A5056671609- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Barrier Structure and Function Studies
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Orthopaedic implants and arthroplasty
- SARS-CoV-2 and COVID-19 Research
- Occupational and environmental lung diseases
- Effects of Radiation Exposure
- Neuroendocrine Tumor Research Advances
- S100 Proteins and Annexins
- COVID-19 and healthcare impacts
- Nanoparticle-Based Drug Delivery
- Renin-Angiotensin System Studies
- Lanthanide and Transition Metal Complexes
Peking University Cancer Hospital
2014-2024
Peking University
2012-2024
National Medical Products Administration
2021-2024
Dalian Medical University
2023-2024
First Affiliated Hospital of Dalian Medical University
2023-2024
First Affiliated Hospital of Zhengzhou University
2024
Rapid progress has been made to identify and study the causative agent leading coronavirus disease 2019 (COVID-19) but many questions including who is most susceptible what determines severity remain unanswered. Angiotensin-converting enzyme 2 (ACE2) a key factor in infection process of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In this study, molecularly specific positron emission tomography imaging agents for targeting ACE2 are first developed, these novel evaluated...
Claudin 18.2 (CLDN18.2) is a new potential target for cancer therapy, especially advanced gastric (AGC). A molecular targeting probe of importance patient stratification and therapeutic guidance. Here, we explored an antibody-dependent imaging strategy specific detection surgery guidance based on CLDN18.2-specific antibody, 5C9. Two probes, 124I-5C9 Cy5.5-5C9, were synthesized. The specificity to CLDN18.2 being evidenced in the cellular experiments with control, diagnostic utility was...
Copper-64 is a useful radioisotope for positron emission tomography (PET). Due to the wide range of applications, demand 64Cu with low metallic impurities increasing. Here we report simple method efficient production high specific activity using cyclotron biomedical application. We designed new equipment based on plating enriched 64Ni as target, and used automated ion exchange chromatography purify copper-64 efficiently after irradiation dissolution target in good radiochemical chemical...
Somatostatin receptor subtype 2 (SSTR2) is highly expressed in pulmonary neuroendocrine tumors, which account for approximately 25% of all lung cancers including small-cell cancer (SCLC). It possible to establish SCLC-specific imaging agents multimodal obtain tumor integrity information. Herein, we constructed novel multifunctional organic melanin nanoparticles (MNPs) as a carrier and surface-loaded somatostatin analog octreotide produce human cancer-targeted nanoprobe OCT-PEG-MNPs. MNPs...
Programmed death ligand 1 (PDL1) is a specific molecular target for the diagnosis and immunotherapy of solid tumors. PET imaging can be used noninvasive assessments PDL1 expression in tumors to aid therapy selection. The most frequently reported small-molecule radiotracer limited by low specificity, short residence time, singular functionality. Here, we combined biocompatible melanin nanoprobe with PDL1-binding peptide WL12 construct novel radiotracer, 124I-WPMN, enhance targeting....
Carbonic anhydrase IX (CAIX), a zinc metal transmembrane protein, is highly expressed in 95% of clear cell renal carcinomas (ccRCCs). A positron emission tomography (PET) probe designed to target CAIX nuclear medicine imaging technology can achieve precise positioning, noninvasive, and be used monitor expression lesions real time. In this study, we constructed novel acetazolamide dual-targeted small-molecule [
Although anti-programmed cell death molecule-1 (PD-1)/PD-1 ligand therapy has achieved remarkable success in oncology field, the low response rate and lack of accurate prognostic biomarker identifying benefiting patients remain unresolved challenges. This study developed a PD-1 targeting radiotracer 124I-labeled toripalimab (124I-JS001) for clinical PET imaging evaluated its biodistribution, safety, dosimetry human.Patients with melanoma or urologic cancer confirmed by pathology were...
Abstract Background Adoptive T cell transfer-based immunotherapy yields unsatisfactory results in the treatment of solid tumors, partially owing to limited tumor infiltration and immunosuppressive microenvironment tumors. Therefore, strategies for noninvasive tracking adoptive cells are critical monitoring guiding development novel combination therapies. Methods We developed a radiolabeling method cytotoxic lymphocytes (CTLs) that comprises metabolically labeling surface glycans with...
Angiotensin-converting enzyme 2 (ACE2) is the main molecular target for coronavirus SARS-CoV-2 to enter cells. Molecularly specific tracers that bind ACE2 with high affinity can be used determine tissue distribution of this important receptor, noninvasively. A novel targeting PET imaging probe, [
In recent years, PD-L1 has been primarily utilized as an immune checkpoint marker in cancer immunotherapy. However, due to tumor heterogeneity, the response rate such therapies often falls short of expectations. addition its role immunotherapy, serves a specific target on surface cells for targeted diagnostic and therapeutic interventions. There is absence fully developed PD-L1-targeted probe clinical use, which constrains exploration exploitation this target.
Mesothelin (MSLN) is a molecular biomarker of many types solid tumors, such as mesothelioma, pancreatic cancer, and colon cancer. Owing to the significant difference in expression between cancer cells normal cells, mesothelin has been widely used key target immunotherapy. In this study, we iodine isotope (nat/124/125I)-labeled antibodies noninvasively detect MSLN mice with LS174T The 124I-labeled antibody showed high radiochemical purity (RCP, >99%) specific activity (20.8–67.8 GBq/μmol)...
Prostate-specific membrane antigen (PSMA) is an attractive target for the diagnosis and therapy of prostate cancer as it specifically overexpressed in cells. Improving circulation radioligands blood considered effective strategy that can improve tumor burden, which benefits detection small lesions improves effect PSMA radioligand (PRLT). In this study, we introduced maleimidopropionic acid (MPA) to a PSMA-targeted tracer developed Al 18 F-PSMA-CM, targets human serum albumin (HSA) binding...
The next‐generation positron zirconium‐89 ( 89 Zr, T 1/2 = 3.27 days) is a novel nuclide for immunological emission tomography because of its favorite longer half‐life. aim this work to develop optimized methods routine production and purification Zr through Monte Carlo (MC) simulation laboratory experiments. Y(p,n) reaction was used production. Optimized thicknesses Al degrader (0.11 cm) Y foil (0.064 were simulated MC method. (15.0–40.7 mCi) with an average rate 0.92 ± 0.12 mCi/μA·h...
Abstract Background The aim of the study was to explore therapeutic effect ultrasound targeted destruction schisandrin A contrast microbubbles on liver cancer and its related mechanism. Materials methods Span-PEG loaded with were prepared using Span60, NaCl, PEG-1500, A. loading rate in composite determined by ultraviolet spectrophotometry method. Walker-256 cell survival 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay. content cells high performance liquid...
In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation wound healing and flow cytometry were used to detect cell apoptosis cycle. It was found that schisandrin may have significant anti-tumor effects by inhibiting TGF-β/Smad signaling pathway. addition, vivo immunohistochemistry observe the expression of HIF-1α, VEGF VEGFR-2 tumor tissues. could significantly improve immunosuppression induced 5-Fu enhance antitumor effect 5-Fu. The mechanism be related...
Background Liver cancer is a common threat to human health. Schizandrin A (SA) has certain therapeutic effect on liver cancer, but its related mechanism of action not clear. Elucidating this great significance for the development drugs target cancer. Objective The objective study and SA Methods potential targets in treatment were screened based network pharmacology, core further by protein interaction. Kyoto Encyclopedia Genes Genomes (KEGG) analysis was performed find key pathways action....