A5030154551- Cardiac Imaging and Diagnostics
- Cardiac tumors and thrombi
- Hemodynamic Monitoring and Therapy
- Vestibular and auditory disorders
- Obstructive Sleep Apnea Research
- Renal and Vascular Pathologies
- Aortic Thrombus and Embolism
- Cerebrovascular and Carotid Artery Diseases
- Ear Surgery and Otitis Media
- Cardiac electrophysiology and arrhythmias
- Medical Imaging Techniques and Applications
- ECG Monitoring and Analysis
- Neurofibromatosis and Schwannoma Cases
- Sesquiterpenes and Asteraceae Studies
- Lysosomal Storage Disorders Research
- Inflammatory Bowel Disease
- Circadian rhythm and melatonin
- Ear and Head Tumors
- Sleep and Wakefulness Research
- Bone health and treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Respiratory Support and Mechanisms
- Protein Degradation and Inhibitors
- Cerebral Venous Sinus Thrombosis
- Chronic Disease Management Strategies
Hospitais da Universidade de Coimbra
2017-2023
University of Coimbra
2007-2022
Research Center for Natural Resources, Environment and Society
2016
BackgroundObstructive Sleep Apnea (OSA) is a highly prevalent and underdiagnosed sleep disorder. Recent studies suggest that OSA might disrupt the biological clock, potentially causing or worsening OSA-associated comorbidities. However, effect of treatment on clock disruption not fully understood.MethodsThe impact short- (four months) long-term (two years) treatment, with Continuous Positive Airway Pressure (CPAP), was investigated at four time points within 24 h, in patients relative to...
The survival of multiple myeloma patients has improved very significantly over the last decade. Still median overall is inferior to 5 years. A small proportion survive longer than 10 In this paper we discuss four cases illustrating nonhomogeneous clinical presentation and evolution subset patients. Surprisingly, these long survivors do not always have deep responses some require frequent treatments, which include autologous stem cell transplantation novel drugs. authors several aspects...
A 30-year-old man, forestry worker, with no medical history, presented acutely pruritic erythematous streaks and bullae (figure 1) in linear configuration on his arms. On the previous day he had pruned branches from a fig tree carried them forearms wearing sleeveless shirt. Symptoms gradually resolved over 4 weeks of topical treatment clobetasol propionate 0.05% cream 2). Figure 1 Bullae irregular pigmented lesions both …
Abstract Aims In Portugal, in the last 5 years, no study has published recent data regarding outcomes of patients with acute decompensated heart failure (ADHF). We aimed to determine characteristics and a large contemporaneous Portuguese cohort ADHF admitted our emergency department (ED). Methods results conducted retrospective, all 1024 ED discharge diagnosis from November 2016 December 2017. Baseline clinical {in‐hospital, 30 day, follow‐up all‐cause mortality, readmissions; median...
Treatment-induced neuropathy of diabetes (TIND) is an acute, painful and rare complication intensive glycaemic control in diabetes. We present a case 32-year-old man with sudden onset severe lower limb pain. It worsened progressively was refractory to analgesic muscle relaxant therapies. became so that the patient impossible stand, causing marked impact on his daily life. He had history type 1 diabetes, diagnosed 3 years ago, episode deep vein thrombosis left leg, 4 ago. While completing...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Background Neurofibromatosis type 1 (NF1) is a common genetic disorder of phenotypic variability with age-dependent penetrance. This study describes the diagnosis, clinical characterization, management, and outcomes large patient cohort plexiform neurofibroma (PN) treated selumetinib in real-world setting. Methods single-center observational consecutively enrolled patients NF1-PN from April 2018 to 2023. Data on features, tumor types locations, results tests were recorded at...
A previously healthy 45-year-old Portuguese woman presented to the emergency department in February 2020 with a sudden onset of pain fifth finger her right hand. Subsequently, bruising appeared not only on that but also thumb and thenar eminence ([figure 1][1]). This
Pancreatic cancer is the tumour related to higher rates of depression. Several papers have validated association between pancreatic and It was noticed that in some cases psychiatric symptoms precede somatic ones. We present a case progressive incapacitating diffuse abdominal pain, initially attributed psychosomatic disorder. This hindered timely correct diagnosis leading poor outcome. A adenocarcinoma an unresectable stage confirmed by histopathology. The patient underwent chemotherapy.
Abstract Distinguishing airway vascular tumors from malformations can be challenging. Failure to treat a suspected hemangioma with beta‐blocker and systemic corticosteroid should raise suspicion of possible malformation.
Aim: To identify factors of prognosis vestibular rehabilitation (VR) in patients with chronic unilateral hypofunction (CUVH). Study Design: Retrospective study the charts diagnosed CUVH, who underwent VR. Material and methods: We recorded epidemiological clinical data, results posturography dizziness handicap inventory (DHI) tests, before after VR, investigated a relationship between these data test results. Results: registered 71 patients, most 2 to 3 comorbidities. found significant...
Cysticercosis is a tissue infection caused by larval cysts of the tapeworm Taenia solium that acquired from faecal-oral transmission (ingestion eggs present in contaminated food or water) and one major causes epilepsy areas where T. endemic.[1 2][1] Migration
In Pompe disease (PD), sleep disordered breathing (SDB) appears as the first sign of respiratory muscle dysfunction, with hypoventilation that worsens during REM sleep. Sleep apnea has also been reported in late-onset disease. Our main aim was to study polysomnographic findings patients PD. We included 6 patients, 4 childen classic infantile-onset and 2 adults All but one already under enzyme replacement therapy. Polysomnography non-invasive ventilation (NIV) performed those on NIV, children...
Abstract Background Intestinal ultrasound (IUS) is a non-invasive monitoring tool increasingly being used to assess response therapy in Crohn’s disease (CD). Herein we describe the longitudinal evolution of IUS parameters, and its correlation with clinical, laboratorial endoscopic parameters during first year infliximab (IFX) therapy. Methods Prospective multicentre cohort study patients active CD starting IFX. Harvey-Bradshaw index (HBI), C-reactive protein (CRP), fecal calprotectin (FC)...
<h3>Introduction</h3> In our daily practice we have noticed that, particularly when there is a predominance of respiratory effort, AutoCPAP cannot always control patients' symptoms and they appear to tolerate better fixed CPAP pressure. However, in the literature, no evidence sustaining this observation. So designed prospective study evaluate best treatment modality for these patients. <h3>Methods</h3> We included patients with Respiratory Disturbance Index (RDI) > 15events/h...
Background: 2D speckle tracking-derived strain measurement is an accepted echocardiographic method for the assessment of global left ventricular function.Standardization efforts brought us a clearer definition layer-specific measurements, but companies do still use different layers their routinely reported and segmental values.Little known about potential advantages or disadvantages clinical layers.Based on data second inter-vendor comparison study, we therefore investigate in this study...