Alexander Morales

ORCID: 0000-0002-7347-1159
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About
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Research Areas
  • Drug-Induced Adverse Reactions
  • Dialysis and Renal Disease Management
  • Renal and related cancers
  • Chemotherapy-related skin toxicity
  • Central Venous Catheters and Hemodialysis
  • Pharmaceutical studies and practices
  • Chronic Kidney Disease and Diabetes
  • Health and Lifestyle Studies
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Muscle and Compartmental Disorders
  • Antifungal resistance and susceptibility
  • Atrial Fibrillation Management and Outcomes
  • Infectious Diseases and Mycology
  • Diet and metabolism studies
  • Pharmacological Effects and Toxicity Studies
  • Thermoregulation and physiological responses
  • Diabetes and associated disorders
  • HIV/AIDS drug development and treatment
  • Cardiovascular Health and Disease Prevention
  • Diabetes Treatment and Management
  • Heart Rate Variability and Autonomic Control
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Lung Cancer Treatments and Mutations
  • Single-cell and spatial transcriptomics
  • Diabetes Management and Research

Beth Israel Deaconess Medical Center
2020-2024

Harvard University
2020

Memorial Hospital of Rhode Island
2017

Brown University
2017

University of Caldas
2007

Debora L. Gisch Michelle Brennan Blue B. Lake Jeannine Basta Mark S. Keller and 95 more Ricardo Melo Ferreira Shreeram Akilesh Reetika Ghag Charles Lu Ying‐Hua Cheng Kimberly S. Collins Samir V. Parikh Brad H. Rovin Lynn W. Robbins Lisa Stout Kimberly Y. Conklin Dinh Diep Bo Zhang Amanda Knoten Daria Barwinska Mahla Asghari Angela R. Sabo Michael J. Ferkowicz Timothy A. Sutton Katherine J. Kelly Ian H. de Boer Sylvia E. Rosas Krzysztof Kiryluk Jeffrey B. Hodgin Fadhl Alakwaa Seth Winfree Nichole Jefferson Aydın Türkmen Joseph P. Gaut Nils Gehlenborg Carrie L. Phillips Tarek M. El‐Achkar Pierre C. Dagher Takashi Hato Kun Zhang Jonathan Himmelfarb Matthias Kretzler Shamim Mollah Blue B. Lake Alexander Morales Isaac E. Stillman Stewart H. Lecker Steve Bogen Ashish Verma Guanghao Yu Insa M. Schmidt Joel Henderson Laurence H. Beck Pranav Yadati Sushrut S. Waikar Afolarin Amodu Shana Maikhor Titlayo Ilori Mia R. Colona Astrid Weins Gearoid M. McMahon Nir Hacohen Anna Greka Jamie L. Marshall Paul Hoover Vidya Sankar Viswanathan Dana C. Crawford Mark P. Aulisio William S. Bush Yijiang Chen Anant Madabhushi Charles M. O’Malley Crystal A. Gadegbeku Dianna Sendrey Emilio D. Poggio John O’Toole John R. Sedor Jonathan J. Taliercio Lakeshia Bush Leal Herlitz Ellen L. Palmer Jane Nguyen Kassandra Spates-Harden Leslie Cooperman Stacey E. Jolly Carissa Vinovskis Andrew S. Bomback Jonathan Barasch Krzysztof Kiryluk Paul S. Appelbaum Vivette D. D’Agati Cecilia Berrouet Karla Mehl Maya Sabatello Ning Shang Olivia Balderes Pietro A. Canetta Satoru Kudose Joana P. Gonçalves Lukasz G. Migas

There is a need to define regions of gene activation or repression that control human kidney cells in states health, injury, and repair understand the molecular pathogenesis disease design therapeutic strategies. Comprehensive integration expression with epigenetic features regulatory elements remains significant challenge. We measure dual single nucleus RNA chromatin accessibility, DNA methylation, H3K27ac, H3K4me1, H3K4me3, H3K27me3 histone modifications decipher landscape regulation...

