A5018109734- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Zoonotic diseases and public health
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Poxvirus research and outbreaks
- Animal Disease Management and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Viral Infections and Outbreaks Research
- Virus-based gene therapy research
- Streptococcal Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Bacillus and Francisella bacterial research
- Drug Transport and Resistance Mechanisms
Catholic University of Central Africa
2017-2023
Ministry of Public Health
2021-2023
Ministry of Defence
2018
University of Ngaoundéré
2018
Johns Hopkins Berman Institute of Bioethics
2015
University of Venda
2008-2013
The death toll and economic loss resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are stark reminders that we vulnerable to zoonotic viral threats. Strategies needed identify characterize animal viruses pose greatest risk of spillover spread in humans inform public health interventions. Using expert opinion scientific evidence, identified host, viral, environmental factors contributing virus humans. We then developed a ranking framework interactive web...
Abstract Monkeypox virus (MPXV) is a reemerging of global concern. An outbreak clade I MPXV affected 20 captive chimpanzees in Cameroon 2016. We describe the epidemiology, virology, phylogenetics, and clinical progression this outbreak. Clinical signs included exanthema, facial swelling, perilaryngeal eschar. Mpox can be lethal chimpanzees, with death likely resulting from respiratory complications. advise avoiding anesthesia animals to reduce likelihood death. This presented risk animal...
Abstract While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report dynamics lineages March 2020 to 2022 in Cameroon. Of 760 whole-genome sequences successfully generated by national genomic surveillance network, 74% were viral sub-lineages origin and non-variants concern, 15% Delta, 6% Omicron, 3% Alpha 2% Beta variants. The pandemic was driven wave 1 (16 weeks, 2.3% CFR), variants 2 (21 1.6% Delta 3 (11 2.0% omicron 4 (8...
The viral load (VL) in patients receiving antiretroviral therapy (ART) is the best predictor of treatment outcome. anticipated benefits VL monitoring depend on actual uptake test results for clinical decisions. objective this study was to assess and utilization decisions HIV Cameroon, from 2013 2017.This a retrospective cohort analysis data files ART at Buea, Limbe, Bamenda Bafoussam regional hospital centers. A simple random pick six file blocks performed each shelf that corresponded year...
Zoonotic spillover of animal viruses into human populations is a continuous and increasing public health risk. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the global impact emergence. Considering history diversity coronaviruses (CoVs), especially in bats, SARS-CoV-2 will likely not be last to from animals populations. We sampled tested wildlife Central African country Cameroon determine which CoVs are circulating how they relate previously detected CoVs. collected...
The recent Ebola and Zika virus epidemics in some parts of Africa Asia have showcased the porosity disaster preparedness response, not only affected countries, but on a global scale. For epidemic, scientifically robust research was started late during course with waste resources lost opportunities. Research Ethics Committees significant role to play regards epidemic response for future. This paper presents key challenges opportunities ethics review emergencies, specifically low middle income...
Bacteriological profile and antimicrobial susceptibility patterns of urine culture isolates were determined among patients in the Ndjamena General Hospital, a National Reference centre.A cross-sectional study was carried out from July to November 2014. Six hundred sixty enrolled, whom cytobacteriological examination prescribed. Urine collected cultured. Bacterial identification performed using Vitek 2 compact automated system.216 recovered (age range: 10-90 years). E. coli pathogen...
Introduction: Staphylococcus aureus is an important pathogen responsible for hospital and community acquired infection(s). Emerging resistance to methicillin in this organism has left physicians with few therapeutic alternatives treat infections caused by it. This study was aimed at determining the antibiotic susceptibility patterns of strains isolated Yaounde Central Hospital, Cameroon.
Raltegravir, an integrase inhibitor, is not a component of the current South African antiretroviral treatment guidelines, but it could be introduced in near future as cases virological failures from regimens begin to occur. The aim this study was analyze complete HIV gene obtained individuals at two sites northeastern Africa for presence Raltegravir associated drug resistant mutations and viral subtypes based on gene. Examination against other inhibitors, such Elvitegravir Dolutegravir, also...
