A5056969160- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Erythrocyte Function and Pathophysiology
- Sperm and Testicular Function
- Phagocytosis and Immune Regulation
- Ovarian function and disorders
- Macrophage Migration Inhibitory Factor
- Birth, Development, and Health
- Renal and related cancers
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Chromosomal and Genetic Variations
- Effects and risks of endocrine disrupting chemicals
- Cancer, Hypoxia, and Metabolism
- Trace Elements in Health
- Neurological diseases and metabolism
- Atherosclerosis and Cardiovascular Diseases
Nantong University
2022-2024
Sichuan University
2024
Huazhong Agricultural University
2015-2022
Stowers Institute for Medical Research
2019
Hubei Water Resources Research Institute
2017
Ministry of Education of the People's Republic of China
2017
Fox Chase Cancer Center
2016
Research Triangle Park Foundation
2007
Southern Medical University
1999-2001
CEBS (Chemical Effects in Biological Systems) is an integrated public repository for toxicogenomics data, including the study design and timeline, clinical chemistry histopathology findings microarray proteomics data. contains data derived from studies of chemicals genetic alterations, compatible with environmental studies. designed to permit user query using conditions, subject responses then, having identified appropriate set subjects, move module carry out gene signature pathway analysis....
The epidemiological studies regarding perfluorooctanoic acid (PFOA) suggests that its exposure causes reproductive health issues, the underlying mechanisms of which are still in infancy. Here, we report PFOA deteriorates female reproduction at multiple development stages. Oocyte meiosis and preimplantation severely impaired by with oxidative stress being a contributor. Supplementing antioxidant melatonin partially rescues oocyte meiotic maturation non-apoptotic demise. attenuation ovarian...
// Xiao-Fei Jiao 1, 2 Chun-Jie Huang Di Wu Jia-Yu Zhang Yu-Ting Long Fan Chen Xiang Li and Li-Jun Huo 1 Key Laboratory of Agricultural Animal Genetics, Breeding Reproduction, Education Ministry China, Wuhan, China College Science Technology, Huazhong University, Correspondence to: Huo, email: lijunhuo@yahoo.com Keywords: abce1, mouse oocyte, spindle assembly, chromosome alignment, aneuploidy Received: January 11, 2017     Accepted: February 22, Published: March 24, 2017...
In mammals, a finite population of oocytes is generated during embryogenesis, and proper oocyte meiotic divisions are crucial for fertility. Sperm-associated antigen 1 (SPAG-1) has been implicated in infertility tumorigenesis; however, its relevance cell cycle programs remains rudimentary. Here we explore novel role SPAG-1 progression. associated with spindles depletion severely compromised M-phase entry (germinal vesicle breakdown [GVBD]) polar body extrusion. The GVBD defect observed was...
Abstract Oocyte meiosis is a transcription quiescence process and the cell-cycle progression coordinated by multiple post-translational modifications, including SUMOylation. SENP3 an important deSUMOylation protease has been intensively studied in ribosome biogenesis oxidative stress. However, roles of regulation remain enigmatic, particularly for oocyte meiotic maturation. Here, we found that co-localized with spindles during silencing severely compromised M phase entry (germinal vesicle...