Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific clinical applications. We showed that nanoelectronic thread (NET) subcellular dimensions, ultraflexibility, cellular surgical footprints form reliable, glial scar-free neural integration. demonstrated NET reliably detected tracked units for months; impedance, noise level, single-unit yield, signal...

Understanding brain functions at the circuit level requires time-resolved simultaneous measurement of a large number densely distributed neurons, which remains great challenge for current neural technologies. In particular, penetrating electrodes allow recording from individual neurons high temporal resolution, but often have larger dimensions than biological matrix, induces significant damage to tissues and therefore precludes implant density that is necessary mapping neuronal populations...

Objective. Implanted microelectrodes provide a unique means to directly interface with the nervous system but have been limited by lack of stable functionality. There is growing evidence suggesting that substantially reducing mechanical rigidity neural electrodes promotes tissue compatibility and improves their recording stability in both short- long-term. However, miniaturized dimensions ultraflexibility desired for mitigating responses preclude probe's self-supported penetration into brain...

Brain function can be best studied by simultaneous measurements and modulation of the multifaceted signaling at cellular scale. Extensive efforts have been made to develop multifunctional neural probes, typically involving highly specialized fabrication processes. Here, we report a novel probe platform realized applying ultrathin nanoelectronic coating (NEC) on surfaces conventional microscale devices such as optical fibers micropipettes. We fabricated NECs planar photolithography techniques...

Neurovascular coupling, the close spatial and temporal relationship between neural activity hemodynamics, is disrupted in pathological brain states. To understand altered neurovascular disorders, longitudinal, simultaneous mapping of hemodynamics critical yet challenging to achieve. Here, we use a multimodal platform mouse model stroke realize long-term, spatially resolved tracking intracortical cerebral blood flow same regions. We observe pronounced dissociation that occurs immediately...

SUMMARY Monitoring neural population activity at single-cell resolution is essential for driving fundamental research and clinical innovations. However, translating advanced recording techniques from animal models to humans remains a significant challenge. Flexible electrodes have recently emerged as powerful tools large-scale single-unit recordings due their superior biocompatibility high density. Here, we demonstrate reliable, high-density during intraoperative procedures in human patients...

Single-unit (SU) recording in nonhuman primates (NHPs) is indispensible the quest of how brain works, yet electrodes currently used for NHP are limited signal longevity, stability, and spatial coverage. Using new structural materials, microfabrication, penetration techniques, we develop a mechanically robust ultraflexible, 1 µm thin electrode array (MERF) that enables pial high-density, large-scale, chronic neurons along both vertical horizontal cortical axes primate brain. Recording from...

A numerical analysis is presented of the Rayleigh–Taylor instability (RTI) in presence an external electric field, with emphasis on nonlinear phenomena associated evolution complex interfacial morphology. The Poisson equation for field and Navier–Stokes fluid flow are solved simultaneously along Cahn–Hilliard phase interface deformation morphology development. Numerical model validated against existing data results linear analysis. Extensive simulations carried out a wide range conditions....

Purpose/Relevance Fibrosis and hence capsule formation around the glaucoma implants are main reasons for implant failure. To address these issues, we designed a microfluidic meshwork tested its biocompatibility in rabbit eye model. The amount of fibrosis elicited by was compared to plate conventional drainage device. Methods Six eyes from 3 New Zealand albino rabbits were randomized receive either novel or Ahmed valve model PF7 (AGV PF7). flexible made negative photoresist SU-8 using...

This letter presents the design and implementation of a single-input multiple-independently configurable-output (SIMICO) dynamic voltage scaling supply (DVSS) for multiple-channel electrical stimulation applications. The proposed SIMICO DVSS mainly consists 3-stages charge pump (CP) 16 low-voltage (LV) compatible 5:1 power multiplexers (MUXs). CP is supplied by single VDD capable outputting four levels VDD, 2 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Simultaneous oxygenation and monitoring of glucose stimulus-secretion coupling factors in a single technique is critical for modeling pathophysiological states islet hypoxia, especially transplant environments. Standard hypoxic chamber techniques cannot modulate both stimulations at the same time nor provide real-time factors. To address these difficulties, we applied multilayered microfluidic to integrate aqueous gas phase modulations via diffusion membrane. This creates stimulation...

Neural interfaces for stable access to the spinal cord (SC) electrical activity can benefit patients with motor dysfunctions. Invasive high-density electrodes directly extract signals from SC neuronal populations that be used facilitation, adjustment, and reconstruction of actions. However, developing neural achieve high channel counts long-term intraspinal recording remains technically challenging. Here, a biocompatible hyperflexible electrode array (SHEA) an ultrathin structure minimizes...

Abstract System common mode rejection ratio (SCMRR) and interference (CMI) range are two critical design specifications for multiple‐channel neural recording front‐end circuit in a freely moving animal experiment environment. This letter presents amplifiers array consisting of 15 DC‐coupled inverter‐based channels, reference channel shared voltage averaging (VAC) with floating rail Common Mode Feedback (CMFB) to achieve high SCMRR large CMI range. Meanwhile, power consumption area optimized...

Environmental electromagnetic interference (EMI) has always been a major source for multiple-channel neural recording systems, and little theoretical work attempted to address it. In this paper, equivalent circuit models are proposed model both sources signals in such analysis performed generate the design guidelines probes subsequent towards higher common-mode (CMI) rejection performance while maintaining recorded action potential (AP) signal quality. vivo animal experiments with...

Although intracranial neural electrodes have significantly contributed to both fundamental research and clinical treatment of neurological diseases, their implantation requires invasive surgery open craniotomies, which can introduce brain damage disrupt normal functions. Recent emergence endovascular devices offers minimally approaches for recording stimulation. However, existing are unable resolve single-unit activity in large animal models or human patients, impeding a broader application...

Abstract Neurovascular coupling, the close spatial and temporal relationship between neural activity hemodynamics, is disrupted in pathological brain states. To understand altered neurovascular disorders, longitudinal, simultaneous mapping of hemodynamics critical yet challenging to achieve. Here, we employ a multimodal platform mouse model stroke realize long-term, spatially-resolved tracking intracortical cerebral blood flow same regions. We observe pronounced dissociation that occurs...

Across many areas, from neural tracking to database entity resolution, manual assessment of clusters by human experts presents a bottleneck in rapid development scalable and specialized clustering methods. To solve this problem we develop C-FAR, novel method for Fast, Automated Reproducible multiple hierarchical algorithms simultaneously. Our algorithm takes any number trees as input, then strategically queries pairs feedback, outputs an optimal among those nominated these trees. While it is...

Microfluidic devices offer novel techniques to address biological and biomedical issues. Standard microfluidic fabrication uses photolithography pattern channels on silicon wafers with high resolution. Even the relatively straightforward SU8 soft lithography in microfluidics require investing training photolithography, which is also time consuming due complicated thick resist procedures, including sensitive substrate pretreatment, coating, bake, expose, post-exposure developing steps....

A numerical phase field model is developed to investigate the Rayleigh-Taylor instability (RTI) subject a horizontal electric field. The entails simultaneous solution of equation and Navier-Stokes for fluid flow coupled with evolution fluid-fluid interface deformation morphology. in-house Fortran code was enable computing. Results show that, pure dielectric fluids, presence induces polarization charges produces Korteweg-Helmholtz force which acts suppress RTI. For poorly conducting liquids,...