A5115076552- Chemokine receptors and signaling
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Lymphatic System and Diseases
- Veterinary Oncology Research
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Proteoglycans and glycosaminoglycans research
- Cancer Research and Treatments
- Receptor Mechanisms and Signaling
- Axon Guidance and Neuronal Signaling
- Lymphatic Disorders and Treatments
- Asthma and respiratory diseases
- Galectins and Cancer Biology
- Natural product bioactivities and synthesis
- Chemotherapy-induced cardiotoxicity and mitigation
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
Tohoku University
2018-2025
China Pharmaceutical University
2022-2024
Xinxiang Medical University
2024
Guangzhou Medical University
2019-2024
Pharmac
2022
Nanjing Normal University
2021
Tohoku Fukushi University
2019
Shokei Gakuin University
2019
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein, which highly expressed on tumor cells. As EpCAM plays crucial role in adhesion, survival, proliferation, stemness, and tumorigenesis, it has been considered as promising target for diagnosis therapy. Anti‑EpCAM monoclonal antibodies (mAbs) have developed previously demonstrated outcomes several clinical trials. An anti‑EpCAM mAb, EpMab‑37 (mouse IgG<sub>1</sub>, kappa) was by the authors, using cell‑based...
CC chemokine receptor 3 (CCR3) belongs to the G protein-coupled family and is highly expressed in eosinophils basophils. CCR3 essential for recruiting into lung. Moreover, was found serum of colorectal cancer patients higher than control group. Therefore, will be a useful target asthma diagnosis. This study developed specific sensitive monoclonal antibody (mAb) mouse (mCCR3), which flow cytometry using Cell-Based Immunization Screening method. The established anti-mCCR3 mAb, C3Mab-3 (rat...
C-C chemokine receptor 5 (CCR5), a member of the G protein-coupled family, is most common coreceptor for human immunodeficiency virus type 1. CCR5 also involved in pathogenesis tumors and inflammatory diseases. The antagonists including monoclonal antibodies (mAbs) have been developed evaluated clinical trials. In this study, we novel mAbs mouse (mCCR5) using Cell-Based Immunization Screening (CBIS) method. One established anti-mCCR5 mAbs, C
CD44 is a type I transmembrane glycoprotein associated with poor prognosis in various solid tumors. Since plays critical role tumor development by regulating cell adhesion, survival, proliferation and stemness, it has been considered target for therapy. Anti‑CD44 monoclonal antibodies (mAbs) have developed applied to antibody‑drug conjugates chimeric antigen receptor‑T Anti-pan‑CD44 mAbs, C<sub>44</sub>Mab‑5 C<sub>44</sub>Mab‑46, which recognize both standard (CD44s) variant isoforms were...
Glypican 5 (GPC5) is a member of heparan sulfate proteoglycans and anchored to the plasma membrane via glycosylphosphatidylinositol. GPC5 plays an essential role in kidney, limb, brain development. Furthermore, expressed some cancers, but whether it functions as cancer-promoting or -suppressing factor remains unclear. Therefore, development versatile specific anti-GPC5 antibodies desired clarify biological pathological GPC5. In this study, we successfully established anti-human monoclonal...
Podoplanin (PDPN) is a type I transmembrane protein with highly glycosylated extracellular domain, and short intracellular domain. PDPN expression observed in normal tissue cells, including lung alveolar epithelial kidney podocytes, lymphatic endothelial cells. Therefore, anti-PDPN monoclonal antibodies (mAbs) various animal species helped to identify PDPN-positive cells.We have developed mAbs more than 20 species. These are applicable flow cytometry, western blot, immunohistochemistry. In...
Erythropoietin-producing hepatocellular receptor A1 (EphA1) is one of the Eph family members, largest group tyrosine kinases. EphA1 expressed in various tissues and regulates cellular homeostasis by interacting with its membrane-bound ephrin ligands other receptors. critically correlates pathogenesis several disorders, including Alzheimer’s disease cancers. Therefore, establishing sensitive monoclonal antibodies (mAbs) for has been desired basic research, diagnosis, treatment. In this study,...
The epithelial cell adhesion molecule (EpCAM) is a surface glycoprotein, which widely expressed on normal and cancer cells. EpCAM involved in adhesion, proliferation, survival, stemness, tumorigenesis. Therefore, thought to be promising target for diagnosis therapy. In this study, we established anti-EpCAM monoclonal antibodies (mAbs) using the Cell-Based Immunization Screening (CBIS) method. We characterized them flow cytometry, Western blotting, immunohistochemistry. One of recombinant...
The CC chemokine receptor type-2 (CCR2) belongs to the G-protein-coupled superfamily, expressed on cell surface of immune cells and tumors. CCR2 binds motif 2/monocyte chemoattractant protein-1, a chemokine, which is produced by various cells, including immune-related Therefore, development sensitive monoclonal antibodies (mAbs) for has been desired treatment diagnosis. This study established novel, specific, anti-mouse (mCCR2) mAb; C2Mab-6 (rat IgG1, kappa), using mCCR2 synthetic peptide...
