A5015945171- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Cardiovascular Syncope and Autonomic Disorders
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Radiomics and Machine Learning in Medical Imaging
- Chromosomal and Genetic Variations
- Healthcare cost, quality, practices
- CRISPR and Genetic Engineering
- Phonocardiography and Auscultation Techniques
- Cardiovascular Effects of Exercise
- RNA modifications and cancer
- Health disparities and outcomes
- Genomics and Phylogenetic Studies
- Autopsy Techniques and Outcomes
- Suicide and Self-Harm Studies
- Inflammation biomarkers and pathways
- COVID-19 diagnosis using AI
- Chronic Obstructive Pulmonary Disease (COPD) Research
University of California, San Francisco
2020-2022
Brown University
2016
Abstract In gonadal tissues, the Piwi-interacting (piRNA) pathway preserves genomic integrity by employing 23–29 nucleotide (nt) small RNAs complexed with argonaute proteins to suppress parasitic mobile sequences of DNA called transposable elements (TEs). Although recent evidence suggests that piRNA may be present in select somatic cells outside gonads, role a non-gonadal is not well characterized. Here we report functional adult Drosophila fat body including presence effector protein Piwi...
Abstract The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results comparative lower tract transcriptional profiling tracheal aspirate 52 critically ill patients with COVID-19 or etiologies, as well controls without ARDS. In contrast to a “cytokine storm,” observe reduced proinflammatory gene expression in when compared due causes. is characterized by...
Resolution of the acute respiratory distress syndrome (ARDS) from pneumonia requires repair injured lung endothelium and alveolar epithelium, removal neutrophils distal airspaces lung, clearance pathogen. Previous studies have demonstrated importance specialized proresolving mediators (SPMs) in regulation host responses during inflammation. Although ARDS is commonly caused by Streptococcus pneumoniae, role lipoxin A4 (LXA4) resolvin D1 (RvD1) pneumococcal not well understood. In present...
Abstract Background The ventilatory ratio (VR, [minute ventilation × PaCO 2 ]/[predicted body weight 100 37.5]) is associated with mortality in ARDS. aims of this study were to test whether baseline disease severity or neuromuscular blockade (NMB) modified the relationship between VR and mortality. Methods This was a post hoc analysis PETAL-ROSE trial, which randomized moderate-to-severe ARDS patients NMB control. Survival among different trajectories cutoff above below median assessed by...
<h3>BACKGROUND:</h3> How indices specific to respiratory compromise contribute prognostication in patients with ARDS is not well characterized general clinical populations. The primary objective of this study was identify variables failure that might add prognostic value indicators systemic illness severity an observational cohort subjects ARDS. <h3>METHODS:</h3> Fifty were enrolled a single-center, prospective, cohort. We tested the contribution (oxygenation index, ventilatory ratio [VR],...
This case report describes a person in their 70s found unconscious and unresponsive who had history of hypertension, dyslipidemia, atrial fibrillation, seizure disorder, coronary artery disease an implantable loop recorder placed 6 months prior.
Abstract Background Two molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified. Classification as “hyperinflammatory” or “hypoinflammatory” depends on plasma biomarker profiling. Differences in pulmonary biology underlying these are unknown. Methods We analyzed tracheal aspirate (TA) RNA sequencing (RNASeq) data from 41 ARDS patients 5 mechanically ventilated controls assess differences lung...
Abstract We performed comparative lower respiratory tract transcriptional profiling of 52 critically ill patients with ARDS from COVID-19 or other etiologies, without ARDS. found no evidence cytokine storm but instead observed complex host response dysregulation driven by genes non-canonical roles in inflammation and immunity that were predicted to be modulated dexamethasone. Compared viral ARDS, was characterized impaired interferon-stimulated gene expression.
Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a rapid increase in the incidence of acute respiratory distress syndrome (ARDS). distinct features pulmonary biology COVID-19 ARDS compared other causes ARDS, including lower tract infections (LRTIs), are not well understood. Methods: Tracheal aspirates (TA) and plasma were collected within five days intubation from mechanically ventilated adults admitted one two academic medical centers. LRTI diagnoses verified by study...
Introduction: Prior studies report higher cardiovascular mortality in persons experiencing homelessness (PEH), but presume cardiac cause of death (COD) from EMS records or certificates. The effect on autopsy-defined SCD is unknown. In this prospective postmortem study all SCDs San Francisco (SF) County, we hypothesized a greater incidence presumed PEH, more non-cardiac COD autopsy. Methods: Between 2/2011 - 3/2014, incident World Health Organization-defined (presumed) ages 18-90 were...
Abstract Background Estimating mortality risk is essential for prognostic enrichment. How various indices specific to respiratory compromise contribute prognostication in patients with acute distress syndrome (ARDS) not well-characterized general clinical populations. The primary objective of this study was identify variables failure that add value indicators systemic illness severity. We tested the added benefit a representative observational cohort ARDS. Methods 50 ARDS were enrolled...