A5101898535- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- biodegradable polymer synthesis and properties
- Plasmonic and Surface Plasmon Research
- Advanced Biosensing Techniques and Applications
- Iron oxide chemistry and applications
- Bone Tissue Engineering Materials
- Advanced Chemical Sensor Technologies
- Catalytic Processes in Materials Science
- Microfluidic and Bio-sensing Technologies
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Asthma and respiratory diseases
- Advanced Fluorescence Microscopy Techniques
- Protein purification and stability
- Inhalation and Respiratory Drug Delivery
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Cell Image Analysis Techniques
- Graphene and Nanomaterials Applications
- Mechanisms of cancer metastasis
- Cellular Mechanics and Interactions
- Immune Response and Inflammation
National Dong Hwa University
2024
National Taiwan University
2005-2024
Taipei Medical University
2021-2023
Osaka University
2019-2021
Hiroshima University
2021
Waseda University
2015
Fooyin University
2006
Becton Dickinson (United States)
1998
Near-infrared (NIR)-light-modulated photothermal thrombolysis has been investigated to overcome the hemorrhage danger posed by clinical clot-busting substances. A long-standing issue in thrombosis fibrinolytics is lack of lesion-specific therapy, which should not be ignored. Herein, a novel therapy using disintegration fibrin clot was explored through dual-targeting glycol chitosan/heparin-decorated polypyrrole nanoparticles (GCS-PPY-H NPs) enhance thrombus delivery and thrombolytic...
Abstract New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug‐delivery systems (DDS) of bladder cancer cells (i.e., T24) controlled release magnetic guiding properties. The results MTT assay confocal laser scanning microscopy indicate that uptaken by T24 excellent biocompatibility. An anticancer drug, is, cisplatin, was used as model its...
The objective of this study is to develop a device mimic microfluidic system human arterial blood vessels. combines fluid shear stress (FSS) and cyclic stretch (CS), which are resulting from flow pressure, respectively. can reveal real-time observation dynamic morphological change cells in different fields (continuous flow, reciprocating pulsatile flow) stretch. We observe the effects FSS CS on endothelial (ECs), including ECs align their cytoskeleton proteins with direction paxillin...
In this study, a continuous cell-imaging system with subcellular resolution was developed by integrating microfluidic platform lattice lightsheet microscopy (LLSM).
A photothrombosis-on-a-chip system with precise site-specific thrombus formation, controllable severity, and dual physiological environments for drug testing thrombosis research.
Abstract Hematopoietic stem cells (HSCs) in adult bone marrow (BM) are usually maintained a state of quiescence. The cellular mechanism coordinating the balance between HSC quiescence and differentiation is not fully understood. Here, we report that galactose-binding lectin-3 (galectin-3; Gal-3) upregulated by Tie2 or Mpl activation to maintain Conditional overexpression Gal-3 mouse HSCs under transcriptional control Vav1 promoters (Gal-3 Tg) causes cell cycle retardation via induction p21....
is a commensal fungus that responsible for lot of nosocomial infections in immunocompromised people. Cell culture currently the predominant method diagnosing candidiasis, but it time consuming. In this study, we developed rapid screen procedure by devising detecting
In this study, we developed a microfluidic device that is able to monitor cell biology under continuous PM2.5 treatment.The effects of on human alveolar basal epithelial cells, A549 and uncovered several significant findings were investigated.The results showed exposure did not lead notable decrease in viability, indicating cause cellular injury or death.However, the study found increased invasion migration abilities suggesting might promote invasiveness.Results RNA sequencing revealed 423...
Escape of cancer cells from chemotherapy is a problem in the management patients. Research on resistance has mainly focused heterogeneity cells, multiple gene mutations, and quiescence malignant cells. However, some studies have indicated that interactions between vascular promote to chemotherapy. Here, we established mouse leukemia models using cell lines THP-1 or MEG-1. These were derived acute chronic myeloid leukemias, respectively, highly expressed DNA replication factor PSF1, member...
In this study, a multiplex detection system was proposed by integrating localized surface plasmon resonance (LSPR) sensing array and parallel microfluidic channels. The LSPR fabricated nanoimprinting gold sputter on polycarbonate (PC) substrate. polydimethylsiloxane (PDMS) channels PC were bound together through (3-aminopropyl)triethoxysilane (APTES) treatment oxygen plasma treatment. resonant spectrum of the device obtained broadband white-light illumination polarized wavelength...
In this study, microneedle-integrated light sheet microscopy (LSM) was developed for trapping and continuously imaging embryos of Caenorhabditis elegans with subcellular resolution. To reduce aberrations when the propagated into device, a microneedle fabricated using transparent, water refractive index-matched polymer. It proven that emerged from water-immersed objective penetrated through circular surface, even non-perpendicular incident angle, fewer were found. An embryo injected trapped...
Abstract Nanoporous iron oxide nanoparticles with superparamagnetic behavior are prepared from Prussian blue nanocubes by thermal aging of an aqueous solution PVP and K 3 [Fe(CN) 6 ] in 0.01 M HCl (80 °C, 30 h) followed decomposition air (250 400 °C,1 h).
Abstract Recently, DNA replication protein PSF-1 gets more and attention on the research field, not only plays critical role in normal cell but also involves cancer proliferation anti-apoptosis. PSF1 highly expressed many types of cancers, such as non-small lung cancer, breast colon carcinoma. However, mechanism leukemia are still uncleared. Compared to human peripheral blood mononuclear cells (PBMCs), expression level was significantly increased several leukemia, including acute chronic...
Recently, DNA replication protein PSF-1 gets more and attention on the research field, not only plays critical role in normal cell but also involves cancer proliferation anti-apoptosis. PSF1 highly expressed many types of cancers, such as non-small lung cancer, breast colon carcinoma. However, mechanism leukemia are still uncleared. Compared to human peripheral blood mononuclear cells (PBMCs), expression level was significantly increased several leukemia, including acute chronic type...