A5037423193- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- X-ray Diffraction in Crystallography
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Cholinesterase and Neurodegenerative Diseases
- Nanoplatforms for cancer theranostics
- Heavy Metal Exposure and Toxicity
- Crystallization and Solubility Studies
- Enzyme Catalysis and Immobilization
- Nanoparticles: synthesis and applications
- Advanced Nanomaterials in Catalysis
- Magnetism in coordination complexes
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Luminescence Properties of Advanced Materials
- Adenosine and Purinergic Signaling
- Organic Chemistry Cycloaddition Reactions
- Laser Applications in Dentistry and Medicine
- Synthesis and Biological Evaluation
- Bacteriophages and microbial interactions
- Synthesis of β-Lactam Compounds
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Boron and Carbon Nanomaterials Research
CIC biomaGUNE
2018-2022
University of the Basque Country
2007-2009
University of Castilla-La Mancha
2007
Instituto de Química Física Blas Cabrera
2007
Abstract Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used theranostics as contrast agents magnetic resonance imaging (MRI), catalase‐mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance properties these nanomaterials simultaneously. Herein, a cost‐efficient microwave method is developed manufacture ultrasmall manganese...
The stereochemical outcomes observed in the thermal and microwave-assisted [3 + 2] cycloaddition between stabilized azomethine ylides nitrostyrenes have been analyzed using experimental computational approaches. It has that, absence of solvent, three stereoisomers are formed, both under classical heating conditions microwave irradiation. This result contrasts with that solution conditions. 4-nitropyrrolidines obtained this way can be aromatized further irradiation to yield mixtures pyrroles...
This study aimed to evaluate the effects of an intratesticular injection silver nanoparticles (AgNPs) on reproductive parameters and health rats, AgNPs biodistribution in order develop a nanotechnological contraceptive agent for male animals. Treated animals received 220 μL solution (0.46 µg-Ag/ml) each testicle were euthanized: seven, 14, 28, 56 days after injection. A significant decrease (p < 0.05) percentage motile sperm D7 (8.8%) was observed, comparing control (73.3%), D14 (86.0%), D28...
Lanthanide-doped upconverting nanoparticles (UCNPs) transform near infrared light (NIR) into higher-energy UV and visible by multiphotonic processes. Owing to such unique feature, UCNPs have found application in optical imaging been investigated for the NIR activation of prodrugs, including transition metal complexes interest photochemotherapy. Besides, also function as magnetic resonance (MRI) contrast agents positron emission tomography (PET) probes when labelled with radionuclides 18F. In...
An undecamer oligonucleotide probe based on a pair of deoxythymidines flanked by several modified nucleotides is specific and highly efficient biosensor for micrococcal nuclease (MNase), an endonuclease produced Staphylococcus aureus. Herein, the interaction mode cleavage process such probes are identified described first time. Also, we designed truncated pentamer as minimum-length substrates required biosensing. By means computational (virtual docking) experimental (ultra-performance liquid...
Kinetic control allows for the synthesis of mesoporous silica shells on top labile ZIF-8 cores without compromising MOF stability.
Abstract IKH12 is a novel histone deacetylase 6 selective inhibitor. A rapid and sensitive liquid chromatography tandem mass spectrometry method was developed validated for the quantification of in rat plasma tissue with kendine 91 as internal standard (IS). The samples were prepared by liquid–liquid extraction tert ‐butyl methyl ether. chromatographic separation accomplished using Zorbax Extend C 18 4.6 × 150 mm, 5 µm column, mobile phase consisting methanol 0.1% formic acid (75:25 v/v)....
Histone deacetylase 6 (HDAC6) is a protein modifier that an increasingly attractive pharmacological target. Interestingly, the observation HDAC6 knock-out mouse not lethal, in contrast to those undergoing complete loss of class I, II and III HDACs, suggests specific inhibitors may be better tolerated than pan-HDAC or drugs target other HDAC classes. In this regard, compound ACY-1215 (Rocilinostat), described selective inhibitor, clinical trials for treatment multiple myeloma. Taking into...
Abstract Histone deacetylase 6 (HDAC6) is a protein modifier that an increasingly attractive pharmacological target. Interestingly, the observation HDAC6 knock-out mouse not lethal, in contrast to those undergoing complete loss of class I, II and III HDACs, suggests specific inhibitors may be better tolerated than pan-HDAC or drugs target other HDAC classes. In this regard, compound ACY-1215 (Rocilinostat), described selective inhibitor, clinical trials for treatment multiple myeloma. Taking...
Surface engineering of metal-organic frameworks (MOFs) with a mesoporous silica coating can improve MOF mechanical properties and provide an easy way to decorate nanoparticles organic or biological molecules though silane chemistry electrostatic interactions, while retaining open access porosity. Silica would be highly beneficial for employing MOFs in wide range applications such as catalysis drug delivery. However, obtaining stable, controlled core-shell structure using seed is challenging...