Abstract Infection with drug resistant viruses influences the outcome of antiretroviral therapy (ART). This study was carried out to determine transmitted genetic resistance profile in a cohort patients prior initiation treatment at two sites northern South Africa. These were among first benefit from drugs this region. Data on HIV are also limited Africa; and testing is not undertaken. In 2008, 80 protease reverse transcriptase nucleotide sequences obtained analyzed for using calibrated...
Adenoviruses (AdVs) are diverse pathogens of humans and animals, with several dozen bat AdVs already identified. Considering that over 100 human known, the huge diversity species, many likely remain undiscovered. To learn more about AdV prevalence, evolution, we sampled tested bats in Cameroon using PCR assays for viral host DNA. DNA was detected 14 % 671 animals belonging to 37 different species. There a correlation between species roosting larger groups detection. The belonged 28 44...
Mortality in children accounts for 15% of all AIDS-related deaths globally, with a higher burden among Cameroonian (25%), likely due to poor virological response. We sought evaluate viral suppression (VS) and its determinants nationally representative paediatric young adult population receiving antiretroviral therapy (ART). A cross-sectional multicentric study was conducted (
Data on genetic polymorphisms associated with response to anti-HIV drugs has accumulated over the years. Information how influence drug metabolism and transport target sites is important in guiding dosage or selection of appropriate alternative therapies. This study determined frequency MDR1 C3435T CYP2B6 G516T efavirenz nevirapine, a population South African HIV infected patients. In addition, association immunologic virologic factors was investigated. A 207bp exon 26 161bp 4 were obtained...
Data on genetic polymorphisms associated with response to anti-HIV drugs has accumulated over the years. Information how influence drug metabolism and transport target sites is important in guiding dosage or selection of appropriate alternative therapies. This study determined frequency MDR1 C3435T CYP2B6 G516T efavirenz nevirapine, a population South African HIV infected patients. In addition, association immunologic virologic factors was investigated. A 207bp exon 26 161bp 4 were obtained...
Vaginal candidiasis is considered as an important public health problem worldwide and its incidence has increased nowadays. In recent years, inappropriate disproportionate use of antifungal drugs, automedication well non compliance have caused drug resistance.This study aimed at determining the in vitro susceptibility patterns Candida speciesisolated from female genital tract Yaoundé Bethesda Hospital Cameroon. Two hundred fourthy five women (age range: 15 years to 49 years) attending...
Human immunodeficiency virus type 1 (HIV-1) has a high propensity for recombination. The epidemic in South Africa is predominantly driven by HIV-1 subtype C with occasional description of non-subtype and intersubtype recombinant viruses. This report presents the genetic analysis unique variant from northern comprised exclusively subsubtype A1 parental Boot scanning near full-length genome jumping profile Hidden Markov Model revealed genomic arrangement seven breakpoints recombination...
Aim. We studied the prevalence of resistance mutations in drug-naïve HIV-infected individuals at Bela-Bela treatment site to gather information on presence antiretroviral (ARV) drug-resistant viruses populations, so as improve guidance. Subjects and methods. Drug-naive HIV-1-infected were sequentially recruited between February 2008 December from visiting voluntary counseling testing (VCT) services HIV/AIDS Wellness Clinic. Viral subtyping was done by phylogenetic analysis; determined...
Transfusion-transmissible infectious microorganisms including bacteria and viruses are among the greatest threats to blood safety for recipient. The prevalence risk factors of HTLV-1/2 other borne diseases were determined donors in Yaounde Central Hospital, Cameroon.Design: cross sectional study. Setting: bank unit Cameroon. Subjects: a consecutive sample 265 apparently healthy adult donors. Investigations: Search presence hepatitis B surface antigen (AgHBs) antibodies human T-lymphotropic...
In May 2016, highly pathogenic avian influenza virus of the subtype A/H5N1 was detected in Cameroon an industrial poultry farm at Mvog-Betsi, Yaoundé (Centre region), with a recorded sudden increase deaths among chickens, and overall mortality rate 75%. The spread further caused new outbreaks some parts country. total, 21 were confirmed from 2016 to March 2017 (six Centre, six West, eight South one Adamaoua regions). This resulted estimated total loss 138,252 birds (44,451 due infection...