10.1038/s41467-023-44467-6 article EN cc-by Nature Communications 2024-01-10
Tarek M. El‐Achkar Michael T. Eadon Matthias Kretzler Jonathan Himmelfarb Blue B. Lake and 95 more Kun Zhang Stewart H. Lecker Alexander Morales Steve Bogen Afolarin Amodu Laurence H. Beck Joel Henderson Titlayo Ilori Shana Maikhor Ingrid Onul Insa M. Schmidt Ashish Verma Sushrut S. Waikar Pranav Yadati Guanghao Yu Mia R. Colona Gearoid M. McMahon Nir Hacohen Anna Greka Paul Hoover Jamie L. Marshall Mark P. Aulisio William S. Bush Yijiang Chen Dana C. Crawford Anant Madabhushi Vidya Sankar Viswanathan Lakeshia Bush Leslie Cooperman Crystal A. Gadegbeku Leal Herlitz Stacey E. Jolly Jane Nguyen Charles M. O’Malley John O’Toole Ellen L. Palmer Emilio D. Poggio Kassandra Spates-Harden John R. Sedor Dianna Sendrey Jonathan J. Taliercio Paul S. Appelbaum Olivia Balderes Jonathan Barasch Cecilia Berroue Andrew S. Bomback Pietro A. Canetta Vivette D. D’Agati Krzysztof Kiryluk Satoru Kudose Karla Mehl Maya Sabatello Ning Shang Joana P. Gonçalves Roy Lardenoije Lukasz G. Migas Raf Van de Plas Helmut G. Rennke Evren U. Azeloglu Kirk N. Campbell Steven G. Coca Cijang He John Cijiang He Srinivas Ravi Iyengar Seanee Lefferts Girish N. Nadkarni Marissa Patel Joji Tokita Stephen A. Ward Yuguang Xiong Abraham Verdoes Angela R. Sabo Daria Barwinska Debora L. Gisch James C. Williams Katherine J. Kelly Kenneth W. Dunn Mahla Asghari Michael T. Eadon Michael J. Ferkowicz Pierre C. Dagher Ricardo Melo Ferreira Seth Winfree Sharon B. Bledsoe Stephanie Wofford Tarek M. El‐Achkar Timothy A. Sutton William S. Bowen Ying‐Hua Cheng Austen Slade Elizabeth Record Ying‐Hua Cheng Katy Börner Bruce Herr Yashvardhan Jain

10.1053/j.ajkd.2023.08.015 article EN publisher-specific-oa American Journal of Kidney Diseases 2023-10-13

Although a litany of pharmacotherapeutic agents has been implicated in drug-induced lactic acidosis, the expanding use nucleoside/nucleotide reverse transcription inhibitors (NRTIs) makes this class drugs increasingly important for nephrology awareness. Once used primarily HIV treatment,

10.2215/cjn.14781219 article EN Clinical Journal of the American Society of Nephrology 2020-05-22

BackgroundA 17 year old patient was referred to Allergy outpatient clinic with history of recent anaphylaxis (wheezing, breathlessness, nausea, vomit and hypotension) methotrexate (MTX) during the induction treatment ALL L2. The diagnostic confirmation consisted in a skin test, positive

10.1097/01.wox.0000412157.09242.5f article EN cc-by-nc-nd World Allergy Organization Journal 2012-02-01

Background Sleep-disordered breathing (SDB) has been studied in obese adults but there are few studies on adolescents. This study analyzed the frequency of SDB adolescents and controls with without asthma. Methods A cross-sectional comparative study, 27 10 to 18 years old body mass index (BMI) ≥ 95th percentile, whom 17 (43%) had mild intermittent asthma (MIA) according GINA 2005 guidelines 23 (57%) asthma, plus a group 20 eutrophics (BMI = percentile 50th–84th), 50% (n 10) MIA healthy. All...

10.1097/01.wox.0000412066.14667.e2 article EN cc-by-nc-nd World Allergy Organization Journal 2012-02-01

El diagnostico de la paciente fue coccidioido-micosis pulmonar cronica, coccidioidomicosisextrapulmonar y meningoencefalitis porCoccidioides spp.ComentarioLa coccidioidomicosis es una infeccion micoticaque afecta forma primaria el parenquimapulmonar; en ocasiones, puede ser subclinicahasta convertirse enfermedad sistemicamuy letal (1). En esta con sospechadiagnostica clinica los hallazgos biopsiadel ganglio cervical se inicio manejo anfo-tericina B a dosis 0,7-1 mg/kg al dia; pesarde recibir...

10.7705/biomedica.v27i2.222 article ES publisher-specific-oa Biomédica 2007-08-17
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