A5023871574- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Fungal Infections and Studies
- Fungal Biology and Applications
- Bee Products Chemical Analysis
- Antifungal resistance and susceptibility
- Indoor Air Quality and Microbial Exposure
- Yeasts and Rust Fungi Studies
- Skin Protection and Aging
- Reproductive tract infections research
- Spaceflight effects on biology
- Acne and Rosacea Treatments and Effects
- Fermentation and Sensory Analysis
- Wound Healing and Treatments
- Plant Pathogens and Fungal Diseases
- Plant Disease Resistance and Genetics
- Bacteriophages and microbial interactions
- Probiotics and Fermented Foods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Complementary and Alternative Medicine Studies
- Dermatological diseases and infestations
- Medicinal Plants and Neuroprotection
- Psoriasis: Treatment and Pathogenesis
- Herbal Medicine Research Studies
- Plant-Microbe Interactions and Immunity
Meiji Pharmaceutical University
2015-2024
Abstract The skin surface is colonized by a wide variety of fungi and bacteria. While many these organisms, including Malassezia , Candida Streptococcus Staphylococcus species, are associated with provocation and/or exacerbation psoriasis, detailed analysis the cutaneous fungal microbiome in psoriatic patients has yet to be performed. To identify disease‐specific microbiota on scale samples, r RNA gene sequences from 12 healthy controls were analyzed pyrosequencing. A total 317 806...
Seborrheic dermatitis (SD) is a chronic inflammatory dermatologic condition in which erythema and itching develop on areas of the body with sebaceous glands, such as scalp, face chest. The inflammation evoked directly by oleic acid, hydrolyzed from sebum lipases secreted skin microorganisms. Although fungal genus, Malassezia, thought to be causative agent SD, analysis bacterial microbiota samples patients SD necessary clarify any association Malassezia because comprises diverse genera. In...
The International Space Station (ISS) is a huge manned construct located approximately 400 km above the earth and inhabited by astronauts performing space experiments. Because station within closed microgravity environment, are subject to consistent stress. This study analyzed temporal changes in skin fungal microbiota of 10 using pyrosequencing quantitative PCR assay before, during, after their stay ISS. Lipophilic fungi, Malassezia predominated most samples regardless collection period,...
The fungus Trichosporon asahii is distributed widely in the environment and frequently isolated from clinical specimens. It can cause life-threatening disseminated infections, including breakthrough infection after administration of candin antifungal drugs. However, definitive route still unclear. In this study, 43 T. genotypes were detected 72 fecal samples healthy subjects. rRNA species determined using a culture-independent method. almost identical to those reported isolates. Therefore,...
The skin microbiome and sebum may be associated with inflammation-related diseases of the scalp. To assess pathogenesis progression androgenetic alopecia (AGA), we analyzed composition bacterial fungal microbiomes scalps 118 Japanese male individuals without AGA, then discussed their roles in AGA. Sebum triglyceride palmitic acid contents were higher AGA group than non-AGA group. Malassezia restricta, a lipophilic fungus that consumes acid, was abundant on patients Cutibacterium,...
The skin microbiome at lesion sites in patients with atopic dermatitis (AD) is characterized by dysbiosis. Although the administration of dupilumab, an IL-4Rα inhibitor, improves dysbiosis bacterial microbiome, information regarding fungal remains limited. This study administered dupilumab to 30 moderate-to-severe AD and analyzed changes both microbiomes over a 12-week period. Malassezia restricta M. globosa dominated whereas non-Malassezia yeast species increased abundance, leading greater...
The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. antifungal drug ketoconazole inhibits P. acnes activity. We previously showed that also growth of Thus, may serve as an alternative treatment for vulgaris, which important because number antibiotic-resistant strains has been increasing.
We previously reported the first isolation of Pseudozyma species from blood Thai patients. In this study, three additional new were isolated clinical specimens The showed relatively low sensitivity to azole antifungal agents. names proposed for these isolates are alboarmeniaca (DMST 17135(T) = JCM 12454(T ) CBS 9961(T)), crassa 17136(T 12455(T) 9959(T)) and siamensis 17137(T 12456(T) 9960(T)), where DMST is Department Medical Sciences Culture Collection, Japan Collection Microorganisms...
