A5057947463- Trypanosoma species research and implications
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Amphibian and Reptile Biology
- Insect symbiosis and bacterial influences
- Bacteriophages and microbial interactions
- Species Distribution and Climate Change
- Lepidoptera: Biology and Taxonomy
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Genetic diversity and population structure
- Mosquito-borne diseases and control
- Antibiotic Resistance in Bacteria
- Plant and animal studies
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant and Fungal Interactions Research
- Fish Ecology and Management Studies
- Entomopathogenic Microorganisms in Pest Control
- Microbial infections and disease research
- Ecology and Vegetation Dynamics Studies
- Fish biology, ecology, and behavior
- Insect and Arachnid Ecology and Behavior
- Microbial Community Ecology and Physiology
Charles Darwin University
2024
University of California, Merced
2015-2023
Yale University
2012-2016
The University of Adelaide
2009-2014
South Australian Museum
2009-2013
Flinders University
2012
Macquarie University
2009
Abstract Increasing prevalence and severity of multi-drug-resistant (MDR) bacterial infections has necessitated novel antibacterial strategies. Ideally, new approaches would target pathogens while exerting selection for reduced pathogenesis when these bacteria inevitably evolve resistance to therapeutic intervention. As an example such a management strategy, we isolated lytic bacteriophage, OMKO1, (family Myoviridae ) Pseudomonas aeruginosa that utilizes the outer membrane porin M (OprM)...
The taxonomy of central Australian populations geckos the genus Gehyra has been uncertain since chromosomal studies carried out in 1970s and 1980s revealed considerable heterogeneity apparently independent patterns morphological karyotypic diversity. Following detailed molecular genetic studies, species boundaries this complex have become clearer we here re-set three named involved, G. variegata (Duméril & Bibron, 1836), montium Storr, 1982, nana King, describe new species. Two species,...
Plasmid sequences are central to a myriad of microbial functions and processes. Here, we have compiled database complete plasmid associated metadata curated from both NCBI's recent genome update, which includes plasmids as organisms, all available annotated bacterial genomes. The resultant contains 10,892 metadata.
Abstract Vibrio species are an emerging public and animal health risk in marine environments the opportunistic bacterial pathogen harveyi is a major disease for tropical aquaculture. Current understanding of virulence V. limited by strain-specific variability complex host-pathogen dynamics. This study sought to integrate genomic investigation, phenotypic characterisation vivo challenge trials barramundi ( Lates calcarifer) increase our virulence. We identified two hypervirulent isolates,...
Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms resisting the activity trypanosome lytic factors (TLFs), components innate immunity human serum that protect against infection by other trypanosomes. In Tbr, is suppressed Tbr-specific serum-resistance associated (SRA) protein. The mechanism Tbg less well understood but has been hypothesized to involve altered...
The Trypanosoma brucei complex contains a number of subspecies with exceptionally variable life histories, including zoonotic subspecies, which are causative agents human African trypanosomiasis (HAT) in sub-Saharan Africa.Paradoxically, genomic variation between taxa is extremely low.We analyzed the whole-genome sequences 39 isolates across T. from diverse hosts and regions, identifying 608,501 single nucleotide polymorphisms that represent 2.33% nuclear genome.We show pathogenicity occurs...
Virus populations may be challenged to evolve in spatially heterogeneous environments, such as mixtures of host cells that pose differing selection pressures. Spatial heterogeneity select for evolved polymorphisms, where multiple virus subpopulations coexist by specializing on a narrow subset the available hosts. Alternatively, spatial generalism, single genotype dominates population occupying relatively broader niche. In addition, extent should influence degree divergence among encountering...
Abstract This article documents the addition of 153 microsatellite marker loci to Molecular Ecology Resources Database. Loci were developed for following species: B rassica oleracea, rycon amazonicus, D imorphandra wilsonii, E upallasella percnurus, H elleborus foetidus, I pomoea purpurea, P hrynops geoffroanus, rochilodus argenteus, yura sp. , S ylvia atricapilla, T eratosphaeria suttonii, rialeurodes vaporariorum and rypanosoma brucei . These cross‐tested on coccicinea, cuprea,...
Background While Human African Trypanosomiasis (HAT) is in decline on the continent of Africa, disease still remains a major health problem Uganda. There are recurrent sporadic outbreaks traditionally endemic areas south-east Uganda, and continued spread to new unaffected central We evaluated evolutionary dynamics underpinning origin foci impact host species parasite genetic diversity genotyped 269 Trypanosoma brucei isolates collected from different regions Uganda southwestern Kenya at 17...
Oliver, P.M., Richards, S.J. & Sistrom, M. (2012). Phylogeny and systematics of Melanesia’s most diverse gecko lineage ( Cyrtodactylus , Gekkonidae, Squamata). — Zoologica Scripta 41 437–454. The biogeographical history the fauna New Guinea surrounding islands (Melanesia) remain poorly known. We present a phylogeny for 16 21 recognised Melanesian bent‐toed geckos in genus based on mitochondrial sequence data. These analyses reveal two divergent lineages within Melanesia. One includes...
