A5051056487- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Immunotherapy and Immune Responses
- Retinal Development and Disorders
- Amyotrophic Lateral Sclerosis Research
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Neurogenetic and Muscular Disorders Research
- Prion Diseases and Protein Misfolding
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Memory and Neural Mechanisms
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Fluorescence Microscopy Techniques
- COVID-19 Prevention and Impact
- Cardiac Imaging and Diagnostics
- Ion Transport and Channel Regulation
International Association for Dental Research
2024
Universitas Malahayati
2021-2024
Indonesia Defense University
2024
Gatot Soebroto Army Hospital
2019-2023
Ministry of Health
2022
University of California, Irvine
2010-2020
Hasanuddin University
2016-2017
Surya University
2016
Zero to Three
2013
Niigata University
2006-2008
Adult-born dentate granule neurons contribute to memory encoding functions of the gyrus (DG) such as pattern separation. However, local circuit-mechanisms by which adult-born partake in this process are poorly understood. Computational, neuroanatomical and electrophysiological studies suggest that sparseness activation cell layer (GCL) is conducive for A sparse coding scheme thought facilitate distribution similar entorhinal inputs across GCL decorrelate overlapping representations minimize...
Key points Using functional mapping assays, we conducted a quantitative assessment of both excitatory and inhibitory synaptic laminar connections to neurons in layers 2/3–6 the mouse visual cortex (V1). Laminar‐specific wiring diagrams were constructed on basis circuit mapping. The present study reveals that connectivity is spatially balanced across neuronal networks V1. Abstract In mammalian neocortex, provide excitation columnar dimensions, which modulated further by neurons. However, our...
ABSTRACT The hippocampal CA2 subfield was initially identified by Lorente de Nó as an anatomically distinct region based on its cytoarchitectural features. Although there is enormous body of literature other subfields (CA1 and CA3), relatively little known about the physiological developmental properties CA2. Here we report identification in mouse immunostaining with a Purkinje cell protein 4 (PCP4) antibody, which effectively delineates CA3/CA2 CA2/CA1 borders agrees well previous...
Key points Melanin‐concentrating hormone (MCH) neurons express histamine‐3 receptor (H3R) mRNA but not histamine‐1 (H1R) or histamine‐2 (H2R) mRNA. Histamine inhibits MCH by activating postsynaptic H3R. This effect is mediated through G protein‐dependent inwardly rectifying potassium (GIRK) channels. may function to silence during wakefulness. Abstract (MCH)‐producing are known regulate a wide variety of physiological functions such as feeding, metabolism, anxiety and depression, reward....
Oligodendrocytes are the glial cells responsible for myelin formation. Myelination occurs during first postnatal weeks and, in rodents, is completed third week after birth. Myelin ensures fast conduction of nerve impulse; adult, proteins have an inhibitory role on axon growth and regeneration injury. During brain development, oligodendrocytes precursors originating multiple locations along antero-posterior axis actively proliferate migrate to colonize whole brain. Whether initial...
A characteristic of the developing mammalian visual system is a brief interval plasticity, termed “critical period,” when circuitry primary cortex most sensitive to perturbation experience. Depriving one eye vision (monocular deprivation [MD]) during critical period alters ocular dominance (OD) by shifting responsiveness neurons in favor nondeprived eye. disinhibitory microcircuit involving parvalbumin-expressing (PV) interneurons initiates this OD plasticity. The gene encoding neuronal...
The development of modern neuroscience tools is critical for deciphering brain circuit organization and function. An important aspect technical to enhance each technique's advantages compensate limitations. We developed a high-precision fast functional mapping technique in slices that incorporates the spatial precision activation can be achieved by laser-scanning photostimulation with rapid high-temporal resolution assessment evoked network activity voltage-sensitive dye imaging. Unlike...
Background Coronary calcification has been correlated with the presence and extent of coronary artery disease (CAD), so in present study associations between score (CACS) endothelial dysfunction, as well important inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, oxidized low-density lipoprotein (OxLDL), were studied asymptomatic individuals at intermediate risk for CAD. Methods Results The group comprised 177 subjects (103 males) aged 50.6±5.9 years. CACS was measured by...
Spontaneous network activity is believed to sculpt developing neural circuits. giant depolarizing potentials (GDPs) were first identified with single-cell recordings from rat CA3 pyramidal neurons, but here we identify and characterize a large-scale spontaneous term global activation (GNA) in the mouse hippocampal slices, which measured macroscopically by fast voltage-sensitive dye imaging. The initiation propagation of GNA largely GABA-independent dominated glutamatergic transmission via...
Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic thought underlie the aetiology neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that mouse visual cortex, strong does not develop if PV cells lack a single copy Pten. PTEN signalling appears drive assembly an experience-dependent manner suppressing expression EphB4; hemizygous for...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a world-wide pandemic. Internationally, because of availability, accessibility, and distribution issues, there is need for additional vaccines. This study aimed to: establish the feasibility personal dendritic cell vaccines to SARS-CoV-2 spike protein, safety single subcutaneous vaccine injection, determine antigen-specific immune response following vaccination. In Phase 1, 31 subjects were assigned one nine formulations...
The bed nucleus of the stria terminalis (BNST) is a key component extended amygdala and has been implicated in anxiety addiction. As individual neurons function within neural circuits, it important to understand local microcircuits larger network connections identified neuronal types how maladaptive changes BNST networks are induced by stress drug abuse. However, due limitations classic anatomical physiological methods, circuit organization synaptic inputs specific neuron not well...
Recent technical advances enable the regulation of neuronal circuit activity with high spatial and temporal resolution through genetic delivery molecular activation or inactivation systems.Among them, allatostatin receptor (AlstR)/ligand system has been developed for selective quickly reversible silencing mammalian neurons. However, targeted AlstR-mediated specific types, particularly diverse types inhibitory interneurons, remains to be established. In present study, we achieved Cre-directed...
Introduction: Slowly activating delayed‐rectifier potassium currents in the heart are produced by a complex protein with α and β subunits composed of voltage‐gated channel KQT‐like subfamily, member 1 (KCNQ1) Isk‐related family, (KCNE1), respectively. Mutations KCNQ1 underlie most common type hereditary long QT syndrome (LQTS). Like other channels, has six transmembrane domains highly conserved selectivity filter pore helix called “the signature sequence.” We aimed to investigate functional...
Inhibitory neurons are crucial to cortical function. They comprise about 20% of the entire neuronal population and can be further subdivided into diverse subtypes based on their immunochemical, morphological, physiological properties. Although previous research has revealed much intrinsic properties individual types inhibitory neurons, knowledge local circuit connections is still relatively limited. Given that each neuron's function shaped by its excitatory synaptic input within circuits, we...
Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease is a neurodegenerative and neuromuscular disorder characterized by progressive death of motor neurons & paralysis that culminates in death, usually within 3-5 years diagnosis from respiratory failure due to paralysis. Currently approved ALS therapies are not curative fail increase healthy lifespan.
Heavy metal toxicity has been conjectured as a possible risk factor for and player in amyotrophic lateral sclerosis (ALS) other neurodegenerative disorders. To test correlational relationship or linkage, we conducted retrospective study of 54 sALS 26 healthy volunteers who agreed to serve controls, all whom were seen at the Personalized Regenerative Medicine Clinic (San Clemente, California USA) between 2011 2016.