A5063487238- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Extracellular vesicles in disease
- Ion Channels and Receptors
- Peptidase Inhibition and Analysis
- Bladder and Urothelial Cancer Treatments
- FOXO transcription factor regulation
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Kruppel-like factors research
- Microtubule and mitosis dynamics
- interferon and immune responses
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
Sun Yat-sen University
2017-2025
Sun Yat-sen University Cancer Center
2017-2025
Southern Medical University
2017-2020
Abstract Bladder cancer (BC) is one of the most common tumors characterized by a high rate relapse and lack targeted therapy. Here, YEATS domain‐containing protein 4 (YEATS4) an essential gene for BC cell viability using CRISPR‐Cas9 library screening reported, that HUWE1 E3 ligase responsible YEATS4 ubiquitination proteasomal degradation Protein Stability Regulators Screening Assay. KAT8‐mediated acetylation impaired its interaction with consequently prevented degradation. The levels KAT8...
Abstract Aberrant transcriptional and epigenetic landscape plays crucial roles in the progression of bladder cancer (BC). However, effective therapeutic targets derived from these processes remain undeveloped. This study pinpoints SET‐domain‐containing protein 8 (SETD8) as a pivotal gene that promotes tumor growth through screening with CRISPR‐Cas9 library targeting factors. BC patient samples display elevated SETD8 expression, higher expression correlates poorer prognosis. Further, MYC is...
Abstract Immune checkpoint inhibitors (ICIs) show promise as second‐line treatment for advanced bladder cancer (BLCA); however, their responsiveness is limited by the immune evasion mechanisms in tumor cells. This study conduct a Cox regression analysis to screen mRNA‐binding proteins and reveals an association between Ras GTPase‐activating protein‐binding protein 1 (G3BP1) diminished effectiveness of ICI therapy patients with BLCA. Subsequent investigation demonstrates that G3BP1 enhances...
RNA-binding proteins (RBPs) are key regulators of gene expression. RBP dysregulation is reported to play essential roles in tumorigenesis. However, the role RBPs urothelial carcinoma bladder (UCB) only starting be unveiled. Here, we comprehensively assessed mRNA expression landscape 104 from two independent UCB cohorts, Sun Yat-sen University Cancer Center (SYSUCC) and The Genome Atlas (TCGA). Fragile X-related 1 (FXR1) was identified as a novel cancer driver UCB. FXR1 overexpression found...
Stromal interaction molecule (STIM) 2 is a key calcium-sensing that regulates the stabilization of calcium ions (Ca2+) and therefore downstream Ca2+-associated signaling cellular events. We hypothesized STIM2 epithelial-mesenchymal transition (EMT) to promote breast cancer metastasis. determined effects gain, loss, rescue on motility, levels EMT-related proteins, secretion transforming growth factor-β (TGF-β). also conducted bioinformatics analyses in vivo assessments metastasis using...
Dysregulation of transcription is a hallmark cancer, including bladder cancer (BLCA). CRISPR-Cas9 screening using lentivirus library with single guide RNAs (sgRNAs) targeting human factors and chromatin modifiers used to reveal genes critical for the proliferation survival BLCA cells. As result, nuclear factor Y subunit gamma (NFYC)-37, but not NFYC-50, observed promote cell tumor growth in BLCA. Mechanistically, NFYC-37 interacts CBP SREBP2 activate mevalonate pathway transcription,...
Bladder cancer (BC) is one of the most common malignant cancers, with poor prognosis and high incidence. Cisplatin standard chemotherapy for muscle invasive bladder cancer; however, resistance remains a major challenge. Moreover, oncogenic signalling specific mechanisms underlying cisplatin in BC remain largely unclear METHODS: In this study, RT-PCR, Western blot, immunofluorescence, immunohistochemistry were used to measure gene protein expression. Colony formation assay flow cytometry...
Chemoresistance poses a critical obstacle in bladder cancer (BCa) treatment, and effective interventions are currently limited. Elevated oxidative phosphorylation (OXPHOS) has been linked to stemness, determinant of chemoresistance. However, the mechanisms underlying increased OXPHOS during cell chemoresistance remain unclear. This study revealed that mitochondrial translational activator cytochrome oxidase subunit 1 (TACO1) is stemness cisplatin resistance BCa cells. Mechanistically, TACO1...
Abstract Background Bladder cancer (BLCA) is a common malignancy characterized by dysregulated transcription and lack of effective therapeutic targets. In this study, we aimed to identify evaluate novel targets with clinical potential essential for tumor growth in BLCA. Methods CRISPR-Cas9 screening was used factors bladder cell viability. The biological functions KLF16 were investigated both vitro vivo. regulatory mechanism between MYC elucidated through series analyses, including RNA...
Bladder cancer (BC) is one of the most prevalent malignancies worldwide, but it lacks effective targeted therapy due to its elusive molecular mechanism. Therefore, important further investigate mechanisms that mediate BC progression. By performing a tumor tissue-based gene microarray and shRNA library screening, we found recombination signal binding protein for immunoglobulin kappa J region (RBPJ) interacting tubulin associated 1 (RITA1) crucial growth cells. Moreover, RITA1 aberrantly...
<p>Table S2</p>
<p>PDF file, 40K.</p>
<p>PDF file, 118K, The relationship between 20-miRNA signature risk score and survival status of HCC patients.</p>
<p>PDF file, 220K, Classification and Prediction of HCC NC samples by 30-miRNA signature.</p>
<div>Abstract<p><b>Purpose:</b> MicroRNAs (miRNAs) play important roles in the development and progression of cancer. The aim this study is to identify miRNA expression signatures hepatocellular carcinoma delineate their clinical significance for carcinoma.</p><p><b>Experimental Design:</b> Patients with carcinoma, undergoing hepatectomy were randomly divided into training set (60 patients) test (50 patients). Other 56 patients used as an...
<div>Abstract<p><b>Purpose:</b> MicroRNAs (miRNAs) play important roles in the development and progression of cancer. The aim this study is to identify miRNA expression signatures hepatocellular carcinoma delineate their clinical significance for carcinoma.</p><p><b>Experimental Design:</b> Patients with carcinoma, undergoing hepatectomy were randomly divided into training set (60 patients) test (50 patients). Other 56 patients used as an...