The epithelial cell adhesion molecule (EpCAM) is a stem and carcinoma antigen, which mediates cellular proliferative signaling by the proteolytic cleavage. In contrast to low expression in normal epithelium, EpCAM frequently overexpressed various carcinomas, correlates with poor prognosis. Therefore, has been considered as promising target for tumor diagnosis therapy. Using Cell-Based Immunization Screening (CBIS) method, we previously established an anti-EpCAM monoclonal antibody (EpMab-37;...
The CXC chemokine receptor 6 (CXCR6) is a member of the G protein-coupled family that highly expressed in helper T type 1 cells, cytotoxic lymphocytes (CTLs), and natural killer cells. CXCR6 plays critical roles local expansion effector-like CTLs tumor microenvironment to potentiate antitumor response. Therefore, development anti-CXCR6 monoclonal antibodies (mAbs) essential evaluate immune tumors. Using N-terminal peptide immunization, we previously developed an anti-mouse (mCXCR6) mAb,...
The C-X-C motif chemokine receptor-1 (CXCR1) is a rhodopsin-like G-protein-coupled receptor, expressed on the cell surface of immune cells and tumors. CXCR1 interacts with some chemokines, such as CXCL6, CXCL7, CXCL8/interleukin-8, which are produced by various cells. Since involved in several diseases including tumors diabetes mellitus, drugs targeting have been developed. Therefore, development sensitive monoclonal antibodies (mAbs) for has desired diagnosis treatment. This study...
One of the G protein-coupled receptors, C-C chemokine receptor 5 (CCR5), is an important regulator for activation T and B lymphocytes, dendritic cells, natural killer macrophages. Upon binding to its ligands, CCR5 activates downstream signaling, which in innate adaptive immune response through promotion lymphocyte migration secretion proinflammatory cytokines. Anti-CCR5 monoclonal antibodies (mAbs) have been developed evaluated clinical trials tumors inflammatory diseases. In this study, we...
The C-C motif chemokine receptor 3 (CCR3) is a G protein-coupled activated by eotaxin-1-3, MCP-2-4, and RANTES. CCR3 associated with allergic diseases cancer development highly expressed in eosinophils, basophils, cells. Besides, research on the physiological roles of ongoing. Thus, specific monoclonal antibodies (mAbs) for would be useful diagnostic therapeutic purposes unraveling function CCR3. We previously developed an anti-mouse (mCCR3) mAb (C3Mab-2; rat IgG2b, kappa) using Cell-Based...
C-C motif chemokine receptor 8 (CCR8) is a G protein-coupled predominantly expressed in regulatory T (Treg) and helper 2 cells. The evidence that CCR8 expression Treg increased cancers, increases migration activity of Treg, induces the anti-apoptotic cell leukemia lymphoma suggests associated with cancer development. Thus, developing specific monoclonal antibody (mAb) for useful diagnostic therapeutic purposes anti-CCR8 mAb becomes remarkable experimental tool basic research. We previously...
Golden (Syrian) hamster (Mesocricetus auratus) is a small animal model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Pathological analyses the tissues are required to understand pathogenesis SARS-CoV-2 and evaluation therapeutic modalities, including neutralizing monoclonal antibodies (mAbs). However, mAbs that recognize golden hamster-derived antigens distinguish specific cell types, such as pneumocytes, limited. Podoplanin (PDPN) an essential marker lung type...
CD44 regulates cell adhesion, proliferation, survival, and stemness has been considered a tumor therapy target. possesses the shortest standard (CD44s) variety of variant (CD44v) isoforms. Since expression CD44v is restricted in epithelial cells carcinomas compared to CD44s, promising target for monoclonal antibody (mAb) therapy. We previously developed an anti-CD44v10 mAb, C
The CC chemokine receptor 3 (CCR3) is a for chemokines, including CCL5/RANTES, CCL7/MCP-3, and CCL11/eotaxin. CCR3 expressed on the surface of eosinophils, basophils, subset Th2 lymphocytes, mast cells, airway epithelial cells. its ligands are involved in hyperresponsiveness allergic asthma, ocular allergies, cancers. Therefore, an attractive target those therapies. Previously, anti-mouse (mCCR3) monoclonal antibodies (mAbs), C3Mab-3 (rat IgG2a, kappa), C3Mab-4 kappa) were developed using...
One of G protein-coupled receptors, CCR9, is mainly expressed in the thymocytes and small bowel. The ligand CCR9 CCL25 (TECK), CCR9-CCL25 axis controls T cell maturation intestinal immune response. related to graft-versus-host disease autoimmune diseases. Recent studies have been reported that also associated with tumor proliferation, apoptosis, migration, drug resistance. Therefore, CCR9-targeting therapy receiving a lot attention. Previously, we developed an anti-human (hCCR9) monoclonal...
BACKGROUND Thyroid cancer causes considerable mortality and morbidity across the globe. Owing to unavailability of biomarkers adverse effects existing drugs, there is an urgent need develop efficient chemotherapy for treatment thyroid cancers. Plants have served as exceptional source drugs lethal diseases. The purpose this study was evaluate anticancer ferruginol against cells. MATERIAL AND METHODS We monitored cell proliferation rate using...