A5016395000- Tryptophan and brain disorders
- Mosquito-borne diseases and control
- Health, Environment, Cognitive Aging
- Stress Responses and Cortisol
- Viral Infections and Vectors
- Child and Adolescent Psychosocial and Emotional Development
- HIV Research and Treatment
- Gut microbiota and health
- Antifungal resistance and susceptibility
- Obesity, Physical Activity, Diet
- Protein Structure and Dynamics
- Bipolar Disorder and Treatment
- Adrenal Hormones and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Fungal Infections and Studies
- HIV-related health complications and treatments
- Complement system in diseases
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Enzyme function and inhibition
- Respiratory viral infections research
- Eating Disorders and Behaviors
- Virology and Viral Diseases
- Antimicrobial Peptides and Activities
University of Pennsylvania
2021-2024
Children's Hospital of Philadelphia
2023-2024
Icahn School of Medicine at Mount Sinai
2015-2023
California University of Pennsylvania
2023
The Graduate Center, CUNY
2017
Haverford College
2013-2014
Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that certain settings, enhanced 1 immunity rather than defective can promote infection susceptibility. Notably, mice and humans with
Abstract The aim of candidate universal influenza vaccines is to provide broad protection against A and B viruses. Studies have demonstrated that broadly reactive antibodies require Fc–Fc gamma receptor interactions for optimal protection; however, the innate effector cells responsible mediating this remain largely unknown. Here, we examine roles alveolar macrophages, natural killer cells, neutrophils in antibody-mediated protection. We demonstrate macrophages play a dominant role conferring...
Invasive pulmonary aspergillosis is a life-threatening mycosis that only affects patients with immunosuppression, chemotherapy-induced neutropenia, transplantation, or congenital immunodeficiency. We studied the clinical, genetic, histological, and immunological features of 2 unrelated without known immunodeficiency who developed extrapulmonary invasive at ages 8 18. One patient died age 12 progressive intra-abdominal aspergillosis. The other had presented candidiasis 9, central nervous...
Abstract West Nile virus (WNV) is a re-emerging pathogen and the leading cause of epidemic encephalitis in United States. Inflammatory monocytes are critical component cellular infiltrate found CNS during WNV encephalitis, although molecular cues involved their migration not fully understood. In mice, we previously showed that infection induces CCR2-dependent monocytosis precedes monocyte into CNS. Currently, relative contribution CCR2 ligands, chemokines CCL2 CCL7, directing mobilization...
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a monogenic disorder caused by
HIV-1 causes a persistent infection of the immune system that is associated with chronic comorbidities. The mechanisms underlie this inflammation are poorly understood. Emerging literature has implicated proinflammatory purinergic receptors and downstream signaling mediators in infection. This study probed whether inhibitors would reduce HIV-1-stimulated inflammation. An
Several reports have demonstrated that mouse Cx3cr1 signaling promotes monocyte/macrophage survival. In agreement, we previously found that, in a model of systemic candidiasis, genetic deficiency resulted increased mortality and impaired tissue fungal clearance associated with decreased macrophage We translated this finding by showing the dysfunctional CX3CR1 variant CX3CR1-M280 was risk worse outcome human candidiasis. However, impact mutation on survival is poorly understood. Herein,...
The amino acid histidine (His) has a number of unique roles that can dictate function in proteins, and these are typically conferred through noncovalent interactions depend on the protonation state His's 4-substituted imidazole ring. vary near physiological pH, probe variable its resulting both high time resolution no sample limitations could find wide use determining role particular His residues proteins. Here we classic deuterium exchange reaction to replace C2-H hydrogen atom ring with...
West Nile virus (WNV) is a mosquito-transmitted flavivirus that can cause debilitating encephalitis. To delineate the mechanisms behind this pathology, we studied Ccr7-deficient mice, which afforded us capacity to study infection in mice with disrupted peripheral cellular trafficking events. The loss of Ccr7 resulted an immediate pan-leukocytosis remained elevated throughout infection. This leukocytosis significant enhancement leukocyte accumulation within central nervous system (CNS)....
Dendritic cells (DCs) are critical for defense against a variety of pathogens and the formation adaptive immune responses. The transcription factor Batf3 is development CD103+CD11b− DCs, which promote IL-12–dependent protective immunity during viral parasitic infections, dampen Th2 helminthic infection, exert detrimental effects bacterial infection. Whether CD103+ DCs modulate systemic or mucosal fungal disease remains unknown. Herein, we report that accumulation in kidney tongue at steady...
Background. West Nile virus (WNV) is an emerging cause of meningitis and encephalitis in the United States. Although severe neuroinvasive disease death can occur rare instances, majority infected individuals remain asymptomatic or present with a range clinical manifestations associated fever. Methods. To better understand interindividual variability WNV infections, we evaluated association cytokine/chemokine production outcome infection among 115 WNV-positive US blood donors identified...
Symmetric and asymmetric crystal structures of the apo transition state analogue forms, respectively, dimeric rabbit muscle creatine kinase have invoked an “induced fit” explanation for asymmetry between two subunits their active sites. However, previously reported thiol reactivity studies at dual active-site cysteine 283 residues suggest a more latent subunits. The role that highly conserved has also not been clearly determined. In this work, S–H vibrations Cys283 were observed in...
West Nile virus (WNV) infection outcomes vary among individuals, with most infections resulting in asymptomatic or mild flu-like symptoms. We previously reported an association between early cytokine production and symptom outcome following WNV US blood donors. In this meta-analysis, we found that WNV-infected females more symptoms than males, despite similar initial viremia type I interferon responses. As the progressed, males exhibited a protracted response-marked by sustained CCL2...
Purpose: Suicidal ideation and attempts in youth are a growing health concern, more data needed regarding their biological underpinnings. Asthma is common chronic inflammatory disorder has been associated with suicidal adolescent adult populations, but younger children early adolescents lacking. We wished to study associations of asthma childhood suicidality considering asthma’s potential as clinically relevant model for immune dysregulation. Methods: Using from the Adolescent Brain...