A5052328375- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- Cell Adhesion Molecules Research
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Bird parasitology and diseases
- Cellular Mechanics and Interactions
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Viral gastroenteritis research and epidemiology
- Rhetoric and Communication Studies
- Forensic Entomology and Diptera Studies
- Influenza Virus Research Studies
- Microbial infections and disease research
- Trypanosoma species research and implications
- Contemporary Literature and Criticism
- Virology and Viral Diseases
- Law in Society and Culture
- Animal Disease Management and Epidemiology
- Research on Leishmaniasis Studies
- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- Platelet Disorders and Treatments
- Coccidia and coccidiosis research
- Primate Behavior and Ecology
Wellborn Road Veterinary Medical Center
2019-2024
Texas A&M University
2016-2022
The Wallace H. Coulter Department of Biomedical Engineering
2015-2020
Georgia Institute of Technology
2015-2020
AID Atlanta
2017-2020
Parker Hannifin (United States)
2017
Universidade Federal de Lavras
2017
University of California, Davis
2017
University of Mary
2016
University of Georgia
2015-2016
The highly pathogenic avian influenza (HPAI) H5N1 virus clade 2.3.4.4b has caused the death of millions domestic birds and thousands wild in USA since January 2022 (refs.
Infections with the highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b virus have resulted in death of millions domestic birds and thousands wild U.S. since January, 2022. Throughout this outbreak, spillovers to mammals been frequently documented. Here, we report detection HPAI dairy cattle herds across several states The affected cows displayed clinical signs encompassing decreased feed intake, altered fecal consistency, respiratory distress, milk production abnormal milk....
Identification of fungal organisms often poses a problem for pathologists because the histomorphology some is not specific, fresh tissues may be available, and isolation identification in culture take long time. The purpose this study was to validate use panfungal polymerase chain reaction (PCR) identify from formalin-fixed paraffin-embedded (FFPE) tissues. Formalin-fixed curls were tested 128 blocks containing canine, feline, equine, bovine with cutaneous, nasal, pulmonary, systemic...
Most small ruminant farms in tropical climates are plagued by Haemonchus contortus, a hematophagous, abomasal parasite. Heavy burdens of this parasite can cause anemia, hypoproteinemia, weight loss, and mortality susceptible animals. contortus is becoming major health concern New World camelids as well, namely llamas (Llama glama) alpacas (Vicugna pacos), yet little research has been conducted regarding its prevalence or pathology these species. Herein, we present retrospective review that...
We describe the diagnostics surrounding deaths of five working dogs over six-months to provide an enhanced clinical and diagnostic understanding canine Chagas disease. Cases were with antibodies Trypanosoma cruzi. Medical records reviewed for history. Testing was performed from samples collected before or immediately after death, including measurement cardiac troponin I, histology, PCR serology Leishmania spp. T. Four had a 2 7-year history cruzi antibodies, while one positive dog unknown...
Trypanosoma cruzi is a vector-borne, protozoal parasite of mammals. Infected humans, dogs (Canis lupus familiaris), and nonhuman primates may remain asymptomatic or develop Chagas disease, most commonly characterized by lymphoplasmacytic myocarditis with myocardial degeneration fibrosis, ultimately resulting in heart failure. Although wildlife species have important roles as sylvatic reservoirs, investigations into the pathology T. are limited to few studies documenting histologic lesions...
Selectins facilitate the recruitment of circulating cells from bloodstream by mediating rolling adhesion, which initiates cell-cell signaling that directs extravasation into surrounding tissues. To measure relative efficiency cell adhesion in shear flow for vitro drug screening, we designed and implemented a microfluidic-based analytical chromatography system. The juxtaposition instantaneous velocities with elution times revealed human metastatic cancer but not leukocytes have reduced...
P-Selectin/ICAM-1 co-presentation enhances THP-1 firm adhesion and decreases the length of adhesive substrate required for in flow.
Sexually transmitted diseases (STDs) can persist endemically, are known to cause sterility and infant mortality in humans, could have similar impacts wildlife populations. African apes (i.e., chimpanzees, bonobos, a lesser extent gorillas) show multi‐male mating behavior that offer opportunities for STD transmission, yet little is about the prevalence impact of STDs this endangered primate group. We used serology PCR‐based detection methods screen biological samples from wild orphaned...
