A5016911517- Cardiac, Anesthesia and Surgical Outcomes
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Frailty in Older Adults
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
- Trauma and Emergency Care Studies
- Colorectal Cancer Surgical Treatments
- PARP inhibition in cancer therapy
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- Multiple and Secondary Primary Cancers
- Cervical Cancer and HPV Research
- Health Systems, Economic Evaluations, Quality of Life
- Breast Cancer Treatment Studies
- Ultrasound in Clinical Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Economic and Financial Impacts of Cancer
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Lymphoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Intestinal and Peritoneal Adhesions
- Ectopic Pregnancy Diagnosis and Management
Johannes Gutenberg University Mainz
2020-2025
University Medical Center of the Johannes Gutenberg University Mainz
2020-2024
Klinik für Frauenheilkunde
2020-2024
University of Birmingham
2020
Stryker (United Kingdom)
2020
AstraZeneca (Brazil)
2020
Pfizer (United Kingdom)
2020
Merck (Germany)
2020
Heidelberg University
2019
Gastrointestinal dysfunctions in individuals with autism spectrum disorder are poorly understood, although they common among this group of patients. FOXP1 haploinsufficiency is characterized by autistic behavior, language impairment, and intellectual disability, but feeding difficulties gastrointestinal problems have also been reported. Whether these primary impairments, the result altered eating or side effects psychotropic medication remains unclear. To address question, we investigated...
Introduction: Epidural anesthesia is a standard procedure to mitigate pain during surgery for endometrial cancer (EC). Little data exist about the influence of epidural on oncological outcome in elderly patients with EC. This retrospective study aims investigate potential correlations between and recurrence Methods: We screened medical records ≥ 60 years treated surgically EC at University Medical Center Mainz January 2008 December 2019. All women underwent general (GA) alone or combined...
Abstract Introduction Surgery for endometriosis is usually performed through minimally invasive surgery, either by experienced surgeons or supervised gynecology residents during their surgical training. This trial aimed to assess the influence of experience on efficiency and safety surgery treatment early-stage endometriosis. Material Methods Post- introperative complications rates length stay patients with stage I II (revised American Society Reproductive Medicine (rASRM)) undergoing...
Background: Immune checkpoint inhibitors (ICIs) have emerged as an essential therapeutic approach in treating many solid tumors. ICIs enhance the body’s anti-tumor T-cell activity, resulting a novel spectrum of immunotherapy-related side effects. This adverse events differs significantly from effects conventional chemotherapy. It, therefore, requires special attention diagnosis and management (irAEs). The present study aimed to retrospectively analyze incidence, diagnosis, irAEs patients...
Despite the growing understanding of carcinogenesis pelvic high-grade serous carcinoma (HGSC) ovary and peritoneum its precursor lesion tubal intraepithelial (STIC), evidence-based proven recommendations on clinical management patients with STIC are lacking so far.A questionnaire containing 21 questions was developed to explore experience diagnosis STICs diagnostic, surgical histopathological approaches in Germany. Overall, 540 heads department all German gynaecological centres were asked...
We evaluated the prognostic impact of various global health assessment tools in patients older than 60 years with ovarian cancer (OC).G-8 geriatric screening tool (G-8 score), Lee Schonberg index, Eastern Cooperative Oncology Group (ECOG) performance status, and Charlson Comorbidity Index (CCI) were determined retrospectively a consecutive cohort elderly OC. Univariate multivariate Cox regression analyses Kaplan-Meier method performed to analyze preoperative status on survival.116 entered...
Perioperative red blood cell (RBC) transfusions have been associated with increased morbidity and worse oncological outcome in some solid neoplasms. In order to elucidate whether RBC themselves, the preoperative anemia of cancer (AOC), or impaired global health status might explain this impact on patients endometrial (EC) ovarian (OC), we performed a retrospective, single-institution cohort study. Women older than 60 years EC OC were included. The influence transfusions, AOC, frailty...
Abstract Purpose The aim of this retrospective study was to evaluate the prognostic impact global health status assessment tools in elderly patients with endometrial cancer (EC) on survival. Methods Preoperative frailty assessed by G8 geriatric screening tool (G8 Score), Lee Schonberg index, Charlson Comorbidity index and American Society Anesthesiologists Physical Status System women older than 60 years EC. Univariable multivariable Cox-regression analyses, as well Kaplan–Meier survival...
Breast cancer (BC) poses a challenge in establishing new treatment strategies and identifying prognostic predictive markers due to the extensive genetic heterogeneity of BC. Very few studies have investigated impact mRNA expression these genes on survival BC patients. Methods: We examined breast gene type 1 (BRCA1), 2 (BRCA2), partner localizer BRCA2 (PALB2) metastasis-free (MFS) patients with early using microarray analysis. Results: The study was performed cohort 461 median age 62 years at...