Background Trypanosoma brucei is a eukaryotic pathogen which causes African trypanosomiasis. It notable for its variant surface glycoprotein (VSG) coat, undergoes antigenic variation enabled by large suite of VSG pseudogenes, allowing persistent evasion host adaptive immunity. While rhodesiense (Tbr) and T. b gambiense (Tbg) are human infective, related b. (Tbb) cleared sera. A single gene, the Serum Resistance Associated (SRA) confers Tbr infectivity phenotype. Potential genetic...
Increasing rates of antibiotic-resistant bacterial infection are one the most pressing contemporary global health concerns. The ESKAPE pathogen group represents leading cause these infections, and upregulation efflux pump expression is a significant mechanism resistance in pathogens. This has resulted substantial interest development inhibitors to combat infections; however, no widespread treatments have been developed date. Our study evaluates an often-underappreciated aspect resistance—the...
We provide the first phylogenetic hypothesis for Australian species of gekkonid genus Gehyra, based on 1044bp mitochondrial ND2 gene. Species representing Asian, Melanesian and radiations are resolved as separate clades, indicating relative isolation independence each these evolutionary lines. Within radiation, arid zone form a monophyletic subgroup distinct from remaining found in tropical warm mesic habitats. Extensive chromosome variation highly variable external morphology have made...
Abstract Body size affects life history, the ecological niche of an organism and its interactions with other organisms. Resultantly, marked differences in body between related organisms are often indication a species boundary. This is particularly evident Gehyra variegata complex geckos, which displays differential sizes genetically divergent species, but high levels intraspecific morphological conservatism. We report on population that extraordinary differentiation comparison G. species....
Abstract Motivation: When working with non-model organisms, few if any species-specific markers are available for phylogenetic, phylogeographic and population studies. Therefore, researchers often try to adapt developed in distantly related taxa, resulting poor amplification ascertainment bias their target taxa. Markers can be de novo anonymous nuclear loci (ANL) proving a boon seeking large numbers of fast-evolving, independent loci. However, the development ANL laboratory intensive...
Tsetse flies ( Glossina spp.) are the sole vectors of Trypanosoma brucei —the agent human (HAT) and animal (AAT) trypanosomiasis. fuscipes Gff ) is main vector species in Uganda—the only country where two forms HAT disease rhodesiense gambiense occur, with limited to northwest. populations cluster three genetically distinct groups northern, southern, western Uganda, respectively, a contact zone present central Uganda. Understanding dynamics this epidemiologically important as merger diseases...
detailed examination of larger series specimens and exploration poorly collected areas in Australia the Pacifi c, have
Pseudomonas syringae pv. phaseolicola (Pph) is a significant bacterial pathogen of agricultural crops, and phage Φ6 other members the dsRNA virus family Cystoviridae undergo lytic (virulent) infection Pph, using type IV pilus as initial site cellular attachment. Despite popularity Pph/phage model system in evolutionary biology, Pph resistance to remains poorly characterized. To investigate differences between resistant strains, we examined genomic gene expression variation among three...
The trypanosome Trypanosoma brucei gambiense (Tbg) is a cause of human African trypanosomiasis (HAT) endemic to many parts sub-Saharan Africa. disease almost invariably fatal if untreated and there no vaccine, which makes monitoring managing drug resistance highly relevant. A recent study HAT cases from the Democratic Republic Congo reported high incidence relapses in patients treated with melarsoprol. Of 19 Tbg strains isolated enrolled this study, four pairs were obtained same patient...
African trypanosomes of the sub-genus Trypanozoon) are eukaryotic parasitesthat cause disease in either humans or livestock. The development genomic resources can be great use to those interested studying and controlling spread these trypanosomes. Here we present a large comparative analysis Trypanozoon whole genomes, 83 total, including human animal infective trypanosomes: 21 T. brucei brucei, 22 b. gambiense, 35 rhodesiense 4 evansi strains, which were from Uganda. We constructed maximum...
Gehyra barea is a poorly known gecko species from the southern Banda Islands, Maluku Province, Indonesia, that has received scant attention since it was described in 1926. A combination of morphological characters distinguish types this all other Gehyra, and suggest distinct taxon. These same occur two recently collected specimens Raja Ampat just off west coast New Guinea, we assign to species, extending range taxon by over six hundred kilometres. We provide revised extended diagnosis...
Abstract The evolutionary history of Amazonian organisms is generally poorly understood. This particularly true for small floodplain fish species that show reduced dispersal capabilities. one‐lined pencilfish Nannostomus unifasciatus (family Lebiasinidae) a found in flooded forests the Rio Negro Floodplain (RNF) central Amazonia, Brazil. We used large number samples collected throughout distribution RNF and its headwaters DNA data from second intron S7 ribosomal protein to reconstruct...
Describing the role of plasmids and their contribution to exchange genetic material among bacteria is essential for understanding fields plasmid epidemiology, microbial ecology, commercial synthetic microbiology. Broad-host-range (BHR) are those that found not only in a single bacterial species, but members different taxonomic groups significant interest researchers many fields. We applied novel approach computationally identify new BHR plasmids, which we searched highly similar cognate...