A5041551133- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- Antimicrobial Peptides and Activities
- Animal Genetics and Reproduction
- Biochemical and Molecular Research
- Monoclonal and Polyclonal Antibodies Research
- Digestive system and related health
- Bacterial Genetics and Biotechnology
- interferon and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- Cytomegalovirus and herpesvirus research
- Prion Diseases and Protein Misfolding
- Synthesis and Reactivity of Heterocycles
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
Yale University
2017-2023
Taipei Veterans General Hospital
2019
University of Connecticut
2017
Institute of Cellular and Organismic Biology, Academia Sinica
2006
Academia Sinica
2003-2004
Institute of Zoology
2003-2004
Single-cell transcriptome analysis by HIV-1 SortSeq identifies HIV-1–driven aberrant host gene transcription as a mechanism of persistence.
Despite effective antiretroviral therapy, HIV-1–infected cells continue to produce viral antigens and induce chronic immune exhaustion. We propose identify HIV-1–suppressing agents that can inhibit HIV-1 reactivation reduce HIV-1–induced activation. Using a newly developed dual-reporter system high-throughput drug screen, we identified FDA-approved drugs suppress in both cell line models CD4+ T from virally suppressed individuals. 11 cellular pathways required for as druggable targets....
Abstract Liver fatty acid binding protein (L‐FABP) is a small that thought to play an important role in the intracellular and trafficking of long chain acids liver. Expression gene encoding zebrafish liver regulated by 435‐bp distal region (−1944 −1510) L‐FABP promoter. The sequence sufficient for activation primordia (or bud) continues be active adult when positioned adjacent SV40 basal promoter linked directly green fluorescent protein. has two distinct regulatory elements, A −1623) B...
Micro-nano plastics originating from the prevalent usage of have raised increasingly alarming concerns worldwide. However, there remains a fundamental knowledge gap in nanoplastics because lack effective analytical ...Plastics are now omnipresent our daily lives. The existence microplastics (1 µm to 5 mm length) and possibly even (<1 μm) has recently health concerns. In particular, believed be more toxic since their ...
HIV-1-infected cells, which can survive drug treatment and immune cell killing, prevent an HIV-1 cure. Immune recognition of infected cells requires protein expression; however, expression is limited in after long-term therapy.
HIV transcription requires assembly of cellular factors at the HIV-1promoter. The TFIIH general factor facilitates initiation by opening DNA strands around start site and phosphorylating C-terminal domain for RNA polymerase II (RNAPII) activation. Spironolactone (SP), an FDA approved aldosterone antagonist, triggers proteasomal degradation XPB subunit TFIIH, concurrently suppresses acute infection in vitro Here we investigated SP as a possible block-and-lock agent functional cure aimed...
Abstract Intestinal‐type fatty acid binding protein (I‐FABP) plays an important role in the intracellular and trafficking of long chain acids intestine. The aim this study, therefore, was to elucidate regulation spatiotemporal expression I‐FABP gene during zebrafish larval development. We performed vivo reporter‐gene analysis by using a transient transgenic approach. Green fluorescent protein–reporter analyses revealed that proximal 192‐bp region promoter is sufficient direct...
Significance Circular SPHINX DNAs with significant homology to segments of Acinetobacter phage viruses were previously isolated from cytoplasmic particles in mammalian cells and brain. are widespread opportunistic pathogens, permanent transfer prokaryotic mammals has not been reported. To find whether 324-aa ORF is translated into its cognate protein (spx1), an antibody was raised against internal peptide no any known cellular or viral sequences. Western blots brains (rodent human) displayed...
HIV-1 reverse transcriptase (RT) remains a key target for HIV drug development. As successful management of the disease requires lifelong treatment, emergence resistance mutations is inevitable, making development new RT inhibitors, which remain effective against resistant variants crucial. To this end, previous computationally guided design efforts have resulted in catechol diether compounds, inhibit wildtype with picomolar affinities and appear to be promising preclinical candidates....