Elisha A. Frye

ORCID: 0000-0002-7784-6771
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About
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Research Areas
  • Animal Disease Management and Epidemiology
  • Viral gastroenteritis research and epidemiology
  • Influenza Virus Research Studies
  • Streptococcal Infections and Treatments
  • Brucella: diagnosis, epidemiology, treatment
  • Salmonella and Campylobacter epidemiology
  • Galectins and Cancer Biology
  • Botulinum Toxin and Related Neurological Disorders
  • Burkholderia infections and melioidosis
  • Livestock and Poultry Management
  • Milk Quality and Mastitis in Dairy Cows
  • Reproductive Physiology in Livestock
  • Clinical Laboratory Practices and Quality Control
  • T-cell and Retrovirus Studies
  • Rabies epidemiology and control
  • Helminth infection and control
  • Diphtheria, Corynebacterium, and Tetanus
  • Vector-Borne Animal Diseases
  • Genetic and phenotypic traits in livestock

Cornell University
2020-2025

New York State College of Veterinary Medicine
2020-2025

New York State Department of Health
2020

Wadsworth Center
2020

Town and Country Veterinary Clinic
2020

Abstract Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) related goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade infected wild birds, poultry, mammals. Our genomic analysis epidemiological investigation showed that a reassortment event in bird populations preceded single bird-to-cattle transmission episode. The movement of asymptomatic cattle has likely played role spread within United...

10.1101/2024.05.01.591751 preprint EN 2024-05-01

Infections with the highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b virus have resulted in death of millions domestic birds and thousands wild U.S. since January, 2022. Throughout this outbreak, spillovers to mammals been frequently documented. Here, we report detection HPAI dairy cattle herds across several states The affected cows displayed clinical signs encompassing decreased feed intake, altered fecal consistency, respiratory distress, milk production abnormal milk....

10.1101/2024.05.22.595317 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-05-22

Salmonella Dublin infections in heifer-raising operations (HROs) cause animal health and economic losses for these represent a pathogen source dairy farms obtaining replacement heifers from HROs. To improve control of S. Dublin, we (i) developed mathematical model transmission on HRO, (ii) evaluated the vaccine effectiveness cleaning improvements controlling infection, (iii) influence infection strategies HRO's operating income. We modified Susceptible-Infected-Recovered-Susceptible spread...

10.1101/2025.01.08.630693 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2025-01-13

<title>Abstract</title> We investigated the impact of influenza A-H5N1 virus infection in a dairy herd. Clinical disease, which lasted for about three weeks, was recorded 20.0% (777/3,876) adult cows. Milk losses ~900 kg per cow were affected cows during 60 day-post-outbreak period. Seroprevalence 89.4% (570/637) herd, with 76.1% (485/637) seropositive animals being subclinically infected. Clinically presented an increased risk death (6 times) and premature herd removal (3.6 times), when...

10.21203/rs.3.rs-6101018/v1 preprint EN cc-by Research Square (Research Square) 2025-03-03

Abstract Objective To analyze the results and metadata of canine, feline, equine respiratory PCR panel assays performed at New York State Animal Health Diagnostic Center inform veterinary diagnostic sample submission. Methods This retrospective study reviewed laboratory data from routine submissions to for panels January 1 through December 31, 2023. Associations were compared between variables using χ 2 tests independence or Fisher exact tests. Results A total 1,902 (705 189 1,008 equine)....

10.2460/javma.24.11.0755 article EN Journal of the American Veterinary Medical Association 2025-03-25

Brucella canis is a zoonotic bacterial pathogen of dogs that notoriously difficult to diagnose and treat. Humans can become infected with B when an pet dog brought into their home. Our objectives were describe the clinical presentation outcomes in treated for evaluate performance quantitative serologic canine multiplex (CBM) assay monitoring treatment response.Diagnostic records from Animal Health Diagnostic Center at Cornell University retrospectively reviewed (2017-2022) underwent repeat...

10.2460/ajvr.23.01.0014 article EN cc-by-nc American Journal of Veterinary Research 2023-03-09

Thirty-four Holstein calves from multiple farms were found recumbent during the neonatal period with no detectable neurologic, infectious, or metabolic abnormalities. Most did not survive beyond 6 wk of age. The objective this study was to conduct a genome-wide association and pedigree analysis determine if genetic origin plausible. There 101,917 DNA markers for 18 affected 26 unaffected family controls available analysis. Genome-wide association, homozygosity screening, parental based...

10.3168/jdsc.2022-0224 article EN cc-by JDS Communications 2022-08-06

Twenty-eight lactating dairy cattle in New York State were exposed to botulism toxin; 12 died and 16 recovered but never returned full productivity. Pieces of a raccoon carcass found the total mixed ration on first day outbreak. Clinical signs included anorexia, decreased milk production, tongue tone, profound weakness, recumbency. Clostridium botulinum type A (BoNT/A) was detected rumen contents from 2 deceased cows via matrix-assisted laser desorption/ionization time-of-flight mass...

10.1177/1040638720943127 article EN Journal of Veterinary Diagnostic Investigation 2020-07-25

Salmonella Dublin is a zoonotic, multi-drug-resistant bacteria. It host adapted in cattle, and carrier animals shed bacteria feces milk, acting as reservoir for the herd. causes septicemia young calves, who present with high fever, increased respiratory effort acute death. Diag­nosing an acutely infected calf requires aseptic collection of blood culture sample, storage at room temperature or incubator, overnight delivery to vet­erinary diagnostic laboratory. Diagnosing post-mortem submission...

10.21423/aabppro20218310 article EN American Association of Bovine Practitioners Conference Proceedings 2021-10-09
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