A5042407893- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Prenatal Screening and Diagnostics
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- Cancer Genomics and Diagnostics
- COVID-19 and Mental Health
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Ethics and Legal Issues in Pediatric Healthcare
- Eosinophilic Esophagitis
- Chronic Myeloid Leukemia Treatments
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Patient-Provider Communication in Healthcare
Rigshospitalet
2016-2025
Copenhagen University Hospital
2023-2025
University of Copenhagen
2021-2025
University of Southern Denmark
2022
Business Innovation Centre
2022
Assistance Publique – Hôpitaux de Paris
2021
Inserm
2021
Abstract Reports of persistent symptoms after hospitalization with COVID-19 have raised concern a “long COVID” syndrome. This study aimed at determining the prevalence and risk factors for acute in non-hospitalized patients polymerase chain reaction (PCR) confirmed COVID-19. We conducted cohort participants identified via Danish Civil Registration System SARS-CoV-2-positive PCR-test available biobank samples. Participants received digital questionnaire on demographics COVID-19-related...
Abstract Mutations in the epigenetic modifier TET2 are frequent myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP) cytopenia undetermined significance (CCUS). Here, we investigate associations between mutations DNA methylation whole blood 305 elderly twins, 15 patients with CCUS 18 healthy controls. We find that associated hypermethylation at enhancer sites CHIP both granulocytes mononuclear cells CCUS. These hypermethylated leukocyte function immune response...
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Asparaginase-associated pancreatitis is a life-threatening toxicity to childhood acute lymphoblastic leukemia treatment. To elucidate genetic predisposition and asparaginase-associated pathogenesis, ten trial groups contributed remission samples from patients aged 1.0-17.9 years treated for between 2000 2016. Cases (n=244) were defined by the presence of at least two following criteria: (i) abdominal pain; (ii) levels pancreatic enzymes ≥3 × upper normal limit; (iii) imaging compatible with...
Summary Asparaginase is essential in childhood acute lymphoblastic leukaemia ( ALL ) treatment, however hypersensitivity reactions to pegylated asparaginase PEG ‐asparaginase) hampers anti‐neoplastic efficacy. Patients with ‐asparaginase have been shown possess zero enzyme activity. Using this measurement define the phenotype, we investigated genetic predisposition a genome‐wide association study GWAS ). From July 2008 March 2016, 1494 children were treated on Nordic Society of Paediatric...
Abstract Background Reports of persistent symptoms after hospitalization with COVID-19 have raised concern a “long COVID” syndrome. This study aimed at characterizing acute and in non- hospitalized patients polymerase chain reaction (PCR) confirmed COVID-19. Methods Cohort 445 non-hospitalized participants identified via the Danish Civil Registration System SARS-CoV-2-positive PCR-test available biobank samples for genetic analyses. Participants received digital questionnaire on demographics...
Abstract Aim To explore parents’ and adolescents’ motives for accepting/declining participation in the ALL 2008 trials involvement decision‐making process. Background Children adolescents with acute lymphoblastic leukaemia treated on Nordic Society of Paediatric Haematology Oncology protocol were eligible two randomizations testing 6‐mercaptopurine treatment intensifications to improve efficacy Asparaginase de‐escalation reduce toxicity. We recently reported that while favoured reduction,...
Clonal hematopoiesis of indeterminate potential (CHIP) is common in the elderly and has been reported to associate with accelerated epigenetic age (AgeAccel), especially intrinsic (ie, cell-type independent) AgeAccel a lesser degree extrinsic AgeAccel, which reflects immune-cell composition peripheral blood. We investigated association between CHIP occurrence 154 Danish twin pairs aged 73-90 years (mean 79), using both individual-level intrapair analyses, latter control for shared genetic...
This randomized controlled trial tested the hypothesis that children with non-high-risk acute lymphoblastic leukemia could benefit from individualized 6-mercaptopurine increments during consolidation therapy (NCT00816049). Primary and secondary end points were of minimal residual disease (MRD) positivity event-free survival.392 patients to experimental 396 standard therapy. Patients allocated received oral (25 mg/m2 /day) days 30 85, while arm stepwise additional 25 /day beginning on 50...
When offered participation in clinical trials, families of children with cancer face a delicate balance between cure and toxicity. Since parents may perceive this differently, paper explores whether adolescent patients have different enrollment patterns compared to younger trials toxicity profiles.Age-dependent rates three consecutive, randomized childhood leukemia conducted by the Nordic Society Paediatric Haematology Oncology were evaluated. The ALL2000 dexamethasone/vincristine (Dx/VCR)...
Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied.
Asparaginase-associated pancreatitis (AAP) frequently affects children treated for acute lymphoblastic leukemia (ALL) causing severe and persisting complications. Known risk factors such as asparaginase dosing, older age single nucleotide polymorphisms (SNPs) have insufficient odds ratios to allow personalized therapy. In this study, we explored machine learning strategies prediction of individual AAP risk. We integrated information on age, sex, SNPs based Illumina Omni2.5exome-8 arrays...
Abstract Bone marrow specimens are the core of diagnostic workup patients with cytopenia. To explore whether next-generation sequencing (NGS) could be used to rule out malignancy without bone specimens, we incorporated NGS in a model predict presence disease unexplained We analyzed occurrence mutations 508 cytopenia, referred for primary suspected hematologic from 2015 2020. divided into discovery (n = 340) and validation 168) cohort. Targeted sequencing, biopsy, complete blood count were...
6-mercaptopurine (6-MP) is widely used in the treatment of acute lymphoblastic leukemia (ALL), and its cytotoxicity primarily mediated by thioguanine nucleotide (TGN) metabolites. A recent genomewide association study has identified germline polymorphisms (e.g., rs72846714) NT5C2 gene associated with 6-MP metabolism patients ALL. However, full spectrum genetic variation unclear impact on drug activation not been comprehensively examined. To this end, we performed targeted sequencing 588...
IntroductionThromboembolism (TE) is a common and serious toxicity of acute lymphoblastic leukemia (ALL) treatment, but studies genetic predisposition have been underpowered with conflicting results. We tested whether TE in ALL the general adult population shared etiology.Materials methodsWe prospectively registered events collected germline DNA patients 1.0–45.9 years Nordic Society Pediatric Hematology Oncology (NOPHO) ALL2008 study (7/2008–7/2016). Based on summary statistics from two...
Clonal hematopoiesis of indeterminate potential (CHIP) refers to the nonmalignant clonal expansion blood stem cells that carry somatic mutations in myeloid cancer-associated genes.1 The main driver CHIP progression is age, but other factors like smoking or chemotherapy exposure can also have significant effects.2 has been associated with an increased risk hematological malignancies and a range age-related conditions, including severe infections death.1, 3 basis for this link suggested be...
Abstract Mosaic chromosomal alterations (mCAs) in hematopoietic cells increase mortality and risk of hematological cancers infections. We investigated the landscape mCAs their clinical consequences 976 patients with multiple myeloma undergoing high-dose chemotherapy autologous stem cell support (ASCT) median 6.4 years follow-up. were detected harvest product 158 (16.2%). Autosomal aberrations found 60 (6.1%) affected all chromosomes. Loss chromosome X was 51 females (12.7%) loss Y 55 males...
The adaptive immune response, and especially the role of T-cells has become a key focus in treatment lymphoma.The T-cell receptor (TCR) is exclusive for every clone thus provides unique information about condition system.Novel NGS sequencing made it possible to identify hundred thousands clones single sample, consequently termed TCR repertoire.Poorer diversity repertoire been associated with inferior outcomes other cancers [Thommen DS et al. -Cancer Cell 2018].We explored how systemic...