An integrated, parallel-plate microfluidic device is engineered to interrogate and fractionate cells based on their adhesivity a substrate surface functionalized with adhesive ligand in tightly controlled flow environment elucidate associated cell-intrinsic pathways. Wall shear stress levels endothelial presentation of E-selectin are modeled after the inflamed vasculature microenvironment order simulate vitro conditions under which vivo hematogenous metastasis occurs. Based elution time from...
The ability of leukocytic cells to engage selectins via rolling adhesion is critical inflammation, but are also implicated in mediating metastatic dissemination. Using a microfluidic- and flow-based cell chromatography experimental analytical technique, we interrogated the cell-subtype differences engagement sustainment on P-, E-, L-selectin-functionalized surfaces physiological flow. Our results indicate that, particularly at low concentrations P-selectin, not exhibit reduced persistence,...
To delineate the influence of hemodynamic force on cell adhesion processes, model in vitro fluidic assays that mimic physiological conditions are commonly employed. Herein, we offer a framework for solution three-dimensional Navier–Stokes equations using computational fluid dynamics (CFD) to estimate forces resulting from flow near plane acting sphere is either stationary or free flow, and compare these results widely used theoretical assumes Stokes with constant shear rate. We find while...
A northern crested caracara (Caracara cheriway) was presented after being found nonambulatory in a field. On physical examination, the bird had severe hind-limb paresis. The did not improve 10 days of hospitalization and euthanized. Histologic examination cerebrum spinal cord revealed multiple adult filarial nematodes surrounded by granulomatous inflammation with several multinucleated giant cells. These parasites were confirmed to be Chandlerella quiscali polymerase chain reaction. This is...
The high morbidity rate of ovarian cancer has remained unchanged during the past four decades, partly due to a lack understanding disease mechanisms and difficulties in developing new targeted therapies. Defective DNA damage detection repair is one hallmarks cells defining characteristic cancer. Most vitro studies date involve viability measurements at scale using relevant cell lines; however, translation clinic often lacking. use patient derived organoids closing that translational gap, yet...
Osteogenesis imperfecta, also known as ‘brittle bone disease’, is an inherited connective tissue disorder caused by defects in type 1 collagen. The disease results low mass and reduced strength, often manifesting multiple intrauterine fractures, skeletal abnormalities death before adulthood. A four‐month‐old, female entire, English mastiff was presented for limb fractures. Due to a poor prognosis, euthanasia elected. Gross examination revealed diffuse osteopenia with chronic acute All adult...
Extremities of the Body:The Anoptic Corporeality As I Lay Dying Erin E. Edwards From point view death, disease has a land, mappable territory, subterranean, but secure place where its kinships and consequences are formed; local values define forms. Paradoxically, presence corpse enables us to perceive it living—living with life that is no longer either old sympathies or combinative laws complications, one own roles laws. —Michel Foucault, The Birth Clinic Martin Jay claims materializing...
Abstract Background Onchocerca lupi is an emerging, zoonotic filarioid nematode associated with ocular disease in companion animals North America and the Old World. The areas where this parasite assumed to be endemic USA comprise southwestern states. Thus far, all cases reported outside of southwest are travel or animal movement. Methods An 11-year-old, castrated male Pitbull dog from McAllen, Hidalgo County, southern Texas, no history, was diagnosed a perforating corneal ulceration right...
Concurrent Clostridium piliforme and canine distemper virus (CDV) infection was diagnosed in 2 littermates 1 gray fox kit from Texas, USA. In all 3 animals, intracytoplasmic, filamentous bacteria, consistent with C. piliforme, were present along the margins of foci hepatic necrosis. Additional histologic findings included intracytoplasmic intranuclear inclusion bodies bile duct bronchial epithelial cells kit, mild intestinal necrosis puppy. PCR assays confirmed presence CDV both puppies,...
Onchocerca lupi is an emerging, zoonotic filarioid nematode associated with ocular disease in companion animals. We report the first autochthonous case of O. a dog from Hidalgo County, southern Texas, USA. An 11-year-old, castrated male, Pitbull McAllen, Texas no travel history, was diagnosed perforating corneal ulceration right eye. Enucleation performed, and tissues submitted for histopathology. Sections two nematodes were observed. Parasite identification relied on morphological features...