Chayse Jones
A5072741865- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Immune Response and Inflammation
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Advances in Oncology and Radiotherapy
- Radiation Dose and Imaging
- COVID-19 Impact on Reproduction
- Abdominal Trauma and Injuries
- Palliative Care and End-of-Life Issues
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Hepatitis C virus research
- Delphi Technique in Research
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Musculoskeletal Disorders and Rehabilitation
- Healthcare cost, quality, practices
- Intensive Care Unit Cognitive Disorders
- Trauma and Emergency Care Studies
University of California, San Francisco
2021-2024
University of California System
2021-2024
Advanced ENT and Allergy
2024
Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics
2022
Royal Australasian College of Physicians
2011
Children's Hospital at Westmead
2011
Instituto de Salud Carlos III
2006
Allegheny General Hospital
2000
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals1-3, many others experience milder symptoms. Here, to gain a more comprehensive understanding of the distinction between mild phenotypes pathology disease 2019 (COVID-19) its origins, we performed whole-blood-preserving single-cell analysis protocol integrate contributions from all major immune cell types blood-including neutrophils, monocytes,...
Abstract The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results comparative lower tract transcriptional profiling tracheal aspirate 52 critically ill patients with COVID-19 or etiologies, as well controls without ARDS. In contrast to a “cytokine storm,” observe reduced proinflammatory gene expression in when compared due causes. is characterized by...
Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)-associated acute respiratory distress syndrome. However, the effects of COVID-19 on lung endothelium are not well defined. We hypothesized is caused by circulating host factors direct endothelial infection severe syndrome 2 (SARS-CoV-2). Objectives: aimed determine SARS-CoV-2 or sera from patients with permeability inflammatory activation microvascular cells. Methods: Human...
Two molecular phenotypes have been identified in acute respiratory distress syndrome (ARDS). In the ROSE (Reevaluation of Systemic Early Neuromuscular Blockade) trial cisatracurium moderate to severe ARDS, we addressed three unanswered questions:
Abstract Background Studies quantifying SARS-CoV-2 have focused on upper respiratory tract or plasma viral RNA with inconsistent association clinical outcomes. The between antigen levels and outcomes has not been previously studied. Our aim was to investigate the relationship nucleocapsid (N-antigen) concentration both markers of host response Methods N-antigen concentrations were measured in first study sample (D0), collected within 72 h hospital admission, from 256 subjects admitted March...
Abstract Background Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation mechanical ventilation. Detailed clinical and biological features RIARDS have not been clearly defined, it unknown whether associated with the hypoinflammatory or hyperinflammatory phenotype ARDS. The purpose this study was to define its association inflammatory subphenotypes. Methods We analyzed data from...
Abstract Dexamethasone is the standard of care for critically ill patients with COVID-19, but mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk single-cell RNA sequencing samples from lower respiratory tract blood, assess plasma cytokine profiling to study dexamethasone on both systemic pulmonary immune cell compartments. In blood samples, associated decreased expression genes T activation, including TNFSFR4...
There remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue impact hospital systems. We sought characterize association receptor advanced glycation end products (RAGE), SARS-CoV-2 nucleocapsid viral antigen, and panel thromboinflammatory biomarkers with development disease in presenting emergency department symptomatic COVID-19.
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway blood cells from patients with acute lung injury SARS-CoV-2 or other causes across 7 cohorts. This was associated greater clinical severity predicted future mechanical ventilation death.
The soluble receptor for advanced glycation end-products (sRAGE) is a marker of alveolar type I cell injury associated with outcomes in COVID-19 pneumonia. How plasma sRAGE changes over time and whether it remains long-term clinical beyond single measurement have not been well studied. We studied two cohorts randomized trials monoclonal antibody treatment (bamlanivimab tixagevimab/cilgavimab). first the association between baseline 90-day outcomes, which had previously demonstrated...
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disorder characterized by severe arrhythmias and heart dysfunction. Mutations in desmosome gene Plakophilin-2 ( PKP2 ) account for 40% of ARVC cases, with current palliative therapies failing to address the cause. Herein, we generated an vitro model using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) harboring pathogenic variant (c.2146G>C), as platform test -gene replacement...
Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated for COVID-19, we comparatively assess longitudinal airway microbiome dynamics and the pulmonary transcriptome patients who developed 2°BP versus controls did not. We find that significantly both mortality corticosteroid treatment. The in characterized by increased RNA mass...
Thromboinflammatory complications are well described sequalae of Coronavirus Disease 2019 (COVID-19), and there is evidence both hyperreactive platelet inflammatory neutrophil biology that contributes to the thromoinflammatory milieu. It has been demonstrated in other thromboinflammatory diseases circulating environment may affect cellular behavior, but what role this exerts on platelets neutrophils COVID-19 remains unknown. We tested hypotheses 1) plasma from patients can induce a...
This paper reports on work undertaken to achieve an application for monies from the European Commission's 6th Framework Programme by some key stakeholders, working with a nursing and midwifery research agenda at national policy levels.A short outline of Research Area Network scheme is given in order set context, vision underpinning discussed.The describes processes that were bring fruition such collaborative work, lessons are outlined. Seeking opportunities enhance within context gives value...
Introduction: Of the 2.6 million annual pediatric infectious deaths, 2/3 occur in sub-Saharan Africa and majority are preventable. Life-threatening infections present as severe febrile illness; rapid diagnosis, early treatment, identification of those at risk deterioration can significantly improve survival. Biomarkers distinguish from mild disease have been used to risk-stratify acutely ill children. We hypothesized that inflammatory biomarkers could predict clinical Tanzanian children...
Interferon alfacon-1 (Infergen®) 15 mcg in the treatment of naive chronic hepatitis C patients, three vs. five times a week
I am glad that the case of au pair Louise Woodward received so much attention here and in US.