A5101437010- Glioma Diagnosis and Treatment
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Gastrointestinal disorders and treatments
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Caveolin-1 and cellular processes
- Alzheimer's disease research and treatments
- Cellular Mechanics and Interactions
- Cell Image Analysis Techniques
- Inertial Sensor and Navigation
- Animal Vocal Communication and Behavior
- Neurological disorders and treatments
- Neuroblastoma Research and Treatments
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Nanoparticle-Based Drug Delivery
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Advanced Breast Cancer Therapies
- Insect Pest Control Strategies
- Genetic factors in colorectal cancer
- Axon Guidance and Neuronal Signaling
University of Auckland
2016-2025
Florida College
2023
University of Florida
2020-2023
University of Illinois Chicago
2011-2023
Brain Research New Zealand
2018-2020
Jacobs (United States)
2018-2020
University of Virginia
2019
Pharmac
2016-2018
MedTech CoRE
2018
Marshall Space Flight Center
2018
Allee, W. C., Alfred E. Emerson, Orlando Park, Thomas and Karl P. Schmidt. Principles of Animal Ecology. Philadelphia London: B. Saunders Company. xii + 837 pp., 263 figs. 1949. $14.00 Get access Allee C. Emerson Park Schmidt P.. $14.00. Dana Paul Snyder Search for other works by this author on: Oxford Academic Google Scholar Journal Mammalogy, Volume 31, Issue 3, August 1950, Pages 365–367, https://doi.org/10.2307/1375307 Published: 01 1950
Transforming growth factor beta 1 (TGFβ1) is strongly induced following brain injury and polarises microglia to an anti-inflammatory phenotype. Augmentation of TGFβ1 responses may therefore be beneficial in preventing inflammation neurological disorders including stroke neurodegenerative diseases. However, several other cell types display immunogenic potential identifying the effect on these cells required more fully understand its effects inflammation. Pericytes are multifunctional which...
Abstract Parkinson’s disease (PD) is characterized by the presence of inclusions known as Lewy bodies, which mainly consist α-synuclein (α-syn) aggregates. There growing evidence that α-syn self-propagates in non-neuronal cells, thereby contributing to progression and spread PD pathology brain. Tunneling nanotubes (TNTs) are long, thin, F-actin-based membranous channels connect cells have been proposed act conduits for transfer between cells. SH-SY5Y primary human brain pericytes, derived...
Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding molecular events underpinning microglial functions activation states will further enable us to target these cells for treatment of neurological disorders. The transcription factor PU.1 is development myeloid a major regulator gene expression. In brain, specifically expressed microglia recent evidence from genome-wide association studies suggests that reductions contribute delayed onset...
Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) play an important role in neuroinflammation. To date, majority inflammation-related studies endothelia pericytes have been carried out using immortalised cell lines or non-human-derived cells. Whether these representative primary human is unclear systematic comparisons inflammatory responses brain-derived has yet to be performed.To study effects neuroinflammation at BBB, brain were isolated from...
Abstract Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment pericyte loss Alzheimer’s disease (AD) well documented. We found that PDGF-BB:PDGFRβ components were altered human AD brains, with marked reduction vascular PDGFB . hypothesised reduced may impact on BBB. therefore tested effects PDGF-BB primary vitro define...
Abstract Microglia, the resident macrophages of central nervous system play vital roles in brain homeostasis through clearance pathogenic material. Microglia are also implicated neurological disorders uncontrolled activation and inflammatory responses. To date, vast majority microglial studies have been performed using rodent models. Human microglia differ from counterparts several aspects including their response to pharmacological substances secretions. Such differences highlight need for...
Abstract Neuroinflammation contributes to the pathogenesis of several neurological disorders and pericytes are implicated in brain inflammatory processes. Cellular responses orchestrated by transcription factors but information on transcriptional control is lacking. Because factor CCAAT/enhancer binding protein delta (C/EBPδ) induced a number disorders, we sought investigate its role regulating pericyte immune responses. Our results reveal that C/EBPδ concentration- time-dependent fashion...
Abstract Background Microglia and tumor-associated macrophages (TAMs) constitute up to half of the total tumor mass glioblastomas. Despite these myeloid populations being ontogenetically distinct, they have been largely conflated. Recent single-cell transcriptomic studies identified genes that distinguish microglia from TAMs. Here we investigated whether translated proteins enriched in microglial or TAM can be used differentiate cells immunohistochemically stained human glioblastoma tissue....
Huntington's disease (HD) is a neurodegenerative disorder that severely affects the basal ganglia and regions of cerebral cortex. While astrocytosis microgliosis both contribute to pathology, contribution gliosis potential factors driving glial activity in human HD cortex less understood. Our study aims identify nuanced indicators which challenging degenerated ganglia, by investigating middle temporal gyrus (MTG), cortical region previously documented demonstrate milder neuronal loss....
The ability to culture neural progenitor cells from the adult human brain has provided an exciting opportunity develop and test potential therapies on cells. To achieve a reliable reproducible cell (AhNPC) system for this purpose, study fully characterized cellular composition of AhNPC cultures, as well possible changes in vitro over prolonged periods. We isolated neurogenic subventricular zone/hippocampus (SVZ/HP) found heterogeneous population comprised several types post-mitotic (neurons,...
Abstract The human brain is a highly vascular organ in which the blood-brain barrier (BBB) tightly regulates molecules entering brain. Pericytes are an integral cell type of BBB, regulating integrity, neuroinflammation, angiogenesis and wound repair. Despite their importance, identifying pericytes amongst other perivascular types deciphering specific role neurovasculature remains challenge. Using primary adult cultures fluorescent-activated sorting, we identified two CD73 + CD45 −...
The present study suggests that when two small populations compete for the same resource and one of them is eliminated after a few generations, natural selection resulting from competition between not likely to have had appreciable effects in determining outcome. This should be interpreted as evidence random genetic changes taking place during this period cannot affect outcome competition, obviously, interspecies may important evolution.