A5101702047- Mesenchymal stem cell research
- Breast Cancer Treatment Studies
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Anesthesia and Neurotoxicity Research
- Water Quality Monitoring Technologies
- Pluripotent Stem Cells Research
- Underwater Vehicles and Communication Systems
- Electrospun Nanofibers in Biomedical Applications
- HER2/EGFR in Cancer Research
- Pancreatic function and diabetes
- Bone Metabolism and Diseases
- Genetic Syndromes and Imprinting
- Heme Oxygenase-1 and Carbon Monoxide
- Neurogenesis and neuroplasticity mechanisms
- Digital Image Processing Techniques
- Atherosclerosis and Cardiovascular Diseases
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Advanced Neuroimaging Techniques and Applications
- Lipid metabolism and disorders
- Pregnancy-related medical research
- Cancer-related molecular mechanisms research
- Fish Ecology and Management Studies
West China Hospital of Sichuan University
2024
Nanjing University
2024
Sichuan University
2024
Chinese PLA General Hospital
2019-2023
Johns Hopkins University
2016-2022
Johns Hopkins Medicine
2016-2022
National Taiwan Ocean University
2021-2022
R.O.C Military Academy
2021
Huashan Hospital
2019
Fudan University
2019
The ocean resources have been rapidly depleted in the recent decade, and complementary role of aquaculture to food security has become more critical than ever before. Water quality is one key factors determining success real-time water monitoring an important process for aquaculture. This paper proposes a low-cost easy-to-build artificial intelligence (AI) buoy system that autonomously measures related data instantly forwards them via wireless channels shore server. Furthermore, provide...
The treatment of diabetic wounds is a major challenge faced by the medical system, and there growing interest in developing innovative therapies to accelerate wound healing. Regenerative medicine with cells has shown promising potential skin repair, regenerative properties primarily attributed paracrine effects secreted products, including exosomes. Compared cell-based approaches, using exosomes as cell-free therapy for chronic several advantages. Exosomes can regulate intercellular...
Significance Sensory nerves innervate bone and are required for normal skeletal development, but the molecular mechanisms through which exert these essential functions have remained obscure. Here, we validate a spatial transcriptomics platform, allowed us to map changes in landscape across developing cranium of mice sensory nerve innervation is genetically blocked. We show that sensory, nerve-derived signals, including follistatin-like 1, coordinate cranial patterning by regulating...
The Varikon box, a 3-dimensional variant of the 15-puzzle, is focus this investigation. goal to investigate three questions: Whether swapping positions two its blocks affect solvability, number distinct configurations puzzle, and least steps needed for solving 15-puzzle. First, we introduced our investigation with same questions, yet specifically using permutation parity testify one’s then finding pattern vice versa that possible 15-puzzle configurations, all it mirrored onto study Boxes...
We validated an 18-gene classifier (GC) initially developed to predict local/regional recurrence after mastectomy in estimating distant metastasis risk. The scoring algorithm defines scores as: <21, low risk; ≥21, high Six hundred eighty-three patients with primary operable breast cancer and fresh frozen tumor tissues available were included. outcome was the 5-year probability of freedom from (DMFP). Two external datasets used test predictive accuracy 18-GC. rates DMFP for classified as...
ABSTRACT Synovial joint development begins with the formation of interzone, a region condensed mesenchymal cells at site prospective joint. Recently, lineage-tracing strategies have revealed that Gdf5-lineage native to and from outside interzone contribute most, if not all, major components. However, there is limited knowledge specific transcriptional signaling programs regulate fate diversification synovial constituents. To address this, we performed single cell RNA-Seq analysis 7329...
Abstract Vascular endothelial cell (EC) plasticity plays a critical role in the progression of atherosclerosis by giving rise to mesenchymal phenotypes plaque lesion. Despite evidence for arterial stiffening as major contributor atherosclerosis, complex interplay among atherogenic stimuli vivo has hindered attempts determine effects extracellular matrix (ECM) stiffness on endothelial‐mesenchymal transition (EndMT). To study regulatory ECM EndMT, an vitro model is developed which human...
Heterotopic ossification (HO) is a form of pathological cell-fate change mesenchymal stem/precursor cells (MSCs) that occurs following traumatic injury, limiting range motion in extremities and causing pain. MSCs have been shown to differentiate bone; however, their lineage aberrant processes after trauma are not well understood. Utilizing well-established mouse HO model inducible lineage-tracing (Hoxa11-CreERT2;ROSA26-LSL-TdTomato), we found Hoxa11-lineage represent progenitors specifically...
A non-viral nanoparticle-based transfection method delivers Sox2 or Olig2 into primary human astrocytes to convert the neurons and oligodendrocyte progenitors, respectively, providing a highly translatable approach for engineering repair injured central nervous tissues.
