A5089592866- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hormonal and reproductive studies
- Gynecological conditions and treatments
- Urological Disorders and Treatments
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Urologic and reproductive health conditions
- Adrenal Hormones and Disorders
- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Growth Hormone and Insulin-like Growth Factors
- Testicular diseases and treatments
- Ovarian function and disorders
- Molecular Biology Techniques and Applications
- Reproductive System and Pregnancy
- Paraquat toxicity studies and treatments
- Blood properties and coagulation
- Hemophilia Treatment and Research
- Menstrual Health and Disorders
- Hedgehog Signaling Pathway Studies
- Ecology and Conservation Studies
- Hernia repair and management
- Ectopic Pregnancy Diagnosis and Management
- Blood groups and transfusion
Peking Union Medical College Hospital
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Shandong University
2025
Qilu Hospital of Shandong University
2025
National Clinical Research
2022-2025
China Academy of Chinese Medical Sciences
2024
Academy of Medical Sciences
2022
Hung Yen University of Technology and Education
2005
California University of Pennsylvania
2004
University of Pennsylvania
2001
Summary Objective Phenotypic female disorders of sex development ( DSD ) patients with Y chromosome or Y‐derived sequence have an increased risk gonadal germ cell tumours GCT s). The objective the study was to evaluate tumour , summarize clinical characteristics s and propose management suggestions. Methods Medical records 292 diagnosed undergoing bilateral gonadectomy at Peking Union College Hospital from January 1996 March 2016 were retrospectively reviewed. Tumour histopathological types,...
Premature ovarian insufficiency (POI) refers to the decline of function before age 40. POI causes a reduction in or loss female fertility, accompanied by different degrees menopausal symptoms, which increases risk chronic diseases related early menopause and seriously affects patients' quality life health. It is conservatively estimated that at least one million prepubertal girls women reproductive China are iatrogenic caused radiotherapy chemotherapy every year. With development medical...
To investigate the therapeutic selection of abnormal uterine bleeding with ovulatory dysfunction (AUB-O) among Chinese women and analyze impact various factors. This was a cross-sectional study involving 3527 patients AUB-O diagnosed by local doctor between 14 55 years old. Questionnaire compiled according to treatment guidelines used collect demographic information. The were divided into juvenile group, reproductive senior group. results showed that irregular menstruation (37.6-46.3%),...
Heavy menstrual bleeding (HMB) has been shown to have a profound negative impact on women's quality of life and lead increases in health care costs; however, data HMB among Chinese population is still rather limited. The present study therefore aimed determine the current prevalence risk factors subjectively experienced community sample reproductive-age women, evaluate its effect daily life. We conducted questionnaire survey 2356 women aged 18–50 years living Beijing, China, from October...
The objective of this study was to examine risks for gonadal malignancy in a large sample adult female patients with disorders sex development (DSD). A retrospective-observational conducted from July 1992 March 2015 and 202 women DSD were enrolled. Tumor different types measured. We found that the patients' total gonadal-malignancy risk 18.3% (37/202). Tumors included gonadoblastoma (n = 11), seminoma 8), dysgerminoma 5), choriocarcinoma 1), sertoli cell tumors leydig 1). incidence complete...
ABSTRACT Active protein synthesis during early oogenesis requires accelerated transcription of ribosomal RNA genes (rDNAs). In response to this demand, rDNAs are amplified more than 1000-fold in Xenopus oogenesis. Here, we report evidence that rDNA is not mouse oocytes, but these cells may instead employ the zinc-finger basonuclin, a putative factor, enhance rRNA synthesis. This conclusion based on observations basonuclin localized nucleolus oocyte its growth phase, when Rrna highly active;...
Context: 17α-hydroxylase deficiency (17OHD) is a relatively rare disease, accounting for about 1% of congenital adrenal hyperplasia cases. The CYP17A1 gene mutation can lead to this disease. Human located on chromosome 10q24.3. It consists eight exons encoding 508 amino acids. To date, more than 50 mutations in and introns the have been reported cause complete or partial 17OHD. Objective: aim study was investigate types 17 Chinese patients, containing 11 six 17OHD patients. Setting: We...
