A5100443110- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Scheduling and Optimization Algorithms
- RNA Interference and Gene Delivery
- Operations Management Techniques
- Manufacturing Process and Optimization
- Supply Chain and Inventory Management
- Epigenetics and DNA Methylation
- Lipid metabolism and biosynthesis
- Genetic Associations and Epidemiology
- Collaboration in agile enterprises
- Acute Myeloid Leukemia Research
- Trace Elements in Health
- Economic theories and models
- Digital Innovation in Industries
- Helicobacter pylori-related gastroenterology studies
- RNA regulation and disease
- Immune Cell Function and Interaction
- S100 Proteins and Annexins
- Caveolin-1 and cellular processes
- Soybean genetics and cultivation
- Business Strategy and Innovation
- RNA Research and Splicing
Guangdong Academy of Agricultural Sciences
2023
Ministry of Agriculture and Rural Affairs
2023
Jiangsu Cancer Hospital
2021
Nanjing Medical University
2021
State Key Laboratory of Biotherapy
2014-2021
Sichuan University
2014-2021
Army Medical University
2015-2020
Southwest Hospital
2013-2020
Weifang People's Hospital
2020
Nanjing Drum Tower Hospital
2012-2019
Reprogramming energy metabolism has been an emerging hallmark of cancer cells. MicroRNAs play important roles in glucose metabolism. The targets microRNA-26a (miR-26a) were predicted by bioinformatics tools. efficacy miR-26a binding the 3′-untranslated region (UTR) pyruvate dehydrogenase protein X component (PDHX) mRNA was evaluated using a dual-luciferase reporter assay. PDHX expression at and level several colon cell lines quantified with real-time PCR Western blot analysis respectively....
Abstract Background The emerging concept is that microRNAs (miRNAs) play a central role in controlling stem cell self-renewal and fate determination by regulating the expression of regulators. miR-125b , one neuronal miRNAs, recently was found to be necessary for neural differentiation stem/progenitor cells (NS/PCs). However, other specific biological NS/PCs little known. We used rat as model system study governing behavior NS/PCs. Results report here transfection exogenous inhibited...
We previously reported the inhibitory effects of microRNA-26a (miR-26a) on conversion pyruvate to acetyl coenzyme A in glucose metabolism by directly targeting dehydrogenase protein X component colorectal cancer (CRC) cells (Chen B et al., BMC Cancer 2014). Here, using microRNA situ hybridization, we confirmed that miR-26a levels were elevated 77 human CRC tissue samples and further investigated key miR-26a-mediated metabolic regulation elements signaling pathways through quantitative...
Background/Aims: Pulmonary microvascular endothelial cell (PMVEC) proliferation and angiogenesis contribute to the development of hepatopulmonary syndrome (HPS). MicroRNA-199a-5p (miR-199a-5p) has emerged as a potent regulator angiogenesis, its expression levels significantly decrease in serum patients with hepatopathy. However, it not been reported about whether miR-199a-5p might control PMVEC proliferation. Here, we described governing HPS. Methods: PMVECs were treated rat from common bile...
Zinc transporter 8 (ZnT8) is exclusively expressed in the pancreatic islet and essential for insulin crystallization, hexamerization secretion. Tumor necrosis factor α‑induced protein‑3 (TNFAIP3) a zinc finger protein that serves major role negative feedback regulation of NF‑κB signaling response to multiple stimuli, central regulator immunopathology. Although TNFAIP3 diabetes has been extensively studied, its effect on ZnT8 not fully elucidated. The present study aimed verify whether...
Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer. Studies have found that miR-1293 related to survival LUAD patients. Unfortunately, its role in remains not fully clarified.miR-1293 expression and association with patients' clinical characteristics were analyzed TCGA database. Also, was detected cell lines. Cell viability, migration, invasion MMP2 MMP9 measured cells following transfection mimic or antagomir. Phosphoglucomutase (PGM) 5 identified be negatively...
To investigate the expression of microRNA-29c (miR-29c) in glioma and its effects on cell proliferation apoptosis.A retrospective analysis was performed 76 patients People's Hospital Weifang, Shandong, China from May 2013 to June 2017 (experimental group) 63 healthy subjects same period (control group). qRT-PCR used detect miR-29c expression. Changes serum level correlation with degree tumor differentiation pathological type were observed. Cells grouped before transfection into blank group...
In order to solve decision problem for maximum production capacity of different products under output demand uncertainty, the non-cooperative game theory was introduced describe competition relationship between various shared manufacturing resources. Firstly line model is built based on complex network, which resources aggregated vertices and process relationships described as directed edges vertices. Secondly evaluated through analysis running vertices, available duty load were defined....
Objective To evaluate the changes in expression of annexin A2 (ANXA2) lung tissues rats with hepato-pulmonary syndrome.Methods Healthy 3-4-month-old Sprague-Dawley both sexes,weighing 220-250 g,were randomly divided into 3 groups:control group (group C,n =10),sham operation S,n =10) and hepatopulmonary syndrome HPS,n =20).The were anesthetized intraperitoneal 3％ pentobarbital sodium 0.1 ml/100 g.Hepatopulmonary was produced by chronic ligation common bile duct.After 5 weeks,the sacrificed...
In order to reduce the impact of data noise quality control and make monitor results more precise in manufacturing process, method statistical process based on Kalman filter was proposed. this method, model built exponentially weighted moving average put forward. While monitoring first technology used smooth noise, then charts were by quality. Finally, performance tranditional compared. The result illustrates feasibility validity proposed method.