A5045293807- Bone health and treatments
- Bone and Joint Diseases
- Immune Response and Inflammation
- Gut microbiota and health
- Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Oral Health Pathology and Treatment
- Pediatric health and respiratory diseases
- Bone health and osteoporosis research
- Blood disorders and treatments
- Oral microbiology and periodontitis research
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Astro and Planetary Science
- Astronomy and Astrophysical Research
- Birth, Development, and Health
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Osteomyelitis and Bone Disorders Research
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- Pharmacogenetics and Drug Metabolism
University of Oklahoma Health Sciences Center
2025
National Institute of Dental and Craniofacial Research
2020-2024
National Institutes of Health
2020-2024
University of California, Los Angeles
2012-2023
Boston Children's Hospital
2022
Boston Children's Museum
2022
APLA Health
2012
Oklahoma State University Center for Health Sciences
2011
University of Liverpool
2006
St Mary's Hospital
1996
B Y delaying or reducing the onset of multiple late-life diseases, treatments that increase longevity could have a far greater benefi t to quality life than targeted at single diseases such as cancer heart disease ( 1 -3 ).There are numerous reports dietary additives purported cial effects in rodent models 4 -6 ), but until recently none been replicated and accepted by scientifi c community reliable reproducible result.In 2003, National Institute on Aging established NIA Interventions...
Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that certain settings, enhanced 1 immunity rather than defective can promote infection susceptibility. Notably, mice and humans with
Neutrophil infiltration is a hallmark of periodontitis, prevalent oral inflammatory condition in which Th17-driven mucosal inflammation leads to destruction tooth-supporting bone. Herein, we document that neutrophil extracellular traps (NETs) are early triggers pathogenic periodontitis. In an established animal model, demonstrate neutrophils infiltrate the gingival mucosa at time points after disease induction and expel NETs trigger bone vivo. Investigating mechanisms by drive loss, find...
The maternal microbiome is an important regulator of gestational health, but how it affects the placenta as interface between mother and fetus remains unexplored. Here, we show that gut microbiota supports placental development in mice. Depletion restricts growth impairs feto-placental vascularization. modulates metabolites fetal circulation. Short-chain fatty acids (SCFAs) stimulate cultured endothelial cell tube formation prevent abnormalities vascularization microbiota-deficient...
Drug-induced osteonecrosis of the jaw (ONJ) is a detrimental intraoral lesion that often occurs after dental-related interventions in patients undergoing treatment with bisphosphonates or denosumab, neutralizing human anti–receptor activator NF-κB ligand (RANKL) antibody (Ab). The cause ONJ by these drugs has been speculated to their direct effects on osteoclasts. However, extent which osteoclasts contribute pathogenesis remains controversial. Herein, using tooth-extraction mouse model i.v....
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) commonly occurs in individuals receiving bisphosphonates (BPs) with clinical manifestations exposed necrotic bone. Although defective wound healing soft tissue is frequently, if not always, observed BRONJ, effects BPs on oral or cells remain unknown. To investigate mucosal tissue, we studied effect pamidronate (PAM), one most administered to cancer patients, phenotypes normal human keratinocytes (NHOK) and fibroblasts (NHOF). When PAM...
Introduction The reverse question mark (RQM) incision is the conventional scalp flap technique incorporated during most decompressive hemicraniectomy (DHC) operations. Recently, retroauricular (RA) has emerged as a possible alternative. We sought to assess contemporary literature regarding postoperative outcomes following RQM or DHC for and subsequent cranioplasty. Methods MEDLINE Embase databases were queried using PRISMA-compliant search strategy methodology. Studies reporting after...
Summary p53, the guardian of genome, is a tumor suppressor protein and critical for genomic integrity cells. Many studies have shown that intracellular level p53 enhanced during replicative senescence in normal fibroblasts, viewed as cause senescence. Here, we report that, unlike reduces oncogene‐induced ( OIS ) human keratinocytes NHK s). We found was also decreased age‐dependent manner epithelial tissues. Senescent s exhibited an p16 INK4A , induced G 2 cell cycle arrest, lowered...
ABSTRACT Long-term administration of nitrogen-containing bisphosphonates can induce detrimental side effects such as bisphosphonate-related osteonecrosis the jaw (BRONJ) in human. Although inflammation is known to be associated with BRONJ development, detailed underlying mechanism remains unknown. Here, we report that pro-inflammatory cytokine IL-36α is, part, responsible for development. We found a notably higher level and lower collagen lesions mice. also remarkably suppressed...
On a thoroughbred stud four foals were born with greatly enlarged thyroids and leg weakness. Two died within 18 hours of birth, the others subsequently recovered. An thyroid was also evident in one resident mares. The from dead hyperplastic. Feed analyses showed that mares had an iodine intake about 83 mg daily, 8-8 ppm dietary dry matter, due almost entirely to high content proprietary compound horse nut which been fed at daily rate 12 lb per head. It concluded histology thyroids, iodine,...
Medication-related osteonecrosis of the jaw (MRONJ) is a rare intraoral lesion that occurs in patients undergoing long-term and/or high-dose therapy with nitrogen-containing bisphosphonates, RANKL inhibitor, antiangiogenic agents, or mTOR inhibitors. The presence pathogenic bacteria highly associated advanced stages MRONJ lesions; however, exact role indigenous microbes development unknown. Here, we report normal oral flora mice protects against inflammation-induced osteonecrosis. In...
Abstract Bacterial infection is a common finding in patients, who develop medication-related osteonecrosis of the jaw (MRONJ) by long-term and/or high-dose use anti-resorptive agents such as bisphosphonate (BPs). However, pathological role bacteria MRONJ development at early stage remains controversial. Here, we demonstrated that commensal microbiota protects against pulp-exposed periapical periodontitis mouse model. C57/BL6 female mice were treated with intragastric broad-spectrum...
SUMMARY In pregnant ewes, ovariectomized 3 weeks after mating and maintained with progesterone (7 mg./day) injected intramuscularly, there was excessive accumulation of allantoic fluid 2 months gestation. The addition oestradiol benzoate (5 μg./day) or an increase in the dose reduced volume to normal; this reduction depended on oestrogen ratio progesterone. Whilst normal, it increased incidence 'bovine' type cotyledons which are not normally seen ewes pregnant. large volumes were apparently...