Four new yeast species belonging to the genus Apiotrichum and two Cutaneotrichosporon are described for strains isolated from guano samples bat-inhabited caves in Japan. In 2005, we reported these isolates as Trichosporon based on sequence analyses of D1/D2 domain large subunit (LSU) rRNA genes according available basidiomycetous classification criteria; however, date, they have not been officially published with descriptions. Their phylogenetic positions reanalysed comparison internal...
Euphorbia supina (ES) plant has been used as treatment for inflammatory conditions. The antibacterial effect and the anti-inflammatory mechanism of ES Propionibacterium (P.) acnes-induced inflammation in THP-1 cells acne animal model remain unclear. Therefore, objective present study was to determine activities against P. acnes, etiologic agent skin inflammation.The were tested with disc diffusion broth dilution methods. Cytotoxicity at different doses evaluated by MTT assay. stimulated...
The International Space Station (ISS) is located approximately 400 km above the Earth. Astronauts staying at ISS are under microgravity and thus unable to bathe or shower; instead, they wash their bodies using wet tissues. For astronauts, skin hygiene management important maintain quality of life during long-term stays on ISS. In Antarctica, members a Japanese geological investigation team negotiate way over land snowmobiles. During 3-month stay, subject "pseudo-space" environment similar...
Abstract Analysis of the skin mycobiome an astronaut during a 1-year stay on International Space Station (ISS) revealed increased relative abundance Malassezia restricta and level colonization, presence Cyberlindnera jadinii Candida boidinii, uncommon taxa. Similar observations were made in astronauts 6-month ISS (Med Mycol. 2016; 54: 232–239). Future plans for extended space travel should consider effect high levels colonization over long periods astronauts’ skin, abnormal proliferation...
The proportion of Staphylococcus aureus in the skin microbiome is associated with severity inflammation disease atopic dermatitis. epidermidis , a commensal bacterium, inhibits growth S . skin. Therefore, balance between and important for maintaining healthy In present study, we demonstrated that heat-treated culture supernatant Delftia acidovorans member microbiome, but not Comprehensive gene expression analysis by RNA sequencing revealed D increased genes related to glycolysis...
Malodorants in the human axilla are produced from biogenic precursors by axillary bacterial enzymes.In present study, we used pyrosequencing analysis to identify microbiota of 13 Japanese male subjects with cumin-like, spicy body odor (C type) , and 9 milky, skin-based (M .Anaerococcus, Corynebacterium, Staphylococcus predominated both C-and M-type subjects, followed Moraxella Peptoniphilus.These genera accounted for 96.2-99.9% total population, except one C-type subject.However, bacteria...
ABSTRACT Here, we report the draft genome sequence of Trichosporon domesticum JCM 9580, isolated from house a patient with summer-type hypersensitivity pneumonitis (SHP) in Japan. This genomic information will help elucidate mechanisms development SHP.
The aim of this study was to develop a method for the rapid detection Gardnerella vaginalis, which is proposed play key role in pathogenesis bacterial vaginosis. Specific loop-mediated isothermal amplification (LAMP) primers were designed and used detect target DNA within 45 min under conditions. Comparative screening indicated that LAMP assay superior PCR terms rapidity, equivalent sensitivity specificity. This can be G. vaginalis vaginal samples; limit 10 fg DNA.
Tacrolimus (FK506), an immunosuppressant and calcineurin inhibitor, has fungicidal effects. However, its effect is thought to be limited basidiomycetes, such as Cryptococcus Malassezia, not ascomycetes. FK506 had no on Candida albicans, C. auris, glabrata, guilliermondii, kefyr, krusei, tropicalis (>8 µg/mL); however, parapsilosis was susceptible it at low concentrations of 0.125–0.5 µg/mL. metapsilosis orthopsils, previously classified parapsilosis, are molecularly phylogenetically...
Background: Various types of microorganisms colonize the skin surface, and some such as bacterium Staphylococcus aureus fungus Malassezia, exacerbate symptoms atopic dermatitis. Malassezia-specific IgE antibodies are present in sera patients with dermatitis level thereof correlates severity condition. Malassezia has many genotypes. In study, we explored relationships among genotypes species colonizing dermatitis, clinical disease, specific antibody. Methods: Scale samples were obtained from...