A5011877401- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS Research and Interventions
- Healthcare cost, quality, practices
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Adolescent Sexual and Reproductive Health
- Health Systems, Economic Evaluations, Quality of Life
- Clinical Reasoning and Diagnostic Skills
- HIV, Drug Use, Sexual Risk
- Antibiotic Use and Resistance
- Infective Endocarditis Diagnosis and Management
- Hepatitis Viruses Studies and Epidemiology
- Meta-analysis and systematic reviews
- Emergency and Acute Care Studies
- Infectious Diseases and Tuberculosis
- Musculoskeletal synovial abnormalities and treatments
- Mast cells and histamine
- Primary Care and Health Outcomes
- Acute Myocardial Infarction Research
- Malaria Research and Control
- Hepatitis C virus research
- Enterobacteriaceae and Cronobacter Research
Prince Charles Hospital
2018-2024
The University of Queensland
2015-2023
San Diego State University
2022
Royal Brisbane and Women's Hospital
2015-2021
Gold Coast Health
2020
Research Research (South Africa)
2020
To characterize MDR Escherichia coli from bloodstream infections (BSIs) in Australia, New Zealand and Singapore.We collected third-generation cephalosporin-resistant (3GC-R) E. blood cultures patients enrolled a randomized controlled trial February 2014 to August 2015. WGS was used antibiotic resistance genes, MLST, plasmids phylogenetic relationships. Antibiotic susceptibility determined using disc diffusion Etest.A total of 70 3GC-R were included, which the majority ST131 (61.4%). BSI most...
Background. Infections caused by carbapenem-resistant Acinetobacter baumannii (CR-Ab) have become increasingly prevalent in clinical settings and often result significant morbidity mortality due to their multidrug resistance (MDR). Here we present an integrated whole-genome sequencing (WGS) response a persistent CR-Ab outbreak Brisbane hospital between 2016-2018.Methods. A. baumannii, Klebsiella pneumoniae, Serratia marcescens Pseudomonas aeruginosa isolates were sequenced using the Illumina...
To investigate the epidemiology, clinical characteristics and outcomes of those with hepatitis delta virus (HDV) infection in Queensland, Australia.Retrospective cohort study individuals tested for HDV between 1997 2016 public healthcare system Queensland.179 recorded positive serology 2016, a total 4407 undergoing testing (seroprevalence 4.1%). The majority were male born overseas. Those Africa had higher risk ratio (RR) (RR, 1.55; 95% CI, 1.14-2.09); being Asia was associated relatively...
We aimed to identify a gene signature that discriminates between sepsis and aseptic inflammation in patients administered antibiotics the intensive care unit compare it commonly utilised biomarkers.91 commenced on were retrospectively diagnosed as having: (i) blood culture positive sepsis; (ii) negative or (iii) inflammation. Bloods collected after <24 h of antibiotic commencement for both expression sequencing analysis measurement previously identified biomarkers.53 differentially expressed...
Understand the long-term mortality, risk of readmission for sepsis and cause death following a gram-negative bloodstream infection (GN-BSI).This was propensity-matched study using data linkage Queensland hospital data, Australia. GN-BSIs were collected from 2005 to 2010 matched 1:1 admissions without BSI age, gender, year culture collection, frequency in prior Charlson-Deyo Comorbidity score each comorbidity within score. Readmissions sepsis, mortality causes evaluated.Cases GN-BSI...
It has been described that the sensitivity of Carba NP test may be low in case OXA-48-like carbapenamases and mass spectrometry based methods as well a colorimetry method have alternatives. We evaluated 84 Enterobacteriaceae isolates including 31 producing 13 produced either an imipenemase (IMP; n = 8), New Delhi metallo-β-lactamase (NDM; 3), or Klebsiella pneumoniae carbapenemase (KPC; 2), 40 negative isolates. used Neo-Rapid CARB kit, assessing results with unaided eye compared it...
The relationship between acute myocardial infarction and infection was recognized in the early 20th century during influenza epidemics. Most recently, a case control study self-control design have identified an association Staphylococcus aureus infarction. We assessed of community-acquired bloodstream (CA-SABSI) 365 days following blood culture.This cohort assessing incidence after culture for aureus. Culture-negative patients had cultures collected at hospital attendance were matched to...
Sir,A case of multifocal varicella zoster virus (VZV) vasculopathy in an immunocompetent subject was recently reported the present journal.[1] The importance clinical awareness associa...
Prosthetic pulmonary valve endocarditis is a rare but serious infective complication following correction of tetralogy Fallot (ToF). We describe probable zoonotic case Streptococcus equi subspecies zooepidemicus prosthetic in young woman with corrected ToF regular exposure to horses. The was further complicated by acalculous cholecystitis, which the initial presenting syndrome, requiring laparoscopic cholecystectomy. Microbiological analysis blood cultures yielded growth S. whole genome...
A 50-year-old woman with a history of bilateral knee replacements developed acute-onset painful effusions and inability to weight-bear. She was systemically well, but 2 days before the onset her symptoms, she received an influenza vaccination. Synovial fluid analysis revealed white cell count (WCC) 190,000 × 109, 85% polymorphomuclear lymphocytes (PMN) on left WCC 252,200 89% PMN right knee. Debridement implant retention polyethylene exchange performed. Extended bacterial culture negative as...
Abstract Infections caused by carbapenem-resistant Acinetobacter baumannii (CR-Ab) have become increasingly prevalent in clinical settings and often result significant morbidity mortality due to their multidrug resistance (MDR). Here we present an integrated whole genome sequencing (WGS) response a polymicrobial outbreak Brisbane hospital between 2016-2018. 28 CR-Ab (and 21 other MDR Gram negative bacilli) were collected from Intensive Care Unit Burns patients sent for WGS with 7-day...
Abstract Background: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In the intensive care unit (ICU), common. The challenge lies in determining when can be attributed We aimed retrospectively determine what proportion of patients commenced on antibiotics for presumed sepsis mixed ICU had blood-culture positive sepsis, negative or an aseptic mimic.Methods: One hundred antibiotic naïve who were clinically deemed have infection...