A5056969757- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Olfactory and Sensory Function Studies
- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Motor Control and Adaptation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Complementary and Alternative Medicine Studies
- Medical and Biological Ozone Research
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Cerebral Venous Sinus Thrombosis
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Restless Legs Syndrome Research
- Salivary Gland Disorders and Functions
- Psychosomatic Disorders and Their Treatments
- Moyamoya disease diagnosis and treatment
- Gut microbiota and health
- Sleep and Wakefulness Research
- Hydrogen's biological and therapeutic effects
- Cerebrovascular and genetic disorders
Gazi University
2015-2025
Giresun University
2024
Massachusetts General Hospital
2022
Harvard University
2022
Gazi Hastanesi
2021
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2019
Medication overuse headache (MOH) was recently shown to be associated with leaky gut in rodents. We aimed investigate whether chronic migraine (CM) patients MOH have elevated lipopolysaccharide levels and inflammatory molecules blood circulation.
Medication overuse is common among chronic migraine patients and nonsteroidal antiinflammatory drugs (NSAIDs)are the most frequently overused drugs. The pathophysiological mechanisms underlying medication headache (MOH) are notcompletely understood. Intestinal hyperpermeability leaky gut reported in using NSAIDs. aim of study toinvestigate role inflammation an MOH model male rats.Methods: was conducted Sprague Dawley rats. There were two experimental groups. first group chronicNSAID which...
Background and objective Somatosensory temporal discrimination was recently reported as prolonged during migraine attacks, which is consistent with disrupted sensorial perception in migraine. However, knowledge about central sensory processing tension-type headache still lacking. This prospective, controlled study aimed to investigate somatosensory thresholds headache. Methods The included 10 patients, patients healthy volunteers without were evaluated the attacks of patients. Results (39.0...
Chronic migraine (CM) patients with medication overuse headache (MOH) were recently shown to be associated leaky gut and inflammation. We aimed investigate microbiota profiles of CM MOH, their correlations inflammatory serum parameters, food triggers, comorbid anxiety depression.
Vestibular migraine (VM) is one of the most common underdiagnosed disorders. We aimed to study clinical characteristics VM patients who were referred a neurology-headache unit by otolaryngology after exclusion peripheral causes vertigo. One hundred and diagnosed with in headache included. Description vestibular symptoms, demographic features, trigger factors, accompanying diseases, response vestibular-suppressant medications prophylactic treatment evaluated. symptoms triggered daily head...
Migraine headache attacks have been shown to be accompanied by significant prolongation of somatosensory temporal discrimination threshold values, supporting signs disrupted sensorial processing in migraine. Chronic migraine is one the most debilitating and challenging disorders with no available biomarker. We aimed test diagnostic value for chronic this prospective, controlled study.Fifteen patients 15 healthy controls completed study. were evaluated twice, during a headache-free period....
Abstract Background/aim Certain constituents in migraine food triggers and non-steroidal anti-inflammatory drugs (NSAIDs) inhibit sulfotransferases (SULTs) that detoxify drugs/chemicals play role the metabolism of neurotransmitters. We aimed to dissect SULT1A1 modulation CSD susceptibility behavior an vivo experimental model using hesperidin, a inhibitor found citrus fruits (known triggers) mefenamic acid (SULT1A1 inhibitor), NSAID simulate medication overuse. Methods Hesperidin was used as...
Irritable bowel syndrome (IBS) is an under-diagnosed common health problem that impairs quality of life. Migraine and IBS are comorbid disorders triggered by foods. We aim to investigate frequency in medication overuse headache (MOH) patients identify food triggers avoidance behavior.
Abstract Objective Medication overuse headache (MOH) is a secondary that accompanies chronic migraine. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently used analgesics worldwide and they known to induce leaky gut. In this study, we aimed investigate whether NSAID induced MOH associated with altered circulating lipopolysaccharide binding protein (LBP) levels inflammatory molecules. Materials methods Piroxicam (10 mg/kg/day, po) for 5 weeks was in female Sprague Dawley...
Abstract Background and Objective Migraine attacks disrupt sensory information processing may also disturb sensorimotor integration. This prospective pilot study aimed to assess the integration inhibitory circuitry in cortex using short‐latency afferent inhibition (SAI) paradigm migraine. Methods Twenty‐five migraine without aura patients (10 interictal, 5 preictal, 10 ictal) 16 healthy controls were enrolled. SAI was elicited by combining right median nerve electrical stimulation left motor...
Metoclopramide is an effective and commonly used medication in acute migraine treatment but experimental evidence base lacking. We aimed to investigate the antimigraine effect of metoclopramide a model whether analgesic was likely be D2 receptor-mediated.Cortical spreading depression (CSD) adult male Wistar rats. Five CSDs were induced by pinprick. (two different doses), raclopride, or 0.9% saline administered 30 min before CSD induction. Two hours after experiments, brain tissues examined...
Introduction: Experimental animal studies have revealed mechanisms that link cortical spreading depression (CSD) to the trigeminal activation mediating lateralized headache. However, conventional CSD as seen in lissencephalic brain is insufficient explain some clinical features of aura and migraine headache.Areas covered: The importance headache development including dysfunction thalamocortical network, neuroinflammation, calcitonin gene-related peptide, transgenic models, role triggers,...
Background/Aim: Chronification of migraine is a serious health problem with difficulties in management and related to increased disability. Inflammation suggested have role its chronification. We aimed determine whether systemic inflammatory response tested by serum interleukin-6 (IL-6) levels obesity were attack frequency. Methods: A total 40 female participants (20 chronic migraine, 10 episodic healthy controls without headache) included the study. None patients on prophylaxis. Episodic...