Massive bleeding causes approximately 50% of deaths in patients with major trauma. Most die within 6 h injury, which is preventable at least 10% cases. For these patients, early activation the massive transfusion protocol (MTP) a critical survival factor. With severe trauma, high-mobility group box 1 (HMGB-1, i.e., amphoterin) released into blood, and its levels correlate development systemic inflammatory response, traumatic coagulopathy, fibrinolysis. Previous work has shown that higher...

Abstract Purpose This study aimed to assess the impact of positional changes on upper airway obstruction patterns during drug-induced sleep endoscopy (DISE) in patients with obstructive apnea (OSA) and identify regions most responsive this change. Special focus was placed tongue base, a critical area OSA pathophysiology. Methods prospective conducted from June 2021 2024. DISE performed supine lateral positions simulate effect therapy. Findings were evaluated using VOTE classification....

The present study evaluated whether drug-induced sleep endoscopy (DISE) helps identify the site of obstruction in patients with obstructive apnoea (OSA). A total 51 consecutive polysomnography-confirmed OSA were enrolled this prospective study. presumed was determined according to history, otorhinolaryngologic examination, and polysomnography a therapeutic plan designed before DISE. In 11 severe and/or previously failed continuous positive airway pressure (CPAP) treatment, DISE simultaneous...

Abstract Background Postoperative nausea and vomiting (PONV) is a significant problem following paediatric surgery, volatile anaesthetics are an important cause of this phenomenon. BIS-guided anaesthesia, by reducing the consumption anaesthetics, leads to decrease in PONV adult patients. Study objective Evaluate role anaesthesia incidence PONV. Design Prospective, randomized, double-blind study. Setting A single center study university hospital Czech republic, from June 2021 November 2022....

Emergence delirium (ED) is a postoperative complication in pediatric anesthesia characterized by perception and psychomotor disorder, with negative impact on recovery. As the use of inhalation associated higher incidence ED, we investigated whether titrating depth general BIS monitor can reduce ED. Randomized, prospective, double-blind. Patients undergoing endoscopic adenoidectomy under according to uniform protocol. A total 163 patients both sexes aged 3-8 years were enrolled over 18...

BACKGROUND:Postoperative nausea and vomiting (PONV) is a common complication of pediatric anesthesia, but the overall incidence PONV in patients undergoing adenoidectomy unknown. The aim this controlled study was to compare effect dexamethasone administration with placebo reduce children endoscopic under general anesthesia. MATERIAL AND METHODS:A randomized placebo-controlled included 118 who underwent elective A dexamethasone-treated (0.15 mg/kg) group (Group D) (n=56) C) (n=62) were...

Major abdominal surgery (MAS) is associated with increased morbidity and mortality. The main objective of our study was to evaluate the predictive value heart-rate variability (HRV) concerning development postoperative complications in patients undergoing MAS. secondary objectives were identify relationship HRV use vasoactive drugs during anesthesia, intensive care unit length stay (ICU-LOS), hospital (H-LOS).Sixty-five scheduled for elective MAS enrolled a prospective, single-center,...

Major abdominal surgery (MAS) is high-risk intervention usually accompanied by tissue injury leading to a release of signaling danger molecules called alarmins. This study evaluates the surgical caused two fundamental types gastrointestinal procedures (open and laparoscopy) in relation inflammation elicited alarmins.Patients undergoing MAS were divided into mixed laparoscopy group (LPS) an open (LPT). Serum levels alarmins (S100A8, S100A12, HMGB1, HSP70) biomarkers (leukocytes, C-reactive...

Aim: To determine the inter-observer reproducibility of 15 tests used for predicting difficult tracheal intubation (DI). Material and methods: Following local ethics committee approval informed consent, 101 volunteers were examined by two assessors using DI. The who blinded to results other, each volunteer independently. Cohen's kappa (κ) or first-order agreement coefficient (AC1) measure between assessor ratings on a qualitative scale. Agreement quantitative outcomes was described...

Abstract Background Anticoagulation during extracorporeal membrane oxygenation (ECMO) might still lead to severe bleeding complications. Heparin is the most frequently used anticoagulant, but novel drugs could be promising. Argatroban a new alternative heparin. To date, no robust studies have confirmed clear superiority of argatroban (AG) over heparin, although it has some advantages and may safer. Study Design Methods An observational study was conducted in all adult veno‐venous ECMO...

Introduction and Importance: Some experimental studies on brain injury associated with traumatic (TBI) hypoxic-ischaemic encephalopathy (HIE) reveal a positive effect of hyperbaric oxygen therapy (HBOT).However, in clinical medicine, most the scientific evidence available current literature relates only to TBI.Methods: The primary objective is empirically assess efficacy HBOT mitigating symptoms disability children, view elucidating its therapeutic potential benefits.Outcomes: A total 21...

Background:Acute kidney injury (AKI) is a common cause of organ failure in patients after major trauma and associated with increased morbidity mortality.Early identification at risk enables the implementation bundle supportive care, which reduces incidence AKI.The primary objective our study was to investigate whether levels biomarkers on admission predicted onset early AKI serious injuries. Material/Methods:This prospective observational included 98 adult both sexes (injury severity score...

Drug-induced sleep endoscopy (DISE) reveals epiglottic collapse to be a frequent cause of obstructive apnea (OSA) and intolerance positive airway pressure (PAP). These patients require different management. This prospective study aimed compare transoral laser epiglottopexy outcomes in with OSA caused by the patients’ previous PAP outcomes. Fifteen consecutive adult during DISE were included; ten analyzed. Before inclusion, was indicated ineffective six patients, one whom underwent...

Summary For microcirculation research there is a need for baseline data and feasibility protocols describing of various organs. The aim our study was to examine the reliability reproducibility sidestream dark‐field (SDF) imaging within renal cortical in rats. Renal observed using SDF probe placed on exposed surface via upper midline laparotomy. Video sequences recorded intermittently short apneic pauses were analyzed off‐line by AVA 3.0 software (MicroVision Medical, Amsterdam, Netherlands)....

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<title>Abstract</title> Background Massive bleeding causes approximately 50% of deaths in patients with major trauma. Most die within 6 hours injury, which is preventable at least 10% cases. For these patients, early activation the massive transfusion protocol (MTP) a critical survival factor. With severe trauma, high-mobility group box 1 (HMGB-1, i.e., amphoterin) released into blood, and its levels correlate development systemic inflammatory response, traumatic coagulopathy, fibrinolysis....

<title>Abstract</title> Background Massive bleeding causes approximately 50% of deaths in patients with major trauma. Most die within 6 hours injury, which is preventable at least 10% cases. For these patients, early activation the massive transfusion protocol (MTP) a critical survival factor. With severe trauma, high-mobility group box 1 (HMGB-1, i.e., amphoterin) released into blood, and its levels correlate development systemic inflammatory response, traumatic coagulopathy, fibrinolysis....

Spinální (intratékální) aplikace opioidů se stala během posledních desetiletí ověřenou metodou analgezie pro perioperační období. V praxi však stále naráží na obavy z možných komplikací, nutnost zvýšené pooperační monitorace a nedostupnost vhodného komerčního preparátu tuzemském trhu. S pokračujícím výzkumem v této oblasti vyvíjí patofyziologický výklad nežádoucích účinků jejich možná prevence. Stejně tak i uplatnění spinálních klinické praxi. Při vhodném použití jedná o bezpečnou metodu,...