A5007677433- Photoacoustic and Ultrasonic Imaging
- Medical Imaging and Pathology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Ultrasound Imaging and Elastography
- Advanced Fluorescence Microscopy Techniques
- Traffic and Road Safety
- Neurogenesis and neuroplasticity mechanisms
- Optical Imaging and Spectroscopy Techniques
- Traffic Prediction and Management Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Pediatric Urology and Nephrology Studies
- Neuroscience and Neuropharmacology Research
- Optical Coherence Tomography Applications
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Anomalies
- Safety Warnings and Signage
- Neurosurgical Procedures and Complications
- Renal cell carcinoma treatment
- Cerebrospinal fluid and hydrocephalus
- Ultrasonics and Acoustic Wave Propagation
- Renal and related cancers
Baylor College of Medicine
2023-2025
The University of Texas at Austin
2019-2024
Indianapolis Zoo
2024
University of the West of Scotland
2020
Novo Nordisk Foundation
2019
University of Copenhagen
1992-2019
Indiana State University
2016-2019
Women and Children’s Health Research Institute
2014-2018
University of Alberta
2014-2018
Southern Illinois University Edwardsville
2012-2016
Brain injury causes astrocytes to assume a reactive state that is essential for early tissue protection, but how affect later reparative processes incompletely understood. In this study, we show are crucial vascular repair and remodeling after ischemic stroke in mice. Analysis of astrocytic gene expression data reveals substantial activation transcriptional programs related stroke. vivo two-photon imaging provides evidence contacting newly formed vessels cortex surrounding photothrombotic...
To examine how common patient factors affect screening mammographic sensitivity and cancer stage at diagnosis.The authors used a population-based database of 183,134 mammograms statewide tumor registry to identify 807 breast cancers detected mammography.Sensitivity varied significantly with ethnicity, use estrogen replacement therapy, density, age. Sensitivity was 54% (13 24) in women younger than 40 years, 77% (121 157) aged 40-49 78% (224 286) 50-64 81% (277 340) older 64 years. 68% (162...
PURPOSE: To determine the sensitivity and specificity of ultrasonography (US) for detecting parenchymal renal pelvis calculi to establish accuracy US determining size number calculi. MATERIALS AND METHODS: A total 123 computed tomographic (CT) examinations were compared retrospectively presence The was determined individual at least one calculus per examination. Retrospective findings with original interpretation. sizes in longest axis on CT images, detection left right kidneys compared. use...
Neurovascular coupling, the close spatial and temporal relationship between neural activity hemodynamics, is disrupted in pathological brain states. To understand altered neurovascular disorders, longitudinal, simultaneous mapping of hemodynamics critical yet challenging to achieve. Here, we use a multimodal platform mouse model stroke realize long-term, spatially resolved tracking intracortical cerebral blood flow same regions. We observe pronounced dissociation that occurs immediately...
Stroke causes remodeling of vasculature surrounding the infarct, but whether and how vascular contributes to recovery are unclear. We established an approach monitor compare changes in structure blood flow with high spatiotemporal precision after photothrombotic infarcts motor cortex using longitudinal 2-photon multiexposure speckle imaging mice both sexes. A spatially graded pattern structural peri-infarct unfolded over first 2 weeks stroke, characterized by vessel loss formation, selective...
Abstract Stroke enhances proliferation of neural precursor cells within the subventricular zone (SVZ) and induces ectopic migration newborn towards site injury. Here, we characterize identity arising from SVZ after stroke uncover a mechanism through which they facilitate repair functional recovery. With genetic lineage tracing, show that SVZ-derived migrate cortical photothrombotic in mice are predominantly undifferentiated precursors. We find ablation or conditional knockout VEGF impairs...
To characterize chest radiographic features of Hantavirus pulmonary syndrome.Initial and follow-up radiographs from 16 patients with confirmed syndrome were reviewed for findings either cardiogenic edema or due to increased permeability the alveolar capillary membranes.Findings indicative interstitial present more frequently (14 [88%] patients) than is typically seen in adult respiratory distress (5%). Alveolar flooding subsequently developed 11 (69%) was not peripheral pattern usually acute...
