A5067183767- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Virus-based gene therapy research
- Neurological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Medical and Health Sciences Research
- Clinical practice guidelines implementation
- Viral Infectious Diseases and Gene Expression in Insects
- Nerve injury and regeneration
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Interference and Gene Delivery
- Cerebrovascular and Carotid Artery Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Health and Medical Studies
- Balance, Gait, and Falls Prevention
- COVID-19 and healthcare impacts
- Healthcare Technology and Patient Monitoring
- Metabolism, Diabetes, and Cancer
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Intracranial Aneurysms: Treatment and Complications
- Pancreatic function and diabetes
University of Augsburg
2024
University Hospital Augsburg
2019-2023
University Hospital Carl Gustav Carus
2023
TU Dresden
2023
Evangelisches Krankenhaus Bielefeld
2023
University of Göttingen
2019
Heinrich Heine University Düsseldorf
2004-2010
Weizmann Institute of Science
2009
University of Freiburg
2000-2001
National Institutes of Health
2000
Atrial fibrillation (AF) is one of the most frequent causes stroke. Several randomized trials have shown that prolonged monitoring increases detection AF, but effect on reducing recurrent cardioembolism, ie, ischemic stroke and systemic embolism, remains unknown. We aim to evaluate whether a risk-adapted, intensified heart rhythm with consequent guideline conform treatment, which implies initiation oral anticoagulation (OAC), leads reduction cardioembolism.Find-AF 2 randomized, controlled,...
The mechanisms preventing efficient remyelination in the adult mammalian central nervous system after demyelinating inflammatory diseases, such as multiple sclerosis, are largely unknown. Partial occurs early disease stages, but repair capacity diminishes over time and with progression. We describe a potent candidate for negative regulation of oligodendroglial differentiation that may underlie failure to remyelinate. p57kip2 gene is dynamically regulated spinal cord during MOG-induced...
<h3>BACKGROUND AND PURPOSE:</h3> Large intracranial vessel occlusion due to calcified emboli is a rare cause of major stroke. We assessed the prevalence, imaging appearance, effectiveness mechanical thrombectomy, and clinical outcome patients with large-vessel emboli. <h3>MATERIALS METHODS:</h3> performed retrospective analysis procedural data consecutive who underwent thrombectomy in 7 European stroke centers. <h3>RESULTS:</h3> screened 2969 patients, 40 matched inclusion criteria,...
Introduction: As prospective data on long-term patient-reported outcome measures (PROMs) to assess Health related Quality of Life (HRQoL) after stroke are still scarce, this study examined the course PROMs and investigated influential factors such as recanalization therapies. Materials Methods: A total 945 (mean age 69 years; 56% male) patients were enrolled with a personal interview chart review performed at index event. One hundred forty (15%) received thrombolysis (IVT) 53 (5%)...
The objective of the STREAM Trial was to evaluate effect simulation training on process times in acute stroke care.The multicenter prospective interventional conducted between 10/2017 and 04/2019 at seven tertiary care neurocenters Germany with a pre- post-interventional observation phase. We recorded patient characteristics, times, team composition experience for consecutive direct-to-center patients receiving intravenous thrombolysis (IVT) and/or endovascular therapy (EVT). intervention...
Background Post-stroke fatigue is a common symptom after stroke. However, studies on the factors associated with early and late are scarce. The objective of this study was to identify variables fatigue. Methods In German Stroke Cohort Augsburg (SCHANA) study, participants were interviewed during their hospital stay completed postal questionnaire 3 12 months post-stroke. Fatigue assessed using Assessement Scale (FAS). addition, depression measured by Patient Health Questionnaire (PHQ-9),...
High throughput technologies provide new opportunities to further investigate the pathophysiology of ischemic strokes. The present cross-sectional study aimed evaluate potential associations between etiologic subtypes stroke and blood-based proteins.
Telemedical stroke networks improve care and provide access to time-dependent acute treatment in predominantly rural regions. The aim is a presentation of data on its utility regional distribution.The working group telemedical the German Stroke Society performed survey study among all telestroke networks.Currently, 22 including 43 centers (per network: median 1.5, interquartile range, IQR, 1-3) as well 225 cooperating hospitals 9, IQR 4-17) operate Germany contribute delivery 48 million...
The optimal anesthetic management for endovascular therapy (EVT) in patients with posterior circulation stroke remains unclear. Our objective was to investigate the impact of early intubation enrolled BASICS trial (Basilar Artery International Cooperation Study).
Transected axons can regenerate beyond the site of injury in peripheral but not central nervous system (CNS). Increasing evidence implicates inflammatory processes as modulators axon regeneration after injury. In this study, we addressed a possible role matricellular glycoprotein osteopontin (OPN) using crush lesions optic and sciatic nerve models axotomy, respectively. OPN was strongly expressed by macrophages at nerve, indicating fundamental differences molecular programming both systems....
