A5103080268- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Metabolism and Genetic Disorders
- Pluripotent Stem Cells Research
- Circadian rhythm and melatonin
- Health, Environment, Cognitive Aging
- Infectious Encephalopathies and Encephalitis
- Fetal and Pediatric Neurological Disorders
- Caveolin-1 and cellular processes
- Ethics in Clinical Research
- History of Medical Practice
- Sexual function and dysfunction studies
- Chronic Myeloid Leukemia Treatments
- Immune Response and Inflammation
- Migraine and Headache Studies
- Hedgehog Signaling Pathway Studies
Auckland City Hospital
2012-2025
University of Auckland
2013-2024
Auckland District Health Board
2018-2024
National Hospital for Neurology and Neurosurgery
1995-2000
University College London
1992-2000
The Royal Free Hospital
1992-1993
Wellington Hospital
1989
Transforming growth factor beta 1 (TGFβ1) is strongly induced following brain injury and polarises microglia to an anti-inflammatory phenotype. Augmentation of TGFβ1 responses may therefore be beneficial in preventing inflammation neurological disorders including stroke neurodegenerative diseases. However, several other cell types display immunogenic potential identifying the effect on these cells required more fully understand its effects inflammation. Pericytes are multifunctional which...
Brain inflammation plays a key role in neurological disease. Although much research has been conducted investigating inflammatory events animal models, potential differences human brain versus rodent models makes it imperative that we also study these phenomena cells and tissue. Primary cell cultures were generated from biopsy tissue of patients undergoing surgery for drug-resistant epilepsy. Cells treated with pro-inflammatory compounds IFNγ, TNFα, IL-1β, LPS, chemokines IP-10 MCP-1...
Body sway and vibration perception in the lower limbs were measured 32 normal subjects 25 patients with peripheral neuropathies; nerve conduction studies also performed neuropathies. was by means of force-plate posturography, three methods used to assess perception: a neurothesiometer, semiquantitative tuning fork, bone vibrator conventional audiometer. increased neuropathies there significant correlation between these measures.d These findings, together lack muscle strength, indicate that...
Abstract Mesial temporal lobe epilepsy (MTLE) is a neurological disorder associated with spontaneous recurrent complex partial seizures and hippocampal sclerosis. Although increased neurogenesis has been reported in animal models of MTLE, not the hippocampus adult human MTLE cases. Here we showed that cells expressing doublecortin (Dcx), microtubule‐associated protein expressed migrating neuroblasts, were present cortex normal brain. In particular, numbers Dcx‐positive observed epileptic...
There is a wealth of biological evidence that supports the concept GABAergic inhibition causal to some genetic generalized epilepsy (GGE) syndromes. Much known about postsynaptic GABAAR channelopathies, however, presynaptic determinants are less well-defined such as role GABA transporters ( SLC6A1 / GAT1; SLC6A11 GAT3), and biosynthesis biology GAD1 GAD67; GAD2 GAD65). In response, our study screened four genes in an international cohort 708 adults children with epilepsy, predominantly GGE...
The impact of long term conditions (LTCs) is an issue for all health care systems in the world today. With aging population and incidence LTCs subsequently increasing, on economics a challenging burden societies. Thus, delivering cost effective high quality major challenge to both payers providers alike. This review discusses various models adopted systems. It then focuses community specialist services respiratory disease context this changing environment concentrates scope evidence support...
The ability to culture neural progenitor cells from the adult human brain has provided an exciting opportunity develop and test potential therapies on cells. To achieve a reliable reproducible cell (AhNPC) system for this purpose, study fully characterized cellular composition of AhNPC cultures, as well possible changes in vitro over prolonged periods. We isolated neurogenic subventricular zone/hippocampus (SVZ/HP) found heterogeneous population comprised several types post-mitotic (neurons,...
Abstract The human brain is a highly vascular organ in which the blood-brain barrier (BBB) tightly regulates molecules entering brain. Pericytes are an integral cell type of BBB, regulating integrity, neuroinflammation, angiogenesis and wound repair. Despite their importance, identifying pericytes amongst other perivascular types deciphering specific role neurovasculature remains challenge. Using primary adult cultures fluorescent-activated sorting, we identified two CD73 + CD45 −...
Abstract Objective To determine the incidence, etiology, and outcome of status epilepticus ( SE ) in Auckland, New Zealand, using latest International League Against Epilepsy ILAE semiological classification. Methods We prospectively identified patients presenting to public or major private hospitals Auckland (population = 1.61 million) between April 6, 2015 5, 2016 with a seizure lasting 10 minutes longer, retrospective review confirm completeness data capture. Information was recorded...
Cannabidiol has shown efficacy in randomized clinical trials for drug-resistant epilepsy specific syndromes that predominantly affect children. However, high-level evidence the and safety of cannabidiol most common form adults, focal epilepsy, is lacking.To investigate efficacy, safety, tolerability transdermally administered adults with epilepsy.A randomized, double-blind, placebo-controlled, multicenter trial at 14 centers Australia New Zealand. Participants were receiving a stable regimen...
Summary: Purpose : There is now a considerable amount of research relating to memory functioning in epilepsy. The majority studies have focused on the retention new information, and few reports measured for past events. This study aims redress this measure efficiency remote Methods A questionnaire was prepared administered three groups patients with epilepsy control group without assessed knowledge public events that occurred between 1980 1991, inclusive. comprised 33 temporal lobe (TLE),...
Neuroinflammation and blood-brain barrier (BBB) disruption are common features of many brain disorders, including Alzheimer's disease, epilepsy, motor neuron disease. Inflammation is thought to be a driver BBB breakdown, but the underlying mechanisms for this unclear. Brain pericytes critical cells maintaining immunologically active. We sought test hypothesis that inflammation regulates by altering pericyte biology.We exposed primary adult human chronic interferon-gamma (IFNγ) 4 days...
Abstract Objective Determination of the real‐world performance a health care system in treatment status epilepticus (SE). Methods Prospective, multicenter population‐based study SE Auckland, New Zealand (NZ) over 1 year, with data recorded EpiNet database. Focus on patterns and determinants duration 30‐day mortality. The incidence, etiology, ethnic discrepancies, seizure characteristics this cohort have been published previously. Results A total 365 patients were included cohort; 326 (89.3%)...
Article abstract—We gave 58 patients with refractory partial seizures who were undergoing video-EEG telemetry a variety of memory tests shortly after the commenced, and we reassessed for this material 48 hours later. Thirty had one or more during period; 22 these complex seizures, secondary generalized both. Eighteen did not have any study period. Patients forgot no than seizures. There was correlation between perfor mance timing number These findings indicate that isolated do gen erally...
The study of microglia isolated from adult human brain tissue provides unique insight into the physiology these immune cells and their role in disorders. Reports post-mortem show regional differences microglial populations, however, have not been fully explored living microglia. In this biopsy was obtained epileptic patients undergoing surgery consisted both cortical areas neurogenic ventricular hippocampal (Hp) areas. Microglia were concurrently regions compared by immunochemistry. Our...
Abstract Aims: To assess the management of epileptic seizures and status epilepticus in adult patients at Auckland City Hospital emergency department. This information will form basis future seizure protocols further research on epilepticus. Methods: The prehospital acute hospital all seen between 1 July 2009 31 December was reviewed with respect to type, presence first seizure, pre‐existing epilepsy diagnosis disposition from Results: Two hundred fifty‐five events were identified 227...