A5025080104- Parasites and Host Interactions
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Vector-Borne Animal Diseases
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Virus-based gene therapy research
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- Advanced Proteomics Techniques and Applications
- Parasitic infections in humans and animals
- RNA and protein synthesis mechanisms
- Pancreatic and Hepatic Oncology Research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Virology and Viral Diseases
Cancer Research UK
2024
Cancer Research UK Scotland Institute
2022-2023
University of Glasgow
2019-2022
Wellcome Centre for Molecular Parasitology
2021-2022
AstraZeneca (United Kingdom)
2020
The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically mutated regions of cancer genome, but whether these mutations impact tumor biology debated. We engineered truncating mtDNA-encoded complex I gene, Mt-Nd5, into several murine models melanoma. These promoted a Warburg-like shift that reshaped microenvironments in both mice humans, consistently eliciting an anti-tumor immune response...
Oncolytic virus (OV) therapy is an emerging approach with the potential to redefine treatment options across a range of cancer indications and in patients who remain resistant existing standards care, including immuno-oncology (IO) drugs. MEDI5395, recombinant Newcastle disease (NDV), engineered express granulocyte-macrophage colony-stimulating factor (GM-CSF), exhibits potent oncolytic activity. It was hypothesized that activation immune cells by coupled its activity, would enhance priming...
T cell responses against infections and cancer are directed by conventional dendritic cells (cDCs) in lymph nodes distant from the site of challenge. Migratory cDCs, which travel tissue to node, not only drive initial activation but also transfer antigen node–resident cDCs. These resident have essential roles defining character resulting response; however, it is unknown how they can appropriately process present antigens suitably direct given their spatial separation. Here, using a novel...
Type 2 immunity is activated in response to both allergens and helminth infection. It can be detrimental or beneficial, there a pressing need better understand its regulation. The immunosuppressive cytokine IL-10 known as T helper (Th2) effector molecule, but it currently unclear whether dampens promotes Th2 differentiation during Here we show that infection mice elicits expression the intestinal lamina propria draining mesenteric lymph node, with higher infected tissue. In vitro, exogenous...
The use of helminth infections as tools to understand the type 2 immune response is a well-established technique and important many areas immunological research. phenotype function cell populations at site infection key determinant pathogen clearance. However, with helminths such murine nematode Heligomosmoides polygryrus cause increased mucus production thickening intestinal wall, which can result in extensive death when isolating analysing cells from lamina propria (LP). Populations larger...
Summary The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in cancer genome, with truncating mutations respiratory complex I genes being over-represented 1 . While DNA (mtDNA) have been associated both improved worsened prognoses several tumour lineages 1–,3 , whether these are drivers or exert any functional effect on biology remains controversial. Here we discovered that...
Type 2 immunity is activated in response to both allergens and helminth infection. It can be detrimental or beneficial, there a pressing need better understand its regulation. The immunosuppressive cytokine IL-10 known as T helper (Th2) effector molecule, but it currently unclear whether dampens promotes Th2 differentiation during Here we show that infection mice elicits expression the intestinal lamina propria draining mesenteric lymph node, with higher infected tissue. In vitro, exogenous...
Abstract The use of helminth infections as tools to understand the type 2 immune response is a well-established technique and important many areas immunological research. phenotype function cell populations at site infection key determinant pathogen clearance. However, with helminths such murine nematode Heligomosmoides polygryrus cause increased mucus production thickening intestinal wall, which can result in extensive death when isolating analysing cells from lamina propria (LP)....