A5000568184- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Click Chemistry and Applications
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Advanced Proteomics Techniques and Applications
- Galectins and Cancer Biology
- Advanced biosensing and bioanalysis techniques
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Multiple Myeloma Research and Treatments
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Single-cell and spatial transcriptomics
University of Glasgow
2025
Cancer Research UK
2024
Cancer Research UK Scotland Institute
2022-2023
GlaxoSmithKline (United Kingdom)
2019-2021
The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically mutated regions of cancer genome, but whether these mutations impact tumor biology debated. We engineered truncating mtDNA-encoded complex I gene, Mt-Nd5, into several murine models melanoma. These promoted a Warburg-like shift that reshaped microenvironments in both mice humans, consistently eliciting an anti-tumor immune response...
The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators the epigenome through their ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails. These interactions have been implicated in various disease states and, consequently, disruption BET-KAc binding has emerged as an attractive therapeutic strategy with a number small molecule inhibitors now under investigation clinic. However, until utility these...
T-cell receptor recognition of cognate peptide–MHC leads to the formation signalling domains and immunological synapse. Because close membrane apposition, there is rapid exclusion CD45, therefore LCK activation. Much less known about whether spatial regulation intracellular face dictates activity TCR signal transduction. Moreover, as a driver in T acute lymphocytic leukaemia, it important understand its regulation. Here, we demonstrate direct role ciliary protein UNC119 trafficking...
Malfunctions in the basic epigenetic mechanisms such as histone modifications, DNA methylation, and chromatin remodeling are implicated a number of cancers immunological neurodegenerative conditions. Within GlaxoSmithKline (GSK) we have utilized variations NanoBRET technology for direct measurement compound-target engagement within native cellular environments to drive high-throughput, routine structure-activity relationship (SAR) profiling across differing targets. is variation...
Summary The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in cancer genome, with truncating mutations respiratory complex I genes being over-represented 1 . While DNA (mtDNA) have been associated both improved worsened prognoses several tumour lineages 1–,3 , whether these are drivers or exert any functional effect on biology remains controversial. Here we discovered that...