patient Safety II (MP33)1 May 2024MP33-19 A TRANSFUSION DASHBOARD INITIATIVE SAFELY REDUCES UNNECESSARY GROUP AND SCREEN TESTING FOR ENDOUROLOGIC PROCEDURES Ghizlane Moussaoui, Jacqueline D. Trudeau, Emma Pienaar, and Connor M. Forbes MoussaouiGhizlane Moussaoui , TrudeauJacqueline Trudeau PienaarEmma Pienaar ForbesConnor View All Author Informationhttps://doi.org/10.1097/01.JU.0001009520.30626.80.19AboutPDF...
Studies have described poor transfusion medicine (TM) knowledge in postgraduate trainees. The impact of undergraduate medical TM education on is unclear.