Abstract The photothrombotic stroke model generates localized and reproducible ischemic infarcts that are useful for studying recovery mechanisms, but its failure to produce a substantial penumbra weakens resemblance human stroke. We examined whether modification of this approach, confining photodamage arteries on the cortical surface (artery-targeted photothrombosis), could better reproduce aspects penumbra. Following artery-targeted or traditional photothrombosis motor cortex mice,...
The endocrine cells of the pancreas develop from endoderm and yet display several characteristics a neuronal phenotype. During embryonic life, ductal epithelial give rise to first glugagon-producing (alpha-cells) then that express insulin (beta-cells), somatostatin (delta-cells), pancreatic polypeptide (PP-cells) in sequential order. are believed arise stem cell with traits. developmental lineage common neuron-like progenitor is evidenced by: transient coexpression more than one...
We assessed the elemental and biochemical effects of rehabilitation after intracerebral hemorrhage, with emphasis on iron-mediated oxidative stress, using a novel multimodal biospectroscopic imaging approach.Collagenase-induced striatal hemorrhage was produced in rats that were randomized to enriched or control intervention starting day 7. Animals euthanized 14 21, period ongoing cell death. used techniques precisely determine molecular changes 14. Hemoglobin content resonance Raman...
BACKGROUND This project was designed to collect and link population-based mammography breast carcinoma data assess the performance of community screening. METHODS Computerized were collected from all radiology practices in Albuquerque, New Mexico. The linked by computer match carcinomas a statewide cancer registry. Analysis is based on 126,466 screening mammogram studies performed 87,443 female residents Mexico between ages 35 84 5 groups. Sensitivity, specificity, positive predictive value,...
Recent advances in two-photon fluorescence microscopy (2PM) have allowed large scale imaging and analysis of blood vessel networks living mice. However, extracting network graphs vector representations for the dense capillary bed remains a bottleneck many applications. Vascular vectorization is algorithmically difficult because vessels shapes sizes, samples are often unevenly illuminated, image volumes required to achieve good statistical power. State-of-the-art, three-dimensional, vascular...
Here we introduce a fiber amplifier and diamond Raman laser that output high powers (6.5 W, 1.3 W) at valuable wavelengths (1060 nm, 1250 nm) for two-photon excitation of red-shifted fluorophores. These custom sources are both simple to construct cost-efficient in comparison similar commercial alternatives. Furthermore, they operate repetition rate (80 MHz) allows fast image acquisition using resonant scanners. With our system demonstrate compatibility with scanning, the ability acquire...
Potentially fatal intracranial pressure (ICP) rises commonly occur after large intracerebral hemorrhages (ICH). We monitored ICP infusing 100–160 μL of autologous blood (vs. 0 control) into the striatum rats in order to test validity this common model with regard elevations. Other endpoints included body temperature, behavioral impairment, lesion volume, and edema. Also, we evaluated hippocampal CA1 sector somatosensory cortical neuron morphology assess whether global ischemic injury...
Increased intracranial pressure (ICP) after stroke can lead to poor outcome and death. Novel treatments combat ICP rises are needed. The carbonic anhydrase inhibitor acetazolamide diminishes cerebrospinal fluid (CSF) production, reduces in healthy animals, is beneficial for idiopathic hypertension patients. We tested whether mitigates elevations by presumably decreasing CSF volume collagenase-induced striatal hemorrhage rats. confirmed that did not adversely affect hematoma formation this...
The diagnosis of abdominal actinomycosis is difficult because its relative infrequency and imitation other diseases. We present four cases in which these difficulties were experienced show the utility CT suggesting this disease. Aspiration, biopsy, proper culture technique, conjunction with typical findings transfascial multiple organ involvement, led to all cases.