A5108831498- Lipid Membrane Structure and Behavior
- Lipid metabolism and biosynthesis
- HER2/EGFR in Cancer Research
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Advanced Breast Cancer Therapies
- Ion channel regulation and function
- Pregnancy and preeclampsia studies
- Cellular transport and secretion
- Neonatal Respiratory Health Research
- Axon Guidance and Neuronal Signaling
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Breast Cancer Treatment Studies
Utrecht University
2017-2025
Martin Luther University Halle-Wittenberg
2023
Luther University
2023
European Molecular Biology Laboratory
2022
European Molecular Biology Laboratory
2022
Highlights•Feline organoids can be cultured from fresh and frozen liver needle biopsy•A feline-specific culture medium allows organoid expansion up to 32 passages•When fed fatty acids, feline store more lipids than human organoids•Feline used model hepatic steatosisSummaryHepatic steatosis is a highly prevalent disease, yet research hampered by the lack of tractable cellular animal models. Steatosis also occurs in cats, where it cause severe failure. Previous studies demonstrate potential...
During development, different tissues acquire distinct lipotypes that are coupled to tissue function and homeostasis. In the brain, where complex membrane trafficking systems required for neural function, specific glycerophospholipids, sphingolipids, cholesterol highly abundant, defective lipid metabolism is associated with abnormal development neurodegenerative disease. Notably, production of requires appropriate programming underlying metabolic machinery during but when how this occurs...
The behavior of cells is governed by signals originating from their local environment, including mechanical forces that experience. Forces are transduced mechanosensitive proteins, which can impinge on signaling cascades also activated growth factor receptors upon ligand binding. We investigated the crosstalk between these and biochemical in regulation intracellular networks epithelial monolayers. Phosphoproteomic transcriptomic analyses monolayers subjected to strain revealed ERK as a...
Background: Diabetes mellitus (DM) is a common potentially life-threatening endocrine disorder in pets and humans. Since only symptomatic treatment available, more sustainable urgently needed. Objective: The aim of this study to establish functional differentiated canine pancreatic β-cells that release insulin upon glucose stimulus. Methods: Pancreatic tissue was obtained from surplus material healthy dogs (n = 4), euthanized for non-pancreatic related research. Ductal cells were isolated...
Abstract During development, different tissues acquire distinct lipotypes that are coupled to tissue function and homeostasis. In the brain, where complex membrane trafficking systems required for neural function, specific glycerophospholipids, sphingolipids, cholesterol highly abundant, defective lipid metabolism is associated with abnormal development neurodegenerative disease. Notably, production of tissue-specific requires appropriate programming underlying metabolic machinery, but when...
Abstract Introduction: HER2-positive breast cancer is considered aggressive, but due to the development of targeted drugs in past 20 years, a substantial improvement therapy results can be postulated. Proven evidence provided by data randomized clinical trials. The present study aimed at demonstrating over time using single-center real world data. Material and Methods: In our center, we prospectively built consecutive tumor base from 2000 2020 identified patients with early (n=396). cohort...