A5078854319- Muscle Physiology and Disorders
- Sports Performance and Training
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Sports injuries and prevention
- Muscle metabolism and nutrition
- Telomeres, Telomerase, and Senescence
- Winter Sports Injuries and Performance
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Effects of Exercise
- Nutrition and Health in Aging
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Diet and metabolism studies
- RNA regulation and disease
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Lower Extremity Biomechanics and Pathologies
- Muscle activation and electromyography studies
- Mesenchymal stem cell research
- Genetics and Physical Performance
- Exercise and Physiological Responses
- Body Composition Measurement Techniques
ETH Zurich
2018-2024
University of Zurich
2018-2024
Board of the Swiss Federal Institutes of Technology
2020
Department of Medical Sciences
2019-2020
University Hospital of Zurich
2016
École Polytechnique Fédérale de Lausanne
2016
University of Bern
2012-2015
Leipzig University
2013
Endothelial cell (EC)-derived signals contribute to organ regeneration, but angiocrine metabolic communication is not described. We found that EC-specific loss of the glycolytic regulator pfkfb3 reduced ischemic hindlimb revascularization and impaired muscle regeneration. This was caused by ability macrophages adopt a proangiogenic proregenerative M2-like phenotype. Mechanistically, lactate secretion ECs lowered levels in muscle. Addition pfkfb3-deficient restored polarization an...
Endothelial cells (ECs) are highly glycolytic and generate the majority of their energy via breakdown glucose to lactate. At same time, a main role ECs is allow transport surrounding tissues. GLUT1 (glucose transporter isoform 1/Slc2a1) expressed in central nervous system (CNS) often implicated blood-brain barrier (BBB) dysfunction, but whether how controls EC metabolism function poorly understood.We evaluated endothelial during postnatal CNS development as well at adult BBB.Inhibition...
Ageing is associated with an attenuated hypertrophic response to resistance training and periods of interruptions. Hence, elderly would benefit from the 'muscle memory' effects on muscle strength mass during detraining retraining. As underlying mechanisms are not yet clear, this study investigated role myonuclei training, retraining by using PCM1 labelling in cross-sections six older men. Knee extension power were measured 30 men 10 controls before after 12 weeks similar length. In a subset,...
Abstract Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated via adipogenic differentiation fibro-adipogenic progenitors (FAPs). We used single-nuclei and single-cell RNA sequencing to characterize FAP heterogeneity in patients with fatty infiltration. identified an MME + subpopulation which, based on ex vivo characterization as well transplantation experiments, exhibits high potential. FAPs are characterized by low activity WNT, known control...
Abstract Background Satellite cells (SCs) are required for muscle repair following injury and involved in remodeling upon muscular contractions. Exercise stimulates SC accumulation myonuclear accretion. To what extent exercise training at different mechanical loads drive contribution to myonuclei however is unknown. Results By performing fate tracing experiments, we show that 8 weeks of voluntary wheel running increased myofibers mouse plantar flexor muscles a load-dependent, but fiber...
Exercise is a powerful driver of physiological angiogenesis during adulthood, but the mechanisms exercise-induced vascular expansion are poorly understood. We explored endothelial heterogeneity in skeletal muscle and identified two capillary cell (mEC) populations that characterized by differential expression ATF3/4. Spatial mapping showed ATF3/4+ mECs enriched red oxidative areas while ATF3/4low ECs lie adjacent to white glycolytic fibers. In vitro vivo experiments revealed more angiogenic...
Abstract Background Intramuscular fatty infiltration is generally associated with the accumulation of white adipocytes in skeletal muscle and unfavourable metabolic outcomes. It is, however, still unclear whether intramuscular could also acquire a brown‐like phenotype. Here, we detected expression brown adipocyte markers during an obesity‐resistant mouse strain extensively compared potential two different stem cell populations residing to differentiate into adipocytes. Methods Fatty was...
The purpose of this study was to analyse eventual kinematic and electromyographic changes during a maximal 200 m front crawl at race pace. 10 male international level swimmers performed test. Images were recorded by 2 above 4 under water cameras, signals (EMG) 7 upper lower limbs muscles analysed for 1 stroke cycle in each 50 lap. Capillary blood lactate concentrations collected before after the variables interest were: swimming speed, length, kick frequency, hand angular velocity, limb foot...
To describe the development of anthropometric and physical characteristics young Swiss alpine skiers between 2004 2011, to compare them age performance-level groups, identify age- sex-dependent reference values for tests performed.The Swiss-Ski Power Test includes measures coordination speed, strength, anaerobic capacity, endurance. The authors analyzed results 8176 performed by 1579 male 1109 female 2011. Subjects ranged regional national level performance were grouped according their...
