A5019412738- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- Mass Spectrometry Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- bioluminescence and chemiluminescence research
- Breast Cancer Treatment Studies
- Cutaneous Melanoma Detection and Management
- HER2/EGFR in Cancer Research
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Cardiac Structural Anomalies and Repair
- Biofuel production and bioconversion
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Protease and Inhibitor Mechanisms
- Chemical Synthesis and Analysis
National Medical Products Administration
2021-2025
Peking University Cancer Hospital
2015-2024
Peking University
2012-2024
The overexpression of somatostatin receptor type 2 (SSTR2) is a unique characteristic gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), which establishes the basis for both diagnosis and therapy. SSTR status can be evaluated by immunohistochemical staining (IHC) 68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) imaging. This study attempted to determine relationship between IHC PET/CT imaging explore optimal cutoff value reading.A total 100 GEP-NENs with...
Objectives 68 Ga-P15-041 ( Ga-HBED-CC-BP) is a novel bone-seeking PET radiotracer, which can be readily prepared by using simple kit formulation and an in-house Ga/ Ge generator. The aim of this study to assess the potential human application for clinical PET/CT imaging compare its efficacy detect bone metastases different cancers with 99 mTc-MDP whole-body scintigraphy (WBBS). Methods Initial kinetic Patlak analysis parametric maps were performed in five histopathologically proven cancer...
This study aimed to assess the efficacy of dual-tracer [68Ga-DOTA-somatostatin receptor analogs (SSAs) and 18F-fluorodeoxyglucose (FDG)] positron emission tomography/computed tomography (PET/CT) imaging for detecting bone metastases (BMs) in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).We retrospectively enrolled 74 GEP-NEN BMs from two centers, who underwent PET/CT January 2014 March 2021. We compared analyzed effectiveness dual techniques on BMs, based 18F-FDG...
Prostate-specific membrane antigen (PSMA) is an attractive target for the diagnosis and therapy of prostate cancer as it specifically overexpressed in cells. Improving circulation radioligands blood considered effective strategy that can improve tumor burden, which benefits detection small lesions improves effect PSMA radioligand (PRLT). In this study, we introduced maleimidopropionic acid (MPA) to a PSMA-targeted tracer developed Al 18 F-PSMA-CM, targets human serum albumin (HSA) binding...
We aimed to develop and translate a CD20-antigen-targeted radiopharmaceutical, Technetium-99 m-labeled (99mTc) rituximab, for sentinel lymph node (SLN) detection.99mTc-rituximab was synthesized tested stability in human serum. The binding affinity CD20 evaluated Raji cells by flow cytometric analysis. Biodistribution mapping were carried out bal b/c mice. Eighty-five patients with breast cancer participated this study. Dynamic lymphoscintigraphy first assessed 12 before planar larger cohort....
Epidermal growth factor receptor (EGFR) is overexpressed in a wide variety of solid tumors, serving as well-characterized target for cancer imaging or therapy. In this study, we aimed to design and synthesize radiotracer, 64Cu-NOTA-C225, targeting EGFR tumor positron emission tomography (PET) imaging.Cetuximab (C225) was conjugated bifunctional chelator, p-isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), further radiolabeled with copper-64 PET imaging. 64Cu-NOTA-IgG...
Propose The aim of this study was to evaluate the clinical application value 18 F-FGln PET/CT in glioma. Patients and Methods with suspected gliomas by MRI were included study. Static and/or dynamic brain performed. PET parameters SUV max , mean MTV, TLG evaluated. Results Twenty-three patients analysis. Nineteen 23 positive for PET. high- low-grade 4.75 ± 2.21 1.00 0.66 ( P < 0.001), respectively. FGln-PET all showed statistically significant correlations glioma grade, correlation...
<b><i>Purpose:</i></b> This study aimed to analyze neuroendocrine neoplasm (NEN) bone metastasis (BM) and gallium-68 (<sup>68</sup>Ga)-DOTA-TATE performance explore their correlation with the immunohistochemical proliferation index (Ki-67). <b><i>Procedures:</i></b> A total of 112 patients BMs were screened from 1082 NEN who underwent [<sup>68</sup>Ga]Ga-DOTA-TATE imaging. All had pathological results, affirmed by...
Abstract PurposeDevelop a 64 Cu labeled radiopharmaceutical targeting prostate specific membrane antigen (PSMA) and investigate its application for cancer imaging. Methods Cu-PSMA-BCH was prepared investigated stability, PSMA specificity micro-PET With the approval of Ethics Committee Beijing Cancer Hospital (No. 2017KT97), PET/CT imaging in 4 patients with suspected performed radiation dosimetry estimated. Then, PET-ultrasound image-guided biopsies were on 3 fine needle aspirates further...
Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11, and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes correlation between image pathology parameters.
Objective To prepare 68Ga-PSMA-617 and perform its microPET imaging on both normal BALB/c mice BGC-823 (PSMA expression) tumor bearing mice. Methods 68GaCl3 was eluted from 68Ge-68Ga generator by 0.05 mol/L HCl, then added to the DKFZ-PSMA-617 heated at 85 ℃ for 5 min. The labeling efficiency in vitro stability of sodium chloride solution HSA were analyzed radio-HPLC. Water partition coefficient plasma protein binding rate also evaluated. MicroPET performed female human gastric...
Objective To prepare a novel somatostatin receptor (SSTR) antagonist 68Ga-1, 4, 7-triazacyclononane-1, 7-triacetic acid (NOTA)-JR11 (Cpa-c(D-Cys-Aph(Hor)-D-Aph(Cbm)-Lys-Thr-Cys)-D-Tyr-NH2) tracer and observe its biodistribution microPET imaging in mice. Methods One ml HCl (0.05 mol/L) containing 68GaCl3 (148 MBq) was added into 65 μl NaAc (1 4 μg NOTA-JR11. The mixture reacted at 95 ℃ for 15 min, then purified with Sep-Pak® C18 Light column to obtain 68Ga-NOTA-JR11. 68Ga-NOTA-JR11...