A5031832667- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Microscopic Colitis
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Escherichia coli research studies
- Bacterial Identification and Susceptibility Testing
- Salmonella and Campylobacter epidemiology
- Bacterial biofilms and quorum sensing
- Acute Ischemic Stroke Management
- Bacterial Genetics and Biotechnology
- Pneumonia and Respiratory Infections
- Venous Thromboembolism Diagnosis and Management
- Bacteriophages and microbial interactions
- Streptococcal Infections and Treatments
- Molecular Biology Techniques and Applications
- Neonatal and Maternal Infections
- Bacterial Infections and Vaccines
- Antibiotic Use and Resistance
- Attachment and Relationship Dynamics
- Child and Adolescent Psychosocial and Emotional Development
- Vibrio bacteria research studies
- Atrial Fibrillation Management and Outcomes
Leipzig University
2022-2025
The University of Queensland
2013-2024
University Hospital of Zurich
2021-2024
University of Zurich
2024
University Hospital Leipzig
2023
École nationale des ponts et chaussées
2023
Freie Universität Berlin
2023
Robert Koch Institute
2018-2022
Royal Brisbane and Women's Hospital
2013-2015
Swiss Tropical and Public Health Institute
2008-2013
Abstract Background Escherichia coli is an opportunistic pathogen which colonizes various host species. However, to what extent genetic lineages of E. are adapted or restricted specific hosts and the genomic determinants such adaptation restriction poorly understood. Results We randomly sampled isolates from four countries (Germany, UK, Spain, Vietnam), obtained five species (human, pig, cattle, chicken, wild boar) over 16 years, both healthy diseased hosts, construct a collection 1198...
The objective of this study was to determine the activity fidaxomicin and comparator antimicrobials against Clostridium difficile isolated from patients with C. infection (CDI) in Australian hospitals community. One private one public laboratory five states Australia submitted a total 474 isolates/PCR-positive stool samples during three collection periods August–September 2013 (n = 175), February–March 2014 134) 165). Isolate identification confirmed by selective culture for proportion...
Pathogens frequently associated with multi-drug resistant (MDR) phenotypes, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and Acinetobacter baumannii isolated from horses admitted to horse clinics, pose a risk for animal patients personnel in clinics. To estimate current rates of colonization, total 341 equine were screened carriage zoonotic indicator pathogens at hospital admission. Horses showing clinical signs colic (n = 233) or open wounds 108)...
Introduction Venous thromboembolic events (VTEs) like deep vein thrombosis or pulmonary embolism are frequent complications in (neuro) critical ill patients. Anticoagulation for VTE after space-occupying brain infarction is a therapeutic dilemma. The aim of this retrospective study was to investigate the frequency clinically apparent patients with acute ischaemic stroke (AIS) due large vessel occlusion (LVO), its treatment, and rate complications. Methods Patients first AIS LVO were assigned...
The zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. colonises many wild animals and livestock, persistence mechanisms enabling bacterium to adapt host species' guts are not fully understood. In order identify putative determinants influencing preferences distinct lineages, bootstrapping based on stratified random sampling combined with a k-mer-based genome-wide association was conducted 490 genomes from diverse origins in Germany...
Atrial fibrillation (AF) is one of the most frequent causes stroke. Several randomized trials have shown that prolonged monitoring increases detection AF, but effect on reducing recurrent cardioembolism, ie, ischemic stroke and systemic embolism, remains unknown. We aim to evaluate whether a risk-adapted, intensified heart rhythm with consequent guideline conform treatment, which implies initiation oral anticoagulation (OAC), leads reduction cardioembolism.Find-AF 2 randomized, controlled,...
Ninety-five colonizing isolates and 74 invasive of Streptococcus agalactiae from Kenyan adults were characterized by using capsular serotyping multilocus sequence typing. Twenty-two types clustering into five clonal complexes found. Data support the view that S. belonging to a limited number are in worldwide.
Abstract Camels are the most valuable livestock species in Horn of Africa and play a pivotal role nutritional sustainability for millions people. Their health status is therefore utmost importance people living this region. Streptococcus agalactiae, Group B (GBS), an important camel pathogen. Here we present first epidemiological study based on genetic phenotypic data from African derived GBS. Ninety-two GBS were characterized using multilocus sequence typing (MLST), capsular polysaccharide...
Continuing introduction of multi-drug resistant, zoonotic pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) in horse clinics challenges the biosafety employees and animal patients. This study was aimed to determine occurrence mobile genetic elements facilitating survival early stages invasive infection different host species, including humans horses, MRSA carried by equine patients admitted a large clinic. A total 341 were investigated for carriage hygiene screening...
Clostridium difficile infection (CDI) is becoming less exclusively a health care-associated CDI (HA-CDI). The incidence of community-associated (CA-CDI) has increased over the past few decades. It been postulated that asymptomatic toxigenic C. (TCD)-colonized patients may play role in transfer between hospital setting and community. Thus, to investigate relatedness across community settings, we compared characteristics symptomatic host pathogens from these two settings 3-year period. Two...
ABSTRACT The highly immunogenic mycobacterial proteins ESAT-6, CFP-10, and HspX represent potential target antigens for the development of subunit vaccines immunodiagnostic tests. Recently, complete genome sequence revealed absence these coding sequences in Mycobacterium ulcerans , causative agent emerging human disease Buruli ulcer. Genome reduction acquisition a cytopathic immunosuppressive macrolide toxin plasmid are regarded as crucial emergence this pathogen from its environmental...
Abstract Functionality of the accessory gene regulator ( agr ) quorum sensing system is an important factor promoting either acute or chronic infections by notorious opportunistic human and veterinary pathogen Staphylococcus aureus . Spontaneous alterations are known to frequently occur in healthcare-associated S. lineages. However, data on integrity function sparse regarding other major clonal Here we report functionality activity level mec C-carrying methicillin resistant (MRSA) various...
Abstract Background Campylobacter jejuni is a zoonotic pathogen that infects the human gut through food chain mainly by consumption of undercooked chicken meat, raw cross-contaminated ready-to-eat or milk. In last decades, C. has increasingly become most common bacterial cause for food-born infections in high income countries, costing public health systems billions euros each year. Currently, different whole genome sequencing techniques such as short-read bridge amplification and long-read...
It has been described that the sensitivity of Carba NP test may be low in case OXA-48-like carbapenamases and mass spectrometry based methods as well a colorimetry method have alternatives. We evaluated 84 Enterobacteriaceae isolates including 31 producing 13 produced either an imipenemase (IMP; n = 8), New Delhi metallo-β-lactamase (NDM; 3), or Klebsiella pneumoniae carbapenemase (KPC; 2), 40 negative isolates. used Neo-Rapid CARB kit, assessing results with unaided eye compared it...