The present study aimed to assess the relationship between rating of perceived exertion (RPE) and percentage peak oxygen uptake () during three head-out water-based aerobic exercises. In addition, RPE at second ventilatory threshold (VT2) was also compared among them. Twenty young women performed maximal tests for exercises stationary running (SR), frontal kick (FK) cross-country skiing (CCS). monitored values corresponding VT2 training zones 50–59%, 60–69%, 70–79%, 80–89% were determined....
To verify whether relative age effects (RAEs) occur among young male and female Swiss Alpine skiers of different groups performance levels. In addition, the efficacy normalizing in physical tests to height body mass attenuate RAEs eventually present was tested.The Ski Power Test consists anthropometric measures for coordination speed, endurance, strength has been used since 2004 evaluate 11- 19-y-old competitive skiers. The authors analyzed distribution 6996 performed by 1438 1031 between...
Abstract Background Hip osteoarthritis patients display higher levels of fatty infiltration (FI) in the gluteus minimus (GM) compared to other hip muscles. We investigated specific histological factors such as fiber type composition and collagen deposition, functional outcomes like muscle strength activation associated with FI these patients. Methods In twelve men (67 ± 6 y) undergoing total replacement (THR), knee (electromyography, EMG) were assessed bilaterally. Magnetic resonance imaging...
Abstract Satellite cells (SCs) are required for muscle repair following injury and involved in remodeling upon muscular contractions. Exercise stimulates SC accumulation myonuclear accretion. To what extent exercise training at different mechanical loads drive contribution to myonuclei however is unknown. By performing fate tracing experiments, we show that 8-weeks of voluntary wheel running increased mouse plantar flexor muscles a load-dependent but fiber type-independent manner. Increased...
Endothelial cell (EC) derived angiocrine signals contribute to organ regeneration, but metabolic communication is not described. We found that EC-specific loss of the glycolytic regulator pfkfb3 reduced ischemic hindlimb revascularization and impaired muscle regeneration. This was caused by ability macrophages adopt a proangiogenic proregenerative M2-like phenotype. Mechanistically, lactate secretion ECs lowered levels in muscle. Adding conditioned medium from pfkfb3-deficient rescued...
Aims: Free fatty acids (FFAs) are elevated in hyperlipidaemia which is a common pathology obese individuals and often associated with diabetes. Therefore, FFAs, whose secretion from adipose tissue increased obesity, have been suggested to link obesity type 2 Saturated such as palmitate, cause β-cell apoptosis could be mediated through persistent endoplasmic reticulum (ER)-stress also called Unfolded Protein Response (UPR).
Abstract Background Satellite cells (SCs) are required for muscle repair following injury and involved in remodeling upon muscular contractions. Exercise stimulates SC accumulation myonuclear accretion. To what extent exercise training at different mechanical loads drive contribution to myonuclei however is unknown. Results By performing fate tracing experiments, we show that 8-weeks of voluntary wheel running increased myofibers mouse plantar flexor muscles a load-dependent but fiber...
Abstract Background Satellite cells (SCs) are required for muscle repair following injury and involved in remodeling upon muscular contractions. Exercise stimulates SC accumulation myonuclear accretion. To what extent exercise training at different mechanical loads drive contribution to myonuclei however is unknown. Results By performing fate tracing experiments, we show that 8-weeks of voluntary wheel running increased myofibers mouse plantar flexor muscles a load-dependent but fiber...
Abstract Background Satellite cells (SCs) are required for muscle repair following injury and involved in remodeling upon muscular contractions. Exercise stimulates SC accumulation myonuclear accretion. To what extent exercise training at different mechanical loads drive contribution to myonuclei however is unknown. Results By performing fate tracing experiments, we show that 8-weeks of voluntary wheel running increased mouse plantar flexor muscles a load-dependent but fiber type-independent...
Summary/Abstract Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated via adipogenic differentiation fibro-adipogenic progenitors (FAPs). We used single-nuclei and single- cell RNA sequencing to characterize FAP heterogeneity in patients with fatty infiltration. identified an MME + subpopulation which, based on ex vivo characterization as well transplantation experiments, exhibits high potential. FAPs are characterized by low activity WNT, known...
Abstract While an exercise recovery method may be beneficial from a physiological point of view, it detrimental to subsequent anaerobic performance. To investigate the energetic responses water immersion at different temperatures during post-exercise and its consequences on A randomized controlled crossover experimental design was performed with 21 male trained cyclists triathletes. Participants were assigned randomly receive three passive strategies 10 min after Wingate Anaerobic Test...