A 27-year-old woman extracted her right subclavian venous catheter, sat up and experienced a convulsive syncope. Cerebral CT 30 min later showed transient air embolism in both cavernous sinuses. Retrograde cerebral is rare but potentially fatal complication of central catheters. Fig. 1. , b revealed bilateral the sinus. c Air bubbles were completely reabsorbed 5 h later. Dr. Philipp Zickler Department Neurology, Heinrich Heine University Dusseldorf Moorenstrasse DE–40225 (Germany) Tel. +49...
Background Much is known about the association between physical activity and occurrence of stroke. However, evidence correlation pre-stroke post-stroke quality life remains inconsistent. Thus, there a high public health relevance to topic. Aim The aim this study was investigate after three months. Methods Data arises from 858 patients with stroke included prospective single-centre observational cohort in Augsburg, Germany, September 2018 November 2019. participants were recruited at...
A bstract : The semirandom location of retroviral integration in the target cell genome introduces a marker form fusion sequence composed genomic and proviral part that is unique for each transduced its clonal progeny. High‐sensitivity detection these sequences would allow tracking contributions individual, marked hematopoietic progenitor, stem cells vivo . Clone by Southern blot has helped to analyze models oligoclonal repopulation but limited sensitivity specificity. Inverse PCR (Nolta et...
Introduction: Acute stroke care delivered by interdisciplinary teams is time-sensitive. Simulation-based team training a promising tool to improve performance in medical operations. It has the potential process times, communication, patient safety and staff satisfaction. We aim assess whether multi-level approach consisting of stringent workflow revision based on peer-to-peer review 2-3 one-day situ simulation trainings can acute processing times high volume neurocenters within six months....
Introduction: In Germany, stroke is the third leading cause of death, with more than 60,000 fatalities out approximately 260,000 cases (first-ever and recurrent strokes) each year. So far, there are only a few long-term studies investigating determinants natural course disease, especially in era mechanical thrombectomy. Materials Methods: The prospective single-center cohort Augsburg (SCHANA) study will include about 1000 patients treated for University Hospital Augsburg. Patients aged 18...
Chronic fatigue is a common symptom after stroke. Studies suggested that chronic caused by inflammatory or immunological processes but data are limited and contradictory. Thus, the present study aimed to identify specific biomarkers associated with in post-stroke patients replicated findings population-based study.We investigated associations between 39 circulating of inflammation 327 an ischemic stroke included Stroke Cohort Augsburg (SCHANA) "Metabolism, Nutrition Immune System Augsburg"...
The effects of the coronavirus disease 2019 (COVID-19) pandemic on telemedical care have not been described a national level. Thus, we investigated medical stroke treatment situation before, during, and after first lockdown in Germany.In this nationwide, multicenter study, data from 14 networks including 31 network centers 155 spoke hospitals covering large parts Germany were analyzed regarding patients' characteristics, type/severity, acute treatment. A survey focusing potential...
Approximately one-third of patients with stroke show depressive symptoms. The so-called post-stroke depression (PSD) has a negative influence on mortality as well physical and mental conditions. aim this study was to analyse the association between PSD health-related quality life (HRQOL) in stroke. analysis based data 326 from Stroke Cohort Augsburg (SCHANA Study) collected after event by interview three months later using postal survey. Depressive symptoms were measured Patient-Health...
Acute stroke treatment and secondary prevention have tremendously improved functional outcomes after stroke. However, this does not always imply a likewise improvement in health-related quality of life (HRQoL). Knowledge on factors influencing HRQoL is still scarce, especially regarding social aspects like the level education presence migration background.In present cohort study, participants were interviewed during their hospital stay completed postal questionnaire at 3 12 months post...
Axon regrowth after nerve injury can occur in the peripheral but fails central nervous system. Cellular reactions at lesion site affect axonal regrowth. We compared gene regulation optic (ON) and sciatic (SN) crush lesions adult rats by cDNA array analysis, quantitative RT-PCR immunohistochemistry, focusing on primary rather than proximal or distal stump. Four days injury, identical ON SN was found for 19/1185 genes (15 up, 4 down). In contrast, tissue-specific regulations were identified 48...
Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part the clinical spectrum ALS.Unlike ALS, which familial 5 to 10% cases, PLS has been described as sporadic disorder adults.The authors report two from unrelated SOD1-negative ALS families.These observations provide further evidence that can linked pathophysiologically ALS.
Telestroke networks aim to improve acute stroke care within their catchment area. Through a teleconsultation service, the network centers provide support hospitals that lack continuous neurological expertise for management decisions. Although importance of telemedical treatment in is steadily increasing, so far no standards exist organization service networks.To ensure high-level quality all processes and measures concerning treatment, commission German Stroke Society (Deutsche...
Besides functional outcomes, mental health and health-related quality of life (HRQoL) are significant measures in chronic diseases, such as stroke. Post-stroke depression (PSD) is an important complication affecting up to one three stroke survivors. So far, specific programs screen, detect treat these patients lacking but might be a crucial component aftercare.