A5078179592- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
- Cardiac tumors and thrombi
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Muscle Physiology and Disorders
- Chronic Kidney Disease and Diabetes
- Pluripotent Stem Cells Research
- Vascular anomalies and interventions
Keio University
2010-2024
McGill University Health Centre
2020-2024
Jewish General Hospital
2024
St. Luke's International Hospital
2024
McGill University
2021-2023
Ashikaga Red Cross Hospital
2015-2021
Mount Sinai Beth Israel
2020
Icahn School of Medicine at Mount Sinai
2020
National Center for Global Health and Medicine
2018
Keio University Hospital
2015-2017
Despite the accumulating genetic and molecular investigations into hypertrophic cardiomyopathy (HCM), it remains unclear how this condition develops worsens pathologically clinically in terms of genetic-environmental interactions. Establishing a human disease model for HCM would help to elucidate these mechanisms; however, cardiomyocytes from patients are not easily obtained basic research. Patient-specific induced pluripotent stem cells (iPSCs) potentially hold much promise deciphering...
Background Scarce data exist about the outcomes after percutaneous coronary intervention ( PCI ) in old patients. This study sought to provide an overview of elderly patients, especially nonagenarians, a Japanese large prospective nationwide registry. Methods and Results We analyzed 562 640 patients undergoing (≥60 years age) from 1018 hospitals between 2014 2016 J-PCI (Japanese intervention) Among them, 10 628 (1.9%), including 6780 (1.2%) with acute syndrome ACS 3848 (0.7%) stable artery...
Although baseline hemoglobin and renal function are both important predictors of adverse outcomes after percutaneous coronary intervention (PCI), scarce data exist regarding the combined impact these factors on outcomes. We sought to investigate threshold value creatinine (Hgb/Cr) ratio, in-hospital among non-dialysis patients in a Japanese nationwide registry. analyzed 157,978 who underwent PCI 884 medical institutions 2017. studied differences characteristics clinical four groups according...
Mitochondrial diseases are heterogeneous disorders, caused by mitochondrial dysfunction. Mitochondria not regulated solely nuclear genomic DNA but DNA. It is difficult to develop effective therapies for disease because of the lack models. myopathy, encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) one major diseases. The aim this study was generate MELAS-specific induced pluripotent stem cells (iPSCs) demonstrate that MELAS-iPSCs can be models disease. We successfully...
Abstract In schizophrenia (SCZ) and autism spectrum disorder (ASD), the dysregulation of glutamate transmission through N -methyl- d -aspartate receptors (NMDARs) has been implicated as a potential etiological mechanism. Previous studies have accumulated evidence supporting NMDAR-encoding genes' role in etiology SCZ ASD. We performed screening study for exonic regions GRIN1 , GRIN2A GRIN2C GRIN2D GRIN3A GRIN3B which encode NMDAR subunits, 562 participates (370 192 ASD). Forty rare variants...
SCN5A is abundant in heart and has a major role INa. Loss-of-function mutation results Brugada syndrome (BrS), which causes sudden death adults. It remains unclear why disease phenotype does not manifest the young even though mutated expressed young. The aim of present study to elucidate timing manifestation BrS. A gain-of-function also Long QT type 3 (LQTS3), leading Induced pluripotent stem cells (iPSCs) were generated from patient with mixed LQTS3 BrS E1784K mutation. Here we show that...
Duchenne muscular dystrophy (DMD) is a chronic and life-threatening disease that initially supported by muscle regeneration but eventually shows satellite cell exhaustion dysfunction. The life-long maintenance of skeletal homoeostasis requires the stem pool to be preserved. Asymmetric division plays pivotal role in pool. Here we show granulocyte colony-stimulating factor receptor (G-CSFR) asymmetrically expressed activated cells. G-CSF positively affects population during multiple stages...
Andersen-Tawil syndrome (ATS) is a rare inherited channelopathy. The cardiac phenotype in ATS typified by prominent U wave and ventricular arrhythmia. An effective treatment for this disease remains to be established. We reprogrammed somatic cells from three patients generate induced pluripotent stem (iPSCs). Multi-electrode arrays (MEAs) were used record extracellular electrograms of iPSC-derived cardiomyocytes, revealing strong arrhythmic events the ATS-iPSC-derived cardiomyocytes. Ca2+...
Abstract Alteration of the nuclear Ca 2+ transient is an early event in cardiac remodeling. Regulation partly independent cytosolic cardiomyocytes. One membrane protein, emerin, encoded by EMD, and EMD mutation causes Emery-Dreifuss muscular dystrophy (EDMD). It remains unclear whether emerin involved homeostasis. The aim this study to elucidate role rat cardiomyocytes means hypertrophic stimuli EDMD induced pluripotent stem (iPS) cell-derived terms structure transient. increased area,...
Induced pluripotent stem cells (iPSCs) have been proposed as novel cell sources for genetic disease models and revolutionary clinical therapies. Accordingly, human iPSC-derived cardiomyocytes are potential cardiomyocyte transplantation therapy. We previously developed a generation method peripheral T cell-derived iPSCs (TiPSCs) that uses minimally invasive approach to obtain patient cells. However, it remained unknown whether TiPSCs with genomic rearrangements in the receptor (TCR) gene...
Background:Percutaneous closure has replaced surgery for the majority of cases secundum atrial septal defect (ASD). However, technological advances have made contemporary minimally invasive cardiac (MICS) less than conventional surgery. The aim this study was to compare clinical outcomes percutaneous ASD with those MICS.
Abstract Objectives This study sought to provide an overview of percutaneous coronary intervention (PCI) in dialysis patients from a Japanese nationwide registry. Background Little is known about undergoing PCI because few are enrolled clinical trials. Methods We analyzed 624,900 cases including 41,384 (6.6%) 1,017 hospitals between 2014 and 2016. investigated differences characteristics in‐hospital outcomes nondialysis patients, assessed factors associated with increased risk adverse...