A5067780553- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
Amsterdam University Medical Centers
2023-2024
Netherlands Institute for Neuroscience
2021-2023
University of Amsterdam
2021-2023
Royal Netherlands Academy of Arts and Sciences
2023
Amsterdam Neuroscience
2023
Early-life stress (ELS) leads to increased vulnerability psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated ELS-induced negative health outcomes, but how ELS impacts microglia, the main tissue-resident macrophages of central nervous system, is unknown. Here, we determined effects by limited bedding and nesting material during first week life (postnatal days [P]2-9) on microglial (i) morphology; (ii) hippocampal gene expression; (iii)...
Exposure to early-life stress (ES) increases the risk develop obesity later in life, and these effects may be sex-specific, but it is currently unknown what underlies ES-induced metabolic vulnerability. We have previously shown that ES leads a leaner phenotype under standard chow diet conditions, increased fat accumulation when exposed an unhealthy obesogenic diet. However diets were fed without choice. An important, yet investigated, element contributing development of humans choice food....
Growing evidence demonstrates the role of striatal dopamine system in regulation glucose metabolism. Treatment with antagonists is associated insulin resistance and hyperglycemia, while agonists are used treatment type 2 diabetes. The mechanism underlying effects metabolism, however not fully understood. Here, we provide mechanistic insights into nucleus accumbens shell (sNAc) dopaminergic signaling systemic metabolism.Endogenous production (EGP), blood mRNA expression lateral hypothalamic...
Abstract The lateral habenula (LHb), a small epithalamic nucleus, modifies downstream midbrain dopamine neuron output to regulate negative state and aversion. Furthermore, specific glutamatergic input, from, among others, the hypothalamus central amygdala LHb modulates consumption of (palatable) diet components. However, it is currently unclear if blockade all input sufficient alter eating behavior. Here, we used pharmacological approach inhibit by bilateral infusion either an AMPA/kainate...
Abstract Early-life stress (ELS) leads to increased vulnerability psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated ELS-induced negative health outcomes, but how ELS impacts microglia, the main tissue-resident macrophages of central nervous system, is unknown. Here, we determined effects induced by limited bedding and nesting material during first week life (postnatal days [P]2 – 9) on microglial i) morphology; ii) hippocampal gene...