Emma C. E. Wassenaar
A5035560467- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Management of metastatic bone disease
- Genetic factors in colorectal cancer
- Hernia repair and management
- Renal cell carcinoma treatment
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Intestinal and Peritoneal Adhesions
- Anesthesia and Pain Management
- Luminescence Properties of Advanced Materials
- Diverticular Disease and Complications
- Lymphatic System and Diseases
- Gene expression and cancer classification
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Radiopharmaceutical Chemistry and Applications
- Protease and Inhibitor Mechanisms
- Streptococcal Infections and Treatments
St. Antonius Ziekenhuis
2018-2025
University Medical Center Utrecht
2019-2024
University of Amsterdam
2023
Amsterdam University Medical Centers
2023
Cancer Center Amsterdam
2023
Utrecht University
2022
Dutch Colorectal Cancer Group
2021
The Netherlands Cancer Institute
2021
Massachusetts General Hospital
2020
Harvard University
2020
Abstract Background Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in Netherlands. This study investigates whether addition of perioperative systemic therapy to CRS-HIPEC improves oncological outcomes. Methods open-label, parallel-group, phase II-III, randomised, superiority performed nine Dutch tertiary referral centres. Eligible patients are adults who have a good performance status,...
Patients with peritoneal metastases from colorectal cancer have a poor prognosis. If the intraperitoneal tumour load is limited, patients may be eligible for cytoreductive surgery followed by hyperthermic chemotherapy (HIPEC). This treatment has improved overall survival, but recurrence rates are high. The aim of this study was to create preclinical platform development more effective strategies.Using organoid technology, five cultures were generated malignant ascites and resected...
Peritoneal metastases (PM) in colorectal cancer (CRC) are associated with therapy resistance and poor survival. Oxaliplatin monotherapy is widely applied the intraperitoneal treatment of PM, but fails to yield clinical benefit. We aimed identify mechanism(s) underlying PM oxaliplatin develop strategies overcoming such resistance.We generated a biobank consisting 35 primary tumour regions 59 paired from 12 patients. All samples were analysed by RNA sequencing. also series PM-derived organoid...
<h3>Importance</h3> To date, no randomized clinical trials have investigated perioperative systemic therapy relative to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) alone for resectable colorectal peritoneal metastases (CPM). <h3>Objective</h3> assess the feasibility safety of in patients with CPM response neoadjuvant treatment. <h3>Design, Setting, Participants</h3> An open-label, parallel-group phase 2 trial all 9 Dutch tertiary centers surgical treatment...
Abstract Background The role of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer is unknown. This non-randomized dose-finding phase I–II study was designed to assess the safety and feasibility HIPEC, following systemic chemotherapy, patients limited peritoneal dissemination. maximum tolerated dose normothermic docetaxel combination a fixed oxaliplatin also explored. Methods Patients resectable cT3–cT4a adenocarcinoma metastases and/or...
Abstract Background In colorectal cancer (CRC), the consensus molecular subtype 4 (CMS4) is associated with therapy resistance and poor prognosis. Clinical diagnosis of CMS4 hampered by locoregional temporal variables influencing CMS classification. Diagnostic tools that comprehensively detect are therefore urgently needed. Methods To identify targets for imaging, RNA sequencing data 3232 primary CRC patients were explored. Heterogeneity marker expression in relation to status was assessed...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. Whether adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) might prevent peritoneal metastases after...
Abstract Tumor‐derived cell‐free DNA (cfDNA) is an emerging biomarker for guiding the personalized treatment of patients with metastatic colorectal cancer (CRC). While CRC liver metastases (CRC‐LM) have relatively high levels plasma cfDNA, little known about peritoneal (CRC‐PM). This study evaluated presence tumor‐derived cfDNA in and fluid (i.e. ascites or washing) 20 isolated CRC‐PM 100 CRC‐LM. Among tumor tissue KRAS/BRAF mutation carriers, was detected by droplet digital polymerase chain...
Introduction Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy with oxaliplatin (ePIPAC-OX) is offered as a palliative treatment option for patients isolated unresectable colorectal peritoneal metastases (PM) in several centres worldwide. However, little known about its feasibility, safety, tolerability, efficacy, costs and pharmacokinetics this setting. This study aims to explore these parameters PM who receive repetitive ePIPAC-OX monotherapy. Methods analysis...
Abstract Introduction The PERISCOPE I (Treatment of PERItoneal dissemination in Stomach Cancer patients with cytOreductive surgery and hyPErthermic intraperitoneal chemotherapy) study was conducted to investigate the safety feasibility hyperthermic chemotherapy (HIPEC) gastric cancer limited peritoneal dissemination. In this study, tumor characteristics clinical outcome treated trial were investigated. Methods Patients who had undergone full protocol selected; that is, preoperative systemic...
Patients with colon cancer liver metastases may be cured surgery, but the presence of additional lung often precludes curative treatment. Little is known about processes driving metastasis. This study aimed to elucidate mechanisms governing vs metastasis formation.Patient-derived organoid (PDO) cultures were established from tumors distinct patterns Mouse models recapitulating metastatic organotropism created by implanting PDOs into cecum wall. Optical barcoding was applied trace origin and...
Background Necrotizing fasciitis is a potentially lethal condition for which early and adequate treatment with surgical debridement broad-spectrum intravenous antibiotics are essential survival. It hypothesized that Group A Streptococcus (GAS) necrotizing causes exhaustion of the immune system, making these patients more susceptible late secondary infections. Methods retrospective study was conducted all between 2002 2016. Patients based on macroscopic findings, positive Gram staining,...
Whether metastasis in humans can be accomplished by most primary tumor cells or requires the evolution of a specialized trait remains an open question. To evaluate whether metastases are founded non-random subsets lineages extensive, difficult-to-implement sampling. We have realized unusually dense multi-region sampling scheme cohort 26 colorectal cancer patients with peritoneal metastases, reconstructing evolutionary history on average 28.8 tissue samples per patient microsatellite-based...
Introduction Despite its increasing use, first-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy oxaliplatin (ePIPAC-OX), hereinafter referred to as bidirectional therapy, has never been prospectively investigated in patients colorectal peritoneal metastases (CPM). As a first step address this evidence gap, the present study aims assess safety, feasibility, antitumour activity, patient-reported outcomes, costs and pharmacokinetics...
Abstract Background CRC-PIPAC prospectively assessed repetitive oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (PIPAC-OX) as a palliative monotherapy (i.e., without concomitant systemic therapy in between subsequent procedures) for unresectable colorectal peritoneal metastases (CPM). The present study explored patient-reported outcomes (PROs) during trial treatment. Methods In this single-arm phase 2 two tertiary centers, patients with isolated CPM received 6-weekly...
Oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (PIPAC-OX) is an emerging palliative treatment for patients with unresectable colorectal peritoneal metastases. Previously, our study group reported that experienced abdominal pain several weeks after PIPAC-OX. However, it unknown how this compares to regular cancer surgery. To provide some perspective, compared the presence of PIPAC-OX primary tumor Patient scores (EORTC QLQ-CR-29), from two prospective, Dutch cohorts were...