// Tzu-Ting Huang 1 , Nicolas Pennarun Yu-Hao Cheng 2 Cheng-Fang Horng Jason Lei 3 and Skye Hung-Chun 1, 4 Department of Medical Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan Medicine, Cathy General Hospital, Product Development, Amwise Diagnostics Pte Ltd, Radiation Oncology, Correspondence to: Cheng, email: Skye@kfsyscc.org Keywords: breast cancer; distant recurrence prediction; microarray; gene expression profiling; chemotherapy Received: November 16, 2017 Accepted:...
Aberrant transforming growth factor β (TGFβ) activation is detrimental to both nucleus pulposus (NP) cells and cartilage endplates (CEPs), which can lead intervertebral disc degeneration (IDD). Ligustrazine (LIG) reduces the expression of inflammatory factors TGFβ1 in hypertrophic CEP prevent IDD. In this study, we investigate effects LIG on NP TGFβ signaling.LIG was injected lumbar spinal instability (LSI) mouse model. The effect evaluated by (IVD) score LSI activated examined using...
The mechanisms by which bone marrow stromal cells (BMSCs) maintain multilineage potency in vitro remain elusive. To identify the transcriptional regulatory circuits that contribute to BMSC multipotency, we performed paired single-nucleus multiomics of expansion freshly isolated BMSCs and undergoing tri-lineage differentiation. By computationally reconstructing programs associated with initial stages differentiation early expansion, identified TEAD family transcription factors, is inhibited...
Since ocean resources are rapidly depleted in the recent decade, complementary role of aquaculture has become more important than before. Further, determining quality and success aquaculture, key factor is water. Hence, monitoring water a vital work for aquaculture. To this end, paper we propose low-cost easy-to-build artificial intelligence (AI) buoy system. The proposed system autonomously measures relevant data then instantly forwards them via wireless channel to shore server. In...
Objective In this work, we propose a novel method for constructing whole-brain spatio-temporal multilayer functional connectivity networks (FCNs) and four innovative rich-club metrics. Methods Spatio-temporal FCNs achieve high-order representation of the dynamic characteristics brain by combining sliding time window with graph theory hypergraph theory. The proposed scales are based on changes in node identity, providing parameterized description topological from both temporal spatial...
Intermittent Fasting (IF), a dietary modification through time-restricted feeding, has gained significant attention in the past few years owing to its advantages metabolic health and weight management. Available evidence suggests that IF can improve insulin sensitivity; lower levels of blood glucose fat; prevent body fat accumulation; reduce risk obesity-related chronic disease by mitigating oxidative damage affecting activity antioxidant enzymes. However, number gaps knowledge remain...
SUMMARY Synovial joint development begins with the formation of interzone, a region condensed mesenchymal cells at site prospective joint. Recently, lineage tracing strategies have revealed that Gdf5-lineage native to and from outside interzone contribute most, if not all, major components. However, there is limited knowledge specific transcriptional signaling programs regulate fate diversification synovial constituents. To address this, we performed single cell RNA-Seq analysis 6,202...
Background Multipotent bone marrow stromal cells (BMSCs) are adult stem that form functional osteoblasts and play a critical role in remodeling. During aging, an increase loss reduction structural integrity lead to osteoporosis result increased risk of fracture. We examined age-dependent histological changes murine vertebrae uncovered begins as early the age 1 mo. Aim To identify alterations transcriptomic dynamics BMSCs during loss. Methods collected from mice at middle ages compared their...
患者女性，20岁，糖尿病伴多囊卵巢综合征病史6年。发病初期使用胰岛素皮下注射治疗效果佳，后停用胰岛素使用口服药治疗。近1年因血糖异常升高再次启用胰岛素皮下注射治疗，但超大剂量胰岛素皮下注射血糖控制不佳；实验室检查示空腹胰岛素轻度升高，未发现拮抗胰岛素激素水平增高的内分泌疾病，基因检测未见异常突变；静脉胰岛素输注可将血糖控制达标。最终诊断为2型糖尿病合并皮下胰岛素抵抗综合征。使用二甲双胍、恩格列净联合肌肉注射胰岛素，患者血糖控制平稳。.
Objective: To investigate the effect and regulation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) on islets function NOD-like receptor family, pyrin domain containing 3 (NLRP3) autophagy in type 2 diabetic mellitus (T2DM) mice. Methods: Experimental study. Twenty, 8-week-old, male C57BL/6J mice were selected divided into a normal control group (n=5) high-fat feeding modeling (n=15). The model T2DM was established by combined with intraperitoneal injection low-dose...