A5008283426- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Axial and Atropisomeric Chirality Synthesis
- Quinazolinone synthesis and applications
- Catalytic C–H Functionalization Methods
- Glutathione Transferases and Polymorphisms
- Teleoperation and Haptic Systems
- Sulfur Compounds in Biology
- Hand Gesture Recognition Systems
- Laser and Thermal Forming Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Tuberculosis Research and Epidemiology
- Microwave Imaging and Scattering Analysis
- Catalytic Alkyne Reactions
- Ultrasound and Hyperthermia Applications
- Synthesis of heterocyclic compounds
- Genomics, phytochemicals, and oxidative stress
- Advanced Chemical Sensor Technologies
- Interactive and Immersive Displays
- Histone Deacetylase Inhibitors Research
Shanghai Institute of Materia Medica
2023
Northwestern Polytechnical University
2019-2022
Air Force Medical University
2020
Stanford University
2018
University of New Mexico
2010-2016
Southeast University
2016
East China University of Science and Technology
2013
Southeast University
2009-2012
University of North Carolina at Charlotte
2008
A dual-targeted fluorogenic probe and microfluidic chip enables single-cell labeling quantification of live Mycobacterium tuberculosis .
Control is better: A novel chiral amine thiourea catalyzed, highly enantioselective Michael–Michael cascade process serves as a "one-pot" approach to synthetically and biologically significant tetrahydrothiophenes (see scheme). Notably, an unprecedented cooperative direct stereocontrol dynamic kinetic resolution by the bifunctional catalyst identified that governs process. Detailed facts of importance specialist readers are published "Supporting Information". Such documents peer-reviewed,...
An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields enantioselectivities.
Abstract An asymmetric two‐step approach to chiral bridged tricyclic benzopyrans, core structures featured in various natural products, is described. In the synthesis, an unprecedented enantioselective catalytic decarboxylative Diels–Alder reaction developed using readily available coumarin‐3‐carboxylic acids and aldehydes as reactants under mild conditions. Notably, decarboxylation‐assisted release of catalyst enables process proceed efficiently with high enantio‐ diastereoselectivity....
An unprecedented simple pyrrolidine catalyzed [4 + 1] annulation reaction of ynals with N-protected-2-aminophenols is reported. The utilization the unique property and reactivity C≡C triple bond in leads to two consecutive conjugate addition reactions at same β-position via iminium activation. powerful cascade process affords a new alternative approach biologically synthetically important benzoxazoles high yields (83-95%).
Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and development of drug-resistance are proved to be important markers for various tumors. Different from previous probes, we developed a fluorescent probe enabling detection intracellular GSTs low GSH level environment by pre-treatment cells with thiol-scavengers.
Abstract Non‐invasive, real‐time, dynamic, and quantitative molecular imaging has been developed to facilitate disease diagnosis, drug development, pathological analysis at the level. Qualitative of physiological processes level can be achieved with advanced by employing contrast agents in combination traditional modalities, such as optical imaging, ultrasound magnetic resonance single‐photon emission computed tomography, positron tomography. With aid absorption, distribution, metabolism,...
Abstract An asymmetric two‐step approach to chiral bridged tricyclic benzopyrans, core structures featured in various natural products, is described. In the synthesis, an unprecedented enantioselective catalytic decarboxylative Diels–Alder reaction developed using readily available coumarin‐3‐carboxylic acids and aldehydes as reactants under mild conditions. Notably, decarboxylation‐assisted release of catalyst enables process proceed efficiently with high enantio‐ diastereoselectivity....
This paper addresses a largely open problem in haptic simulation and rendering: contact force deformation modeling for of grasping deformable object with realistic virtual human hand, especially power grasps. The hand model consists meshes shapes the finger links palm hand. We tackle by adopting non-linear beam-skeleton global shape introduced [5]. results verify efficiency both grasp precision objects reasonable realism.
Abstract GSTP1 has been considered to be a marker for malignancy in many tissues. However, the existing GST fluorescent probes are unfavorable vivo imaging because of limited emission wavelength or insufficient fluorescence enhancement (six‐fold). The is mainly ascribed high background signals resulting from spontaneous reaction between GSH and probes. In this work, highly specific probe with NIR successfully developed through optimization essential unit repress reaction. novel exhibits over...
Electrical properties of biological tissues are highly sensitive to their physiological and pathological status. Thus it is importance image electrical tissues. However, spatial resolution conventional impedance tomography (EIT) generally poor. Recently, hybrid imaging modalities combining electric conductivity contrast ultrasonic based on the acousto-electric effect has attracted considerable attention. In this study, we propose a novel three-dimensional (3D) noninvasive ultrasound Joule...
A relay strategy is described that permits ring-closing metathesis and bifunctional chiral amine (thio)urea-catalyzed Michael addition reactions to proceed in a one-pot fashion. The process offers an alternative approach the synthesis of structurally diverse cyclopentanes good yields enantioselectivities.
In China, attention to the education of measurement control and instrumentation has increased since 1997, when Measurement Control Instrumentation Specialty was redefined approved by Ministry Education China. The is a broad-range discipline involved with optics, mechanics, electronics computer technology. this paper, we introduce specialty-training goal curriculum for undergraduate students. We selected Southeast University in China as an example illustrate
While tangible user interface has shown its power in naturally interacting with rigid or soft objects, users cannot conveniently use different types of granular materials as the interaction media. We introduce DipMe a smart device to recognize media real time, which can be used connect physical world various virtual content. Other than vision-based solutions, we propose dip operation our and exploit haptic signals materials. With modern machine learning tools, find from are distinguishable...
In this paper, a new method to model the global deformation between rigid object and an elastic with hole is presented. This extends idea of beam-skeletons [10] by introducing curved cantilever beams for efficient modeling objects holes. The implemented tested on different examples. Results from three examples are given demonstrate efficiency effectiveness approach.
Abstract As the outbreak of Covid-19 pandemic, isopropyl alcohol (IPA) molecules played significant role as a biomarker for anti-virus diagnosis. However, conventional gas detection exhibited dramatic drawbacks, like strict working conditions ion mobility methodology and weak light-matter interaction mid-infrared spectroscopy, yielding limited response targeted molecules. We propose synergistic artificial intelligence (AI)-augmented spectroscopy(IMMS), leveraging complementary features from...
Abstract In some cases application of Grubbs first generation catalyst instead second upon the addition increases enantiomeric excess product.
Abstract Review: 27 refs.