A5079553444- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Thyroid Disorders and Treatments
- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone and Joint Diseases
- Cardiovascular Function and Risk Factors
- Diabetes and associated disorders
- Hematological disorders and diagnostics
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Phagocytosis and Immune Regulation
- Blood Pressure and Hypertension Studies
- Neuroendocrine Tumor Research Advances
- Cardiovascular and Diving-Related Complications
- Lipid Membrane Structure and Behavior
- Adipokines, Inflammation, and Metabolic Diseases
- Digestive system and related health
- Heart Failure Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Tendon Structure and Treatment
- Health Systems, Economic Evaluations, Quality of Life
Nippon Medical School
2013-2024
Chiba Hokusou Hospital
2014-2024
Nippon Medical School Hospital
2010
Hoshi University
1985
Abstract Aims/Introduction α‐Glucosidase inhibitors (α GI s) are widely used for the primary treatment of type 2 diabetes. We compared clinical effects three α s (miglitol, acarbose and voglibose) in patients with obese Materials Methods Japanese ( n = 81) diabetes (body mass index [ BMI ] ≥25 kg/m ) were enrolled this multicenter, open‐label study. The participants randomized into miglitol 18), 22), voglibose 19) or control 22) groups. Glycemic (fasting blood glucose glycated hemoglobin...
We have recently reported that the attitude of patients toward risk could be a factor in progression diabetic complications. In general, preference is closely related to socioeconomic status (SES), which includes factors such as age, sex, income, and educational attainment.We aimed determine effect SES behavioral propensity on progress complications with type 2 diabetes mellitus (T2DM).We conducted survey 238 difficult-to-control T2DM treated at hospital Japan using modified economics...
The accumulation of phosphatidylcholine hydroperoxide (PCOOH), a primary oxidation product (PC), in blood plasma and tissues has been observed various pathological conditions, including atherosclerosis. However, the biological roles PCOOH these conditions remain unknown. To estimate atherogenicity PCOOH, we evaluated effect on THP-1 monocytic cell adherence to immobilized vascular endothelial adhesion molecules. intracellular molecule-1 (ICAM-1) was dose-dependently increased by addition...
Whether the dose of loop diuretics can be decreased by administration a sodium-glucose cotransporter 2 (SGLT2) inhibitor in diabetic outpatients with compensated heart failure (HF) is unclear.
Abstract Background Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events (irAEs) including thyroid dysfunction. There are only a few reports on Graves’ disease induced by ICIs. We report case of new-onset after the initiation nivolumab therapy in patient receiving gastric cancer treatment. Case presentation The was 66-year-old Japanese man, who administered (240 mg every 3 weeks) as third-line for stage IVb cancer. His function normal before therapy. However, he...
Recent studies suggest that advanced glycation end products (AGEs) can promote the development of atherosclerotic lesions in a similar manner to oxidatively modified low density lipoproteins. As oxidative stress accelerates formation AGEs, antioxidant drugs may exert atheroprotective effects via suppression AGE formation. Although amlodipine, calcium channel blocker, and fluvastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, show effects, relation AGEs their is unknown. We...
Abstract Aims/Introduction Postprandial hyperglycemia is a potent risk factor for cardiovascular disease. Serum glycated albumin ( GA ) has been reported to reflect postprandial blood glucose fluctuations. In the present study, we assessed possible correlation of with presence carotid plaque evaluate potential clinical usefulness predicting atherosclerotic complications in patients type 2 diabetes. Materials and Methods Patients diabetes n = 236) admitted Nippon Medical School Hospital...
Abstract Aims/Introduction: The development of type 2 diabetes is primarily due to lifestyle and environmental factors, as well genetics, shown by familial clustering. To establish mouse lines for evaluating heritable factors determining susceptibility diet‐induced diabetes, we performed selective breeding differences in high fat diet (HFD)‐induced glucose intolerance. Materials Methods: Selective was using hybrid mice C57BL/6J, C3H/HeJ AKR/N backgrounds. After 5‐week HFD feeding, showing...
Aim: We studied the frequency of Achilles tendon xanthoma (ATX) in patients with acute coronary syndrome (ACS). Furthermore, we investigated differences clinical findings between ACS and without ATX.
Aim: We investigated how dietary management affected body weight (BW) reduction and energy expenditure in obese normal-weight type 2 diabetic patients.Methods: Type patients who were hospitalized for control (93 men 51 women) checked resting (REE). Subjects divided into the two groups according to mass index (BMI): (BMI≥25), (BMI <25). Following recommendations by JDS, JAS JASSO, ideal was calculated as [IBW=height (m)×height (m)×22 (kg/m2)], calorie (kcal/day) determined 25 kcal/kg...
Adherence to treatment and the metabolic control of diabetes are challenging in many patients with diabetes. The theory neuroeconomics can provide important clues for understanding unreasonable human behavior concerning decisions between outcomes occurring at different time points.We investigated type 1 2 determine whether who a risk developing complications less averse. We also examined have behavioral traits decision making under risk.We conducted economics survey 219 outpatients, 66 153...
Abstract The efficacy of the administration sodium‐glucose co‐transporter 2 inhibitor or co‐administration and dipeptidyl peptidase‐4 to insulin therapy is not well known. A total 58 patients with type diabetes, admitted for glycemic control, were randomized basal–bolus ( BBT ) alone plus 50 mg ipragliflozin and/or 20 teneligliptin. Insulin doses adjusted maintain normal blood glucose levels. Plasma profiles estimated by continuous monitoring before discharge. Required significantly...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that targets the low-density lipoprotein (LDL) receptor for lysosomal degradation.PCSK9 impedes receptor-mediated clearance of LDL-cholesterol, thereby increasing serum LDL-cholesterol levels.Evolocumab, human monoclonal antibody against PCSK9, effectively reduces levels.We report first known case patient who developed an atopic dermatitis (AD)-like rash during evolocumab therapy.A 43-year-old Japanese man with...
Objective- Although postprandial hypertriglyceridemia can be a risk factor for coronary artery disease, the extent of its significance remains unknown. This study aimed to investigate correlation between lipid profiles rigorously estimated with meal tolerance test and presence lipid-rich plaque, such as thin-cap fibroatheroma (TCFA), in nonculprit lesion. Approach Results- A total 30 patients stable disease who underwent multivessel examination using optical coherence tomography during...
Background:The mechanisms of the increased plasma xanthine oxidoreductase (XOR) activity in outpatients with cardiovascular disease were unclear.
In Japan, several sodium glucose co-transporter 2 (SGLT2) inhibitors have been used for type 1 diabetes mellitus as an adjuvant therapy to insulin therapy; however, there are no clinical reports regarding the satisfaction of its use. Therefore, we conducted a survey among patients with undergoing treatment using SGLT2 inhibitor. This is single-arm open-label prospective study including 24 who were be initiated on ipragliflozin between March and August 2019. All participants provided written...
Glucagon-like peptide-1 can reduce both postprandial plasma glucose (PG) and chylomicron (CM) levels in patients with type 2 diabetes. However, there have been no reports regarding the relationship between metabolism of PG CM.Patients diabetes who were admitted for glycemic control randomized to insulin alone (Ins; n=16) or plus vildagliptin 100 mg (InsV; groups. The dose was adjusted maintain normal blood levels. daily profiles serum TG, remnant lipoprotein cholesterol (RemL-C),...