Objective . In the process of care for disorders sex development (DSD), clinical decisions should focus on long-term quality life (QOL). We sought to investigate QOL patients with DSD in China. Design Case-control study was carried out. Patients. 90 participated study. Finally, 87 were analyzed including Turner’s syndrome (23), Noonan (2), androgen insensitivity (22), testicular regression congenital adrenal hyperplasia (16), and pure gonadal dysgenesis (22). Measurements The WHOQOL-BREF...
Objectives. To summarize the clinical characteristics of partial 17α-hydroxylase/17,20-lyase deficiency (17OHD) in 46,XX Chinese patients.
Abstract Tumorigenesis is frequently accompanied by enhanced rRNA transcription, but the signaling mechanisms responsible for such enhancement remain unclear. Here, we report evidence suggesting a novel link between deregulated Hedgehog and augmented transcription in cancer. Aberrant activation of pathway keratinocytes hallmark basal cell carcinoma (BCC), most common cancer light-skinned individuals. We show that Gli proteins, downstream effectors pathway, increase expression gene (rDNA)...
Diagnosis of female genital tuberculosis (FGTB) remains a challenge. The aim this study was to evaluate the diagnostic value T-SPOT.TB on peripheral blood mononuclear cells (PBMCs) for diagnosing FGTB in an area with high TB burden. Patients suspected were enrolled consecutively between August 2010 and 2015. PBMCs histopathology performed all patients. results evaluated against patients' final diagnosis which made based clinical manifestations, radiology, microbiological histopathological...
To highlight the challenges in diagnosing 46, XY disorder of sex development related to
Background. 17-Hydroxylase deficiency is a rare form of congenital adrenal hyperplasia caused by CYP17A1 gene mutations.Method. A 46,XY and 46,XX Chinese patients with 17-hydroxylase in family their four generations members were genotyped PCR-sequencing method.Results. Two CYP17 mutations identified from these patients. Among them, IVS1-1G > was novel splicing mutation which disrupted the acceptor signal exon 2 might create new after 1. The indel TAC329AA one-base deletion change at codon...
Context: Partial 17a-hydroxylase/17,20 lyase deficiency (17OHD) is a rare subtype of 17OHD caused by CYP17 gene mutations. Objective: Five Chinese 46,XX patients and one family with partial were genotyped. Patients: The five derived from different families them had another patient in family. diagnosis was established through clinical laboratory characteristics Peking Union Medical College Hospital, China, 2000 to 2010. Results: Seven mutations are identified these patients. Among them, R449C...
The objective of the study is to summarize clinical characteristics 33 patients' cohort (46,XX pure gonadal dysgenesis, 46,XX PGD), discuss management, and propose treatment suggestions. Patients' information, medical history, records were obtained. All patients closely followed up. At time diagnosis, presented 19.53 ± 3.60 years old, 165 6.49 cm height, breast development Tanner stage I, infantile female genitalia. High level follicle-stimulating hormone (87.41 21.50 mIU/mL) LH (27.10 8.47...
A historical account is presented of the development sex hormone treatment from its beginning at Peking Union Medical College to present-day generalization throughout China. The general theme this work has been test low-dose regimens. Notable successes include oral contraception and menopausal treatment. In support latter, we present a new clinical study effects low-dose, intermittent, patient-metered replacement therapy (HRT), which shows decreased symptoms, maintenance bone health height,...
Ovary enlargement is common in controlled ovarian stimulation, which could continue several months during a successful pregnancy. However, persistent megalocystic ovaries 3 years after hyperstimulation syndrome (OHSS) were rare. Here we will present you the case and treatment as well discuss probable etiology. A 34-year-old woman with polycystic (PCOS) history of infertility presented to Department Obstetrics Gynecology at Peking Union Medical College Hospital abdominal pain persistently...
Introduction: Disorders of sex development (DSD) is a congenital condition in which the chromosomal, gonadal or genital atypical. Majority patients present clinical characteristics primary amenorrhea, absent secondary characters, and abnormal hormone level. A female appearance patient with amenorrhea 46 XY karyotype seems to be solid evidences diagnose Y-chromosome-related DSD diseases, while it not necessarily accurate diagnosis. We report case an 18-year-old girl misdiagnosed as DSD....