Abstract Purpose Frailty is a frequent and underdiagnosed multidimensional age-related syndrome, involving decreased physiological performance reserves marked vulnerability against major stressors. To standardize the preoperative frailty assessment identify patients at risk of adverse surgical outcomes, commonly used global health tools were evaluated. We aimed to assess three interdisciplinary screening assessments investigate influence status with in-hospital complications irrespective...
Introduction: Metronomic chemotherapy (MCT) is increasingly used in oncology due to its favorable therapeutic index. There still a lack of evidence for MCT metastatic breast cancer (MBC). In this retrospective unicenter study, we demonstrated real-word data on MBC. Methods: MBC patients who received metronomic oral cyclophosphamide (CTX) (50 mg daily) and methotrexate (MTX) (2.5 every other day), CTX capecitabine (CAPE) (500 thrice daily), CTX, or vinorelbine (VRL) (30 alone at least 4 weeks...
Zielsetzung: Seröse tubare intraepitheliale Karzinome (STIC) gelten als Vorläuferläsionen von pelvinen high-grade serösen Karzinomen. Die Inzidenz, Prognose und Therapie den seltenen STICs sind noch unklar. Seit 2021 isolierte meldepflichtig, sodass wir alle registrierten in Rheinland-Pfalz ausgewertet haben.
<h3>Introduction/Background</h3> Frailty is an underdiagnosed multidimensional age-related syndrome. Preoperative frailty assessment recommended in the guidelines for cancer patients. This study aims to investigate impact of a standardized, two-step, multidisciplinary evaluation on complications and prognosis women with gynecological malignancies, surgically treated. <h3>Methodology</h3> In this prospective clinical trial, all malignancies regardless previous treatments or histological type...
We retrospectively investigated the widely used radiosensitisers cisplatin and mitomycin C/5-fluorouracil (5-FU) in patients with locally advanced vulvar cancer for outcome toxicity.We screened archive treated chemoradiation diagnosed between 01/2010 08/2021 at our institution. The impact of both on prognosis was compared using Kaplan-Meier method Cox-regression analysis.One hundred forty-three were screened. Twenty-nine received (mitomycin C/5-FU n = 14; 12; others 3) as a primary,...
<h3>Introduction/Background*</h3> Treatment of vulvar cancer contains surgery if applicable and often primary or neo-/adjuvant chemoradiation. Cisplatin Mitomycin/5-FU are widely used radiosensitizers in cancer, although evidence is limited. We retrospectively investigated both for outcome toxicity. <h3>Methodology</h3> screened the archive patients treated with chemoradiation pathologically-confirmed squamous cell vulva between 01/2010 – 02/2021 at our institution. The impact on prognosis...
Background: Lymph node involvement is the most important prognostic factor for recurrence and survival in vulvar cancer. Sentinel (SN) procedure can be offered well-selected patients with early This study aimed to assess current management practices respect sentinel women cancer Germany. Methods: A Web-based survey was conducted. Questionnaires were e-mailed 612 gynecology departments. Data summarized as frequencies analyzed using chi-square test. Results: total of 222 hospitals (36.27%)...
<h3>Introduction/Background</h3> Epidural anaesthesia is a standard procedure to mitigate pain during endometrial cancer (EC) surgery. Little data exist about the influence of epidural on oncological outcome in elderly patients with EC. This retrospective study aims investigate potential correlations between and recurrence <h3>Methodology</h3> We screened archives treated surgically for EC at University Medical Centre Mainz January 2008 December 2019. All women underwent general (GA) alone...
<h3>Introduction/Background</h3> The omission of state the art (SOTA) surgery results in lower survival rates elderly. Here, we report an interim-analysis a prospective observational cohort study on impact praeoperative, multidisciplinary, two-step frailty assessment gynecological malignancies. <h3>Methodology</h3> Women were included meeting one following criteria 1) age 60 years and older, 2) BMI>30kg/m<sup>2</sup> or 3) subjective frail impression. screening step uses G8-Score...
<h3>Introduction/Background</h3> Endometrial cancer (EC) is the most common malignancy of female genital tract in developed countries and normally treated by surgery. Frail EC patients should be identified preoperatively to reduce their risk adverse surgical outcomes. These are first results a systematic, preoperative frailty screening regarding perioperative complication rates. <h3>Methodology</h3> All with standardized treatment, regardless actual stage previous treatments, were screened...
Objective Despite the growing understanding of carcinogenesis high-grade serous ovarian cancer and its precursor lesion tubal intraepithelial carcinoma (STIC), evidence based proven recommendations on clinical management patients with STIC are lacking.
Zielsetzung Die metronomische Chemotherapie (MCT) wird in der Onkologie aufgrund des günstigen therapeutischen Index zunehmend verwendet. Beim metastasierten Mammakarzinom (MBC) ist die MCT noch nicht ausreichend erprobt. Diese unizentrische, retrospektive Kohortenstudie sollte Effektivität und Toxizität